Preparation method and applications of urchin-shaped Ni-Zn metal organic skeleton hollow sphere nano material

Abstract

The invention discloses a preparation method and applications of an urchin-shaped Ni-Zn metal organic skeleton hollow sphere nano material, and belongs to the technical field of enzyme-free glucose sensor preparation. According to the preparation method, an ethanediol mixed solution of a bivalent nickel salt and a bivalent zinc salt is mixed with a DMF solution of terephthalic acid, hydrothermal reaction is carried out at 150 to 200 DEG C, and an obtained reaction precipitate is collected; the reaction precipitate is washed with DMF and ethanol, and is dried so as to obtain a finished product. The urchin-shaped Ni-Zn metal organic skeleton hollow sphere nano material is obtained via simple hydrothermal reaction; the raw materials are nontoxic, are friendly to the environment, and are cheap; the preparation method is simple, is convenient to control, and is suitable for continuous large-scale production; under ultrasonic conditions, the urchin-shaped Ni-Zn metal organic skeleton hollow sphere nano material is dissolved in a perfluorosulfonic acid type polymer solution, and then a glassy carbon electrode is modified with an obtained mixed solution so as to obtain an enzyme-free glucose sensor rapid in response, and high in sensitivity and stability; and application prospect in the field of blood sugar detection is promising.

Description

technical field [0001] The invention belongs to the technical field of preparation of an enzyme-free glucose sensor. Background technique [0002] Glucose exists widely in nature and is a kind of monosaccharide. The change of glucose content in the human body is closely related to human health. Diabetes is a worldwide chronic disease characterized by hyperglycemia. Therefore, the detection of blood glucose level has increasingly become an important way for timely diagnosis and strict management of diabetes. At present, the most commonly used method to check the level of blood sugar in the human body is to draw blood for measurement. If this method is not handled properly, it may cause infection to the patient. Some current sensors are difficult to detect low-concentration glucose. And the sensitivity is also poor. At present, there are many restrictive conditions for enzyme-containing glucose sensors. The activity of glucose oxidase is affected by many aspects. The accur...

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Problems solved by technology

[0003] At present, the electrode materials of enzyme-free electrochemical glucose sensors have the defect that the process of detecting glucose is easily affected by other interfering substances (such as chloride ions, uric acid), thus affecting the accuracy of the detection results

Moreover, the linear range of the existing sensors for enzyme-free glucose detection is relatively narrow, which is far lower than the normal blood sugar concentration (fasting) range (4.4-6.6 mM) of the human body. The smaller linear range makes its application in diabetes detection subject to very restrictive

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