Composite starch styptic powder

A technology of compound starch and hemostatic powder, applied in the field of medical supplies, can solve the problems of limited utilization rate, slow water absorption of starch microspheres, and low water absorption rate, and achieve the effect of accelerating activation and shortening coagulation time.

Inactive Publication Date: 2017-07-18
JIANGSU HUANENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the hemostatic effect is excellent, but first, because its cross-linking agent is epichlorohydrin, it will release potential toxic substances when it degrades; second, the water absorption rate is not very high, so the hemostatic effect needs to be improved; third, the price is too high. Too high, limiting its usage
Document "Using Potato Starch to Prepare Hemostatic Material Method" (Health and Medical Equipment, March 2014, Volume 35, No. 3, 23-25), using potato starch as raw material, through the methods of gelatinization, enzymatic hydrolysis and crosslinking Potato starch hemostatic powder is prepared, the process is more complicated, and the prepared starch microspheres absorb water slowly, and the hemostatic effect of using a single potato starch is not good

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of the composite starch hemostatic powder of this embodiment is as follows:

[0026] ① Take 10g of starch and add 200ml of purified water and stir until gelatinization, then add 10g of sodium carboxymethyl cellulose, and use NaOH to adjust the pH to 7.

[0027] ②Add 750ml of liquid paraffin to the reaction kettle, and after the temperature is raised to 75°C, add 20ml of a mixture of Span 80 and 30ml Tween 80.

[0028] ③Mix ① into ② and react for 8h, then take the material.

[0029] ④Add absolute ethanol to separate materials, pour off the upper oil phase, repeat washing and suction filtration with absolute ethanol 3 times, dry in an oven, grind, sieve, pack, and sterilize.

Embodiment 2

[0031] The preparation method of the composite starch hemostatic powder of this embodiment is as follows:

[0032] ① Take 10g of starch and add 800ml of purified water and stir until gelatinization, then add 0.1g of sodium alginate, and adjust the pH to 9 with NaOH.

[0033] ② Put 150ml of vegetable oil into the reaction kettle, and when the temperature reaches 65°C, add 2ml of Span 80 and 3ml of Tween 80 mixture.

[0034] ③ Mix ① into ② and react for 16 hours, and then take the material.

[0035] ④Add absolute ethanol to separate materials, pour off the upper oil phase, repeat washing and suction filtration with absolute ethanol 3 times, dry in an oven, grind, sieve, pack, and sterilize.

Embodiment 3

[0037] The preparation method of the composite starch hemostatic powder of this embodiment is as follows:

[0038] ① Take 10g of starch and add 500ml of purified water and stir until gelatinization, then add 5g of sodium carboxymethyl cellulose, and use NaOH to adjust the pH to 11.

[0039] ②Put 500ml of vegetable oil into the reaction kettle, and when it is heated to 70°C, add 10ml of a mixture of Span 80 and 10ml of Tween 80.

[0040] ③Mix ① into ② and react for 24h, then take the material.

[0041] ④Add absolute ethanol and ethyl acetate to separate the materials, pour off the upper oil phase, repeat washing and suction filtration with absolute ethanol 3 times, dry in an oven, grind, sieve, pack, and sterilize.

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Abstract

The invention provides composite starch styptic powder which is made of one of purified water, sweet potato starch, sodium alginate and sodium carboxymethylcellulose, an emulsifier and a dispersing agent as raw materials in an emulsification manner, wherein the emulsifier is selected from span and tween; and the dispersing agent is selected from paraffin or plant oil. The composite starch styptic powder provided by the invention has the technical effects that the powder is extracted from plant starch, when polysaccharide styptic granules are placed on bleeding wounds, moisture in blood can be absorbed by molecules of the granules, visible components of the blood are accumulated on the surfaces of the granules, then a gel mixture is formed, and the effect of stopping bleeding in time is achieved; meanwhile, activation of intrinsic coagulation factors can be accelerated, the intrinsic coagulation time can be shortened, partial sludged blood can be formed, and the stypticity action can be completed within tens of seconds.

Description

Technical field [0001] The invention relates to a compound starch hemostatic powder, which belongs to the technical field of medical supplies. Background technique [0002] Hemostasis plays a particularly important role in surgery. A series of postoperative complications due to excessive bleeding not only increase the difficulty of the doctor’s work, but also make the patient take a lot of risks during or after surgery . This has led to the emergence of a series of local hemostatic materials. At present, the hemostatic materials on the market mainly include gelatin, collagen, oxidized cellulose, regenerated oxidized cellulose, and starch microspheres. Among them, gelatin and collagen products are prepared from animal-derived raw materials, which have long absorption time and high tissue inflammatory response rate; oxidized cellulose and regenerated oxidized cellulose are made of plant cellulose, although the tissue response is low , No complications were found, but there is a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/08
CPCA61L24/0042A61L24/0036A61L24/08A61L2400/04C08L5/04C08L3/02C08L1/286
Inventor 蔡迪霞孙萍钱德余耿家敏钱靖祝俊
Owner JIANGSU HUANENG PHARMA
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