Biflavone-manganese complex, as well as preparation method and application thereof
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A technology of manganese complexes and biflavones, which is applied in the field of bisflavone-manganese complexes and its preparation, can solve the problems that the synthesis and biological activity of bisflavone complexes have not been reported.
Inactive Publication Date: 2017-06-30
NANJING FORESTRY UNIV
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Problems solved by technology
[0006] So far, there is no report on the synthesis and biological activity of biflavone complexes
Method used
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Embodiment 1
[0039] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of ethanol, accurately weigh 17.9mg of 50% manganese nitrate solution (containing 0.05mmol of manganese nitrate), add it to 5mL of ethanol, add the manganese nitrate solution dropwise to the Ame solution , add ethanol-ammonia water (V / V, 3:1) solution dropwise to the reaction solution, adjust the pH to 6, keep it at 30°C for 4-5h, precipitate occurs, filter, wash with ethanol and water in turn, and recrystallize with DMSO , freeze-dried to obtain the Ame-Mn complex.
Embodiment 2
[0041] Accurately weigh 53.8 mg of Ame in a round bottom flask, dissolve it with 5 mL of 90% ethanol, accurately weigh 17.9 mg of 50% manganese nitrate solution (containing 0.05 mmol of manganese nitrate), add it to 5 mL of 90% ethanol, and drop the manganese nitrate solution Add it to the Ame solution, add ethanol-sodium ethylate solution dropwise to the reaction solution, adjust the pH to 5, keep it at 30°C for 4-5h, a precipitate occurs, filter, wash with ethanol and water in turn, recrystallize in DMSO, and freeze-dry to obtain Ame-Mn complexes.
Embodiment 3
[0043] Accurately weigh 53.8mg of Ame in a round bottom flask, dissolve it with 5mL of methanol, accurately weigh 17.9mg of 50% manganese nitrate solution (containing 0.05mmol of manganese nitrate), add it to 5mL of methanol, and add the manganese nitrate solution dropwise to Ame In the solution, add methanol-sodium methoxide solution dropwise to the reaction solution, adjust the pH to 7, keep at 40°C for 3-4h, precipitate occurs, filter, wash with methanol and water successively, recrystallize in DMSO, and freeze-dry to obtain Ame-Mn Complexes.
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Abstract
The invention discloses a biflavone-manganese complex, as well as a preparation method and an application of the biflavone-manganese complex. The amentoflavone-manganese complex is prepared by taking amentoflavone as a ligand and a manganese ion as a central ion for reaction, and a structure of the complex is characterized by an infrared spectrum, an ultraviolet-visible absorption spectrum and a high resolution mass spectrum. At the same time, the antitumor activity and the oxidation resistance activity of the amentoflavone-manganese complex are researched. An MTT (methyl thiazolyl tetrazolium) method shows that the amentoflavone-manganese complex has the better antitumor activity than amentoflavone; and both a pyrogallol autoxidation method and an ABTS (2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) method show that the amentoflavone-manganese complex has the better oxidation resistance activity than amentoflavone. Due to the formation of the biflavone-manganese complex, the antitumor activity and the oxidation resistance activity of amentoflavone are improved, and the biflavone-manganese complex is expected to be used for drug development.
Description
technical field [0001] The invention belongs to the technical fields of organic synthesis and medicine, and specifically relates to a biflavone-manganese complex and its preparation method and application. Background technique [0002] Biflavonoids are unique chemical components of gymnosperms, such as Ginkgo biloba and Selaginella, which have biological activities such as anti-oxidation, anti-inflammation, anti-virus, and anti-tumor. Among them, Amentoflavone (Amentoflavone, Ame) is a relatively common type of amentoflavone compounds, and its structural formula is as follows: [0003] [0004] Sun et al. found that amentoflavone increased the expression of anti-cancer genes by activating hPPARγ, thereby achieving the effect of inhibiting breast cancer cells and cervical cancer cells [Lee E., Shin S., Lee J. et al. Cytotoxic activities of amentoflavone against human Breast and cervical cancers are mediated by increasing of pten expression levels due to peroxisome prolife...
Claims
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