A kind of medicine for treating insulin resistance, preparation method and application
A technology of insulin resistance and preparation, which is applied in the fields of application, drug combination, and pharmaceutical formula, and can solve the problems that have not yet been reported on the research reports on the prevention and treatment of insulin resistance by Gingeria japonica
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Embodiment 1
[0024] Example 1: Preparation of Gingeria japonica extract
[0025] Take 1Kg of Zingiber officinalis medicinal material, dry it in an oven at 60°C for 24 hours, and then pulverize it. Add 1000ml of ethanol aqueous solution with a volume fraction of 70% to the pulverized medicinal materials, soak at room temperature for 2 hours, heat in a water bath to reflux, and extract by reflux for 2 hours each time, and reflux extraction for 3 times in total; collect the ethanol extract and recover the ethanol until it has no alcohol smell. Dry the crude extract, dissolve the crude extract in water to obtain an aqueous solution, extract with petroleum ether to obtain a petroleum ether layer and a water layer; extract with ethyl acetate to obtain an ethyl acetate layer and a water layer; add n-butanol for extraction, The n-butanol extract is obtained, and the n-butanol extract is subjected to solvent recovery and dried to obtain the extract of the present invention.
[0026] The crude extr...
Embodiment 2
[0027] Example 2: Experimental study on the hypoglycemic effect of the extract of Gingeria officinalis
[0028] 50 9-week-old male ob / ob mice were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., under normal feeding conditions (standard mouse feed, room temperature 23°C, humidity 70%, 12h / 12h day / night) After acclimating to the environment for 1 week, fasting for 6 hours and measuring tail vein blood glucose levels, 30 animals with fasting blood glucose above 10mmol / L were included in this study. 30 male mice were randomly divided into 5 groups, 6 animals in each group: model group, metformin group and extract high (200mg / Kg), medium (100mg / Kg) and low (50mg / Kg) dose groups, another Six wild-type C57BL / 6J mice served as the normal control group. The normal control group and the model group were given distilled water, the positive drug group was given rosiglitazone (10 mg / kg), and the extract high, middle and low dose groups were given correspond...
Embodiment 3
[0033]Example 3 The preparation example of the Gingeria japonica extract powder in the present invention
[0034] The prepared Zingiber officinalis extract was ground into fine powder and sieved, and 1 part of the sifted fine powder of the Chinese medicine extract was taken, 3.5 parts of starch and 6.5 parts of lactose were added and mixed evenly by the equal amount incremental mixing method, The powder is prepared in divided doses according to the volumetric method.
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