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Double-layer collagen dermal scaffold and preparation method thereof

A technology of collagen and dermis, applied in medical science, prostheses, etc., can solve problems such as low extensibility, easy infection, and small pore size of the collagen layer, so as to achieve good clinical application prospects, improve healing quality, and reduce scar formation Effect

Active Publication Date: 2017-08-18
天新福(北京)医疗器材股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But its disadvantage is that the pore size of the collagen layer is relatively small, which is not conducive to the vascularization process in the early stage of healing. At the same time, when removing the silicone layer, the scalpel is assisted, which may cause secondary damage to the wound.
[0005] At the same time, there are some similar products that use a biocompatible adhesive to complete the compounding of the silica gel layer and the collagen layer, but the final product is often not very extensible and has poor compliance. When the active part is used, there will be a cavity, which is easy to cause infection

Method used

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  • Double-layer collagen dermal scaffold and preparation method thereof
  • Double-layer collagen dermal scaffold and preparation method thereof
  • Double-layer collagen dermal scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A double-layer collagen dermis support is composed of a collagen layer and a silica gel layer; the collagen layer is a collagen sponge layer, and the silica gel layer is a silica gel mixture layer or a pretreated silica gel mixture layer.

[0030] The above-mentioned double-layer collagen dermis support, the preparation method of the silica gel mixture layer: take 70-100wt% silica gel and 0-30wt% octamethyltrisiloxane and mix uniformly to obtain silica gel mixture a, press 0.01mL-0.1mL / 10 ratio Weigh the silica gel mixture a to prepare the silica gel mixture layer, and control the film thickness of the silica gel mixture a to be between 0.05 mm and 0.5 mm.

[0031] The above-mentioned double-layer collagen dermis support, the preparation method of the pretreated silica gel mixture layer: take 70-100wt% silica gel and 0-30wt% volatile silicone oil and mix uniformly to obtain silica gel mixture b, press 0.01mL-0.1mL / Take the silica gel mixture b at a ratio of 10 and pla...

Embodiment 2

[0035] Take 70-100% silica gel and 0-30% octamethyltrisiloxane, mix well, take the silica gel mixture at the ratio of 0.01mL-0.1mL / 10 and place it on the surface of the collagen sponge, scrape the silica gel with a spatula, the thickness 0.05-0.5 mm, cured at a temperature of 50-110°C and a relative humidity of 50-90RH% for 0.5-7 hours.

Embodiment 3

[0037] Take 70-100% silica gel and 0-30% volatile silicone oil, mix well, take the silica gel mixture at the ratio of 0.01mL-0.1mL / 10 and place it on the surface of the protective basement membrane, and use a scraper to control the thickness of the silica gel film at 0.05-0.5mm, After curing at 20-50°C and 20-40RH% for 1-10 minutes, attach the collagen layer on the surface of the silica gel film, and then secondly cure at a temperature of 50-110°C and a relative humidity of 50-90RH% for 0.5-10 minutes. 7h.

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Abstract

The invention relates to a double-layer collagen dermal scaffold and a preparation method thereof; the double-layer collagen dermal scaffold comprises a collagen layer and a silicone layer; the collagen layer is a collagen sponge layer, and the silicone layer is a silicone mixture layer or a pretreated silicone mixture layer; the collagen layer induces cell migration and promotes proliferation and differentiation so as to accelerate the recovery of an affected part; along with the degrading of material, regenerated tissues integrated to tissues around are finally formed; the silicone layer is semipermeable membrane, which is capable of controlling water loss of the affected part, protecting the wound and avoiding infection, has good mechanical strength and helps suture and fix the double-layer collagen dermal scaffold; by combining collagen and the silicone layer, it is possible to accelerate the growth of granulation tissues; by controlling collagen concentration and pH value to control the degrading rate of the collagen layer, the silicone layer can be removed smoothly after the granulation tissue phase; by transplanting auto-epidermis, healing cycle can be shortened, healing quality can be improved, and scars are decreased.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering biomaterials, and in particular relates to a double-layer collagen dermis support and a preparation method thereof. Background technique [0002] Skin is an important tissue organ that covers and protects the body surface. Defects and abnormalities of the skin are often caused by inflammation, ulcers, trauma, burns, postoperative tumors, and congenital deformities. For exposed skin wounds, gauze is traditionally used the most. Gauze is mostly processed from cotton, burlap and linen, and is an inert material that does not directly promote wound healing. With the in-depth research on wound healing, it is realized that not only the wound surface must be covered, but also the wound must be helped to heal. Biomaterials composed of extracellular matrix are one of the ideal products, and their main components include collagen, non-collagenous glycoproteins, elastic fibers, glycosaminoglycan...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L27/58A61L27/60
CPCA61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L27/58A61L27/60C08L5/08C08L83/04
Inventor 康承桂张伊骁
Owner 天新福(北京)医疗器材股份有限公司
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