A kind of total flavonoid aglycone extract of Sichuan Shegan and its preparation method and application
A technology for total flavonoid aglycone and shegan aglycone, which is applied in the field of total flavonoid aglycone extract from Chuanshegan, can solve the problems of complex process, low product yield, difficult product drying, etc., and achieves simple preparation process, high purity and effect excellent effect
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Embodiment 1
[0028] Embodiment 1 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention
[0029] Take 10kg of Chuanshegan crude drug crude powder, add 10L of 5% HCl aqueous solution, mix well, seal, place at room temperature for 15 days, place in a 100L enamel reaction kettle, heat and reflux with 40L of 95% ethanol to extract twice, 1 hour each time, The extracts were combined, concentrated under reduced pressure to 10 L, left overnight, precipitated, filtered, and washed with water until neutral. The precipitate was heated to reflux and dissolved in 5L of 95% ethanol, washed into 5L of boiling water, left overnight, precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brownish-yellow dry and loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 6 %, Shegan aglycon content 20.56%, total flavonoid aglycon content 51.42%.
Embodiment 2
[0030] Embodiment 2 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention
[0031] Take 10kg of Chuanshegan crude drug crude powder, add 10L of 5% HCl aqueous solution, mix well, seal, place at 45°C for 5 days, put it in a 100L enamel reaction kettle, heat and reflux with 40L of 95% ethanol to extract twice, each time After 1 hour, the extracts were combined, concentrated under reduced pressure to 10 L, left overnight, a precipitate precipitated, filtered, and washed with water until neutral. The precipitate was dissolved in 5L of 95% ethanol under reflux, washed into 5L of boiling water, left overnight, precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brownish-yellow dry and loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 7 %, Shegan aglycon content 21.25%, total flavonoid aglycon content 57.91%.
Embodiment 3
[0032] Embodiment 3 The preparation of the total flavonoid aglycone extract of Chuanshegan of the present invention
[0033] Take 10kg of Chuanshegan raw medicinal powder, put it in a 100L enamel reaction kettle, add 40L of 5% HCl aqueous solution, heat and reflux for 10 hours, filter, and extract the dregs twice with 40L of 95% ethanol under reflux, 1 hour each time, The extracts were combined, concentrated under reduced pressure to 10 L, left overnight, precipitated, filtered, and washed with water until neutral. The precipitate was heated to reflux and dissolved in 5L of 95% ethanol, washed into 5L of boiling water, left overnight, precipitated, filtered, and dried under reduced pressure at 60°C to obtain a brown-yellow dry loose powder, namely the total flavonoid aglycone extract of Chuanshegan, with a yield of 7.5 %, Shegan aglycon content 22.12%, total flavonoid aglycon content 53.38%.
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