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Application and preparation method of Tibetan capillaris pharmaceutical composition

A composition and drug technology, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of inability to guarantee the dissolution rate of drugs, large void ratio between drugs and carriers, and hydrophobic materials. The ratio is large and other problems, to achieve the effect of improving bioavailability, shortening the production cycle, and improving the dissolution rate

Active Publication Date: 2017-08-29
西安远大德天药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Chinese invention patent CN 102499890 B discloses a method for preparing a drug hot-melt extrusion moisture-proof preparation. In this invention, the drug is mixed with the carrier and then extruded in a single time, which may cause the drug to not be fully mixed with the carrier material, and the drug and the carrier The interspace ratio is still relatively large, and the proportion of hydrophobic materials used in this invention is relatively large, and the proportion of hydrophilic materials is relatively small, so that the drug dissolution rate cannot be guaranteed to be significantly improved.

Method used

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  • Application and preparation method of Tibetan capillaris pharmaceutical composition
  • Application and preparation method of Tibetan capillaris pharmaceutical composition
  • Application and preparation method of Tibetan capillaris pharmaceutical composition

Examples

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Comparison scheme
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Embodiment 1～ Embodiment 30

[0032] Embodiment 1~Example 30 are used to describe the preparation method of Tibetan Yinchen pharmaceutical composition granules:

Embodiment 1

[0034] In this example, the preparation method of the medicinal composition granules of Capillary cypress, the medicinal composition of Capillary cypress consists of the following components by weight percentage: 10% dry powder of extract of Capillary cypress, 45% of hydrophilic polymer material, and 45% of hydrophobic macromolecule material. %, the method includes the following steps:

[0035] Step 1, after pulverizing 10g of the extract dry powder of Capillary cypress, pass through a 100-mesh sieve to obtain the undersieve, then add 45g of hydrophilic polymer material to the undersieve, and mix uniformly to obtain the mixture; the hydrophilic The polymer material is copovidone (Kollidon VA64);

[0036]Step 2. Place the mixture obtained in step 1 in the feeding hopper of the hot-melt extruder, and set the temperatures of the seven heating zones of the hot-melt extruder to be 75°C in the first zone, 120°C in the second zone, and 120°C in the third zone. Zone 140°C, Zone 4 140...

Embodiment 2

[0040] This embodiment is the same as Example 1, except that the hydrophilic macromolecular material is polyethylene caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, polyvinylpyrrolidone, polyethylene glycol Or polyacrylonitrile, or be at least two in copovidone, polyvinylcaprolactam-polyvinyl acetate-polyethylene glycol graft copolymer, polyvinylpyrrolidone, polyethylene glycol and polyacrylonitrile; The polymer material is acrylic resin No. IV, glyceryl behenate, glyceryl palmitate or glyceryl monostearate, or polyacrylic resin, acrylic resin No. IV, glyceryl behenate, stearic acid At least two of glyceryl palmitate and glyceryl monostearate.

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Abstract

The invention discloses a preparation method of a Tibetan capillaris pharmaceutical composition. The method includes: step one, mixing Tibetan capillaris extract dry powder with a hydrophilic high polymer material; step two, performing hot-melt extrusion to obtain extrudate; step three, grinding, filtering, and adding a hydrophobic high polymer material to form a mixture; step four, adding the mixture into a hot-melt extrusion machine to obtain extrudate, cooling the extrudate to the room temperature, and filtering to obtain granules of the Tibetan capillaris pharmaceutical composition. The invention further discloses application of the Tibetan capillaris pharmaceutical composition. By the preparation process, organic solvent consumption is avoided, the medicine dissolution rate can be effectively increased, and bioavailability is improved; Tibetan capillaris solid dispersion granules are coated with the molten hydrophobic material, interaction between the medicine and moisture in air is well prevented, and accordingly a damp insulation effect is achieved; the prepared granules can be directly filled into capsules or subjected to tabletting with appropriate auxiliary materials to obtain tablets.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a preparation method and application of a Tibetan fungus medicinal composition. Background technique [0002] Tibetan Yinchen is a treasure of Chinese national medicine, one of the eight treasures of Tibetan medicine in the Qinghai-Tibet Plateau, and the most distinctive common drug in Tibetan medicine for treating fever, liver and gallbladder diseases and blood diseases. It is clinically used to treat icteric hepatitis, Viral hepatitis, cholecystitis, etc., because of their miraculous and unique medicinal effects, Tibetan fungal medicines are called "wonderful works of Tibetan medicine" and are extremely popular in domestic and foreign markets. [0003] At present, the patents related to the medicinal preparation of Tibetan Yinchen are summarized as follows: [0004] Chinese invention patent CN102138966A discloses "Tibetan capillary extract and i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K9/50A61K9/20A61K47/34A61K47/32A61K47/10A61K47/14
CPCA61K9/2081A61K9/5015A61K9/5026A61K36/51A61K47/10A61K47/32A61K47/34
Inventor 王亚轩任雅孜
Owner 西安远大德天药业股份有限公司