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Multilayer nanofiber micro-caliber vascular tissue engineering scaffold material and preparation method thereof

A technology of nanofibers and vascular tissues, applied in fiber processing, cellulose/protein conjugated artificial filaments, pharmaceutical formulations, etc., can solve problems affecting the mechanical properties of stents, achieve good biocompatibility, not prone to thrombus, and easy to operate convenient effect

Active Publication Date: 2020-06-26
ZHONGYUAN ENGINEERING COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved in the present invention is that the existing electrospinning technology will affect the mechanical properties of the scaffold for the construction of micro-diameter tissue engineering blood vessels with a diameter of less than 1.5 mm, and a multi-layer nanofiber micro-diameter tissue engineering blood vessel scaffold material and its preparation are provided method

Method used

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  • Multilayer nanofiber micro-caliber vascular tissue engineering scaffold material and preparation method thereof
  • Multilayer nanofiber micro-caliber vascular tissue engineering scaffold material and preparation method thereof
  • Multilayer nanofiber micro-caliber vascular tissue engineering scaffold material and preparation method thereof

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Effect test

Embodiment 1

[0024] A preparation method of multi-layer nanofiber micro-diameter blood vessel tissue engineering scaffold material, the steps are as follows:

[0025] (1) Dissolve L-polylactic acid polycaprolactone copolymer (PLCL) and silk fibroin (SF) in hexafluoroisopropanol (HFIP) at a mass ratio of 19:1, using polyethylene glycol 400 as an emulsifier , emulsified to obtain a solution containing heparin and endothelial cell growth factor (VEGF) as the inner layer spinning solution A of the tissue engineering stent material; PLGA and silk fibroin (SF) were placed in hexafluoroisopropanol at a mass ratio of 19:1 (HFIP), after being dissolved evenly, add 0.1% platelet-derived factor (PDGF) and stir evenly to obtain the middle layer spinning solution B of the stent material; dissolve polycaprolactone (PCL) in HFIP to obtain a mass concentration of 8% The spinning solution C of the outer layer of the stent;

[0026] (2) Build the electrospinning device according to the figure 1 (1 winding ...

Embodiment 2

[0032] A preparation method of multi-layer nanofiber micro-diameter blood vessel tissue engineering scaffold material, the steps are as follows:

[0033] (1) Dissolve the poly(L-lactic acid-polycaprolactone copolymer (PLCL) and silk fibroin (SF) in step (1) in hexafluoroisopropanol (HFIP) at a mass ratio of 10:1, Diol 400 is used as an emulsifier, emulsified to obtain a solution containing heparin and endothelial cell growth factor (VEGF) as the inner layer spinning solution A of the tissue engineering stent material; PLGA and silk fibroin (SF) are placed in a mass ratio of 10:1 In hexafluoroisopropanol (HFIP), after being dissolved evenly, add a certain amount (0.3%) of platelet-derived factor (PDGF) and stir evenly to obtain the middle layer spinning solution B of the stent material; polycaprolactone (PCL) Dissolved in HFIP to obtain a spinning solution C with a mass concentration of 7% of the outer layer of the stent;

[0034] (2) Build an electrospinning device, use nylon f...

Embodiment 3

[0039] A preparation method of multi-layer nanofiber micro-diameter blood vessel tissue engineering scaffold material, the steps are as follows:

[0040] (1) Dissolve the poly(L-lactic acid-polycaprolactone copolymer (PLCL) and silk fibroin (SF) in step (1) in hexafluoroisopropanol (HFIP) at a mass ratio of 1:1, and dissolve them in polyethylene Diol 400 is used as an emulsifier, emulsified to obtain a solution containing heparin and endothelial cell growth factor (VEGF) as the inner layer spinning solution A of the tissue engineering stent material; PLGA and silk fibroin (SF) are placed in a mass ratio of 1:1 In hexafluoroisopropanol (HFIP), after being dissolved evenly, add a certain amount (0.5%) of platelet-derived factor (PDGF) and stir evenly to obtain the middle layer spinning solution B of the stent material; polycaprolactone (PCL) Dissolved in HFIP to obtain a spinning solution C with a mass concentration of 10% of the outer layer of the stent;

[0041] (2) Build an ...

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Abstract

The invention discloses a multi-layer nanofiber micro aperture vascular tissue engineering support material which is a covering yarn which is prepared on the basis of a nanofiber covering yarning technique and is of a three-layer nanofiber structure, and the multi-layer nanofiber micro aperture vascular tissue engineering support material can be prepared after core yarns are pulled out. The multi-layer nanofiber micro aperture vascular tissue engineering support material disclosed by the invention is simple in preparation method, low in cost and good in biocompatibility induction property, and can be used as a remediation and replacing material of vascular tissue.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a multi-layer nanofiber micro-diameter vascular tissue engineering scaffold material and a preparation method thereof, which are applied to blood vessel repair or blood vessel replacement materials. Background technique [0002] In modern society, with the change of people's dietary structure, the acceleration of life rhythm and the increase of work pressure, the incidence of cardiovascular disease is increasing year by year. According to the statistics of the World Health Organization, at the beginning of the 21st century, 17.1 million people died of cardiovascular diseases in the world every year, accounting for about 1 / 3 of the total deaths in the world. It is estimated that by 2030, 23.6 million people will die of cardiovascular diseases every year. Obviously, The prevention and treatment of cardiovascular diseases occupy an important position in medicine. Cardiov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/48A61L27/50D01F8/14D01F8/02D01D5/00
CPCA61L27/18A61L27/227A61L27/507A61L2400/12D01D5/003D01D5/0061D01F8/02D01F8/14
Inventor 何建新邵伟力王利丹王倩周玉嫚齐琨佑晓露南楠孙显强胡宝继卢凯高艳菲崔世忠
Owner ZHONGYUAN ENGINEERING COLLEGE
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