Meloxicam patch as well as preparation method and application thereof

A meloxicam and transdermal patch technology, applied in the field of medicine, can solve the problems of limiting meloxicam transdermal absorption, poor solubility, increasing meloxicam, etc., and achieve improvement of transdermal penetration, suppleness Good sex, long-lasting and stable effect

Active Publication Date: 2017-07-07
SHENYANG PHARMA UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the skin barrier is mainly composed of lipophilic stratum corneum and hydrophilic active epidermis, which indicates that only drugs with suitable lipophilicity can be absorbed by

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Add 7.5g of meloxicam into a small beaker, add 62.5g of ethanol and 31.25g of acetone, ultrasonically dissolve the drug, add 3.5g of laurocapram and 3.5g of N-methylpyrrolidone, stir to dissolve, add 300g of acrylate Stir until it is evenly mixed, let stand and degas, evenly coat on the anti-adhesive layer, volatilize the solvent, and then compound it with a backing material including PVC or non-woven fabric, die-cut into 1000 patches, that is have to.

Embodiment 2

[0027] Add 7.5g of meloxicam diethylamine into a small beaker, add 62.5g of ethanol and 31.25g of acetone, ultrasonically dissolve the drug, add 3.5g of laurocapram and 3.5g of N-methylpyrrolidone, stir to dissolve, add 300g Acrylic polymer, stir until mixed evenly, let it stand and degas, evenly coat on the anti-adhesive layer, evaporate the solvent, then compound it with a backing material including PVC or non-woven fabric, die cut into 1000 patches , that is.

Embodiment 3

[0029] Add 7.5g of meloxicam diethylamine into a small beaker, add 62.5g of ethanol and 31.25g of acetone, ultrasonically dissolve the drug, add 7.0g of oleic acid, stir to dissolve, add 300g of acrylate polymer, stir until well mixed , stand still and degassed, evenly coated on the anti-adhesive layer, volatilize the solvent, then compound with backing material including PVC or non-woven fabric, die-cut into 1000 patches, that is.

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PUM

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Abstract

The invention provides a meloxicam patch as well as a preparation method and application thereof. The meloxicam patch comprises a back lining layer, a medicine storage layer and an anti-sticking layer, wherein medicine storage layer is prepared from an active component-meloxicam or pharmaceutically acceptable salts thereof, pressure-sensitive adhesive and a drug transdermal absorption accelerant, wherein the dosages of the meloxicam or the pharmaceutically acceptable salts thereof and the drug transdermal absorption accelerant respectively account for 0.5-60% and 0.1-50% of the solid component weight content of the medicine storage layer. The preparation method of the meloxicam patch comprises the steps of dissolving the meloxicam or the pharmaceutically acceptable salts thereof into a solvent, sequentially adding all pharmaceutic accessories into the obtained solution, stirring and evenly mixing; standing and degassing, coating, volatilizing the solvent, compounding the back lining layer, and cutting the product into a patch with suitable size according to the dosage requirement. The meloxicam patch is high in adhesiveness and good in flexibility, not only can avoid stimulation, caused by orally taking a medicine, for the gastrointestinal tract, but also can improve the transdermal permeation of the medicine, is lasting and stable in curative effect, and can be interrupted at any time.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a meloxicam patch with excellent stability and wide concentration range and a preparation method thereof. Background technique [0002] As the first cyclooxygenase-2 (COX-2) inhibitor on the market, meloxicam has a strong analgesic and anti-inflammatory effect in a large number of clinical trials, and it is effective for osteoarthritis and rheumatoid joints. The treatment effect of patients with inflammation and sciatica is comparable to or even better than that of current NSAIDs, and the daily dose is much lower than that of piroxicam, diclofenac, indomethacin and naproxen, and the incidence of gastrointestinal side effects very low. Since the product was launched in 1996, its dosage form has developed very fast. In addition to the commonly used 7.5mg / 15mg tablets and capsules, 15mg suppositories and 15mg injections are also widely used. With the continuous development of cycl...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K31/5415A61P29/00A61P19/02
CPCA61K9/7023A61K31/5415
Inventor 孙英华徐星星陶明月
Owner SHENYANG PHARMA UNIVERSITY
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