Unlock instant, AI-driven research and patent intelligence for your innovation.

Method for synthesizing liquid crystal medium

A technology of liquid crystal medium and synthesis method, applied in liquid crystal materials, chemical instruments and methods, etc., can solve the problems of low final yield and low comprehensive yield, etc.

Active Publication Date: 2017-09-01
ZHEJIANG UNIV OF TECH +1
View PDF6 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, light leakage is very common in IPS screens. With the enlargement of the screen, the problem of large-area edge light leakage has always caused IPS panels to be criticized.
[0010] This route has a total of eight steps of reaction, the overall yield is low (3.5%), and dangerous reagents such as liquid bromine and ethylene oxide are used, and toluene is used as the mobile phase of column chromatography in the separation of brominated products. low rate

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for synthesizing liquid crystal medium
  • Method for synthesizing liquid crystal medium
  • Method for synthesizing liquid crystal medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0059] Example 1-1: Preparation of 4'-bromo-2'-ethyl-4-methoxy-[1,1'-biphenyl]-3-carbaldehyde

[0060] Add 3-formyl-4-methoxyphenylboronic acid (5.37g, 30mmol), 4-bromo-2-ethyliodobenzene (9.33g, 30mmol), potassium carbonate (8.28g, 60mmol) into a 250ml two-necked bottle ), toluene 60ml, ethanol 15ml, water 15ml, stirred at room temperature, and replaced nitrogen several times, then added tetrakis (triphenylphosphine) palladium (2.34g, 2.03mmol), stirred at room temperature for 20 minutes, then Heat to 90°C and react for 6 hours, TLC traces until the reactant disappears and the reaction is completed, add an equal amount of water to the reaction solution, extract with ethyl acetate, wash the organic phase with water, dry, concentrate under reduced pressure, and separate by column chromatography to obtain white Solid 6.50g, yield 68%. 1H-NMR (500 MHz, CDCl3) δ 10.51 (s, 1H), 7.75 (d, J = 2.4 Hz, 1H), 7.46 (dd, J = 8.5, 2.4 Hz, 1H), 7.43 (d, J = 2.0 Hz, 1H), 7.34 (dd, J = 8.1, ...

Embodiment 1-2

[0061] Example 1-2: Preparation of 4'-chloro-2'-ethyl-4-methoxy-[1,1'-biphenyl]-3-carbaldehyde

[0062] Add 4-chloro-2-ethylphenyl trifluoromethanesulfonate (8.66g, 30mmol), 4-bromo-2-ethyliodobenzene (9.33g, 30mmol), potassium carbonate ( 8.28g, 60mmol), tetrahydrofuran 90ml, stirred at room temperature, and replaced nitrogen several times, then added [1,1'-bis(diphenylphosphino)ferrocene]palladium dichloride (1.76g, 2.40 mmol), stirred at room temperature for 20 minutes, then heated to 110°C for 3 hours, after the reaction was completed, an equal amount of water was added to the reaction solution, extracted with ethyl acetate, the organic phase was washed with water, dried, concentrated under reduced pressure, and Separation by column chromatography yielded 5.27 g of a white solid with a yield of 64%. 1 H-NMR (500 MHz, CDCl3) δ 10.50 (s, 1H), 7.73 (d, J = 2.4 Hz, 1H), 7.42 (dd, J = 8.5, 2.4 Hz, 1H), 7.40 (d, J = 2.0 Hz, 1H), 7.32 (dd, J = 8.1, 1.9 Hz, 1H), 7.02 (d, J = 8.6...

Embodiment 2

[0063] Example 2: Preparation of 2'-ethyl-4-methoxy-4''-pentyl-[1,1':4',1''-terphenyl]-3-carbaldehyde

[0064] Method 1: Add 4'-bromo-2'-ethyl-4-methoxy-[1,1'-biphenyl]-3-carbaldehyde (3.19g, 10mmol) and 4-pentane to a 100ml two-necked bottle Phenylboronic acid (2.88g, 15mmol), potassium carbonate (2.76g, 20mmol), toluene 20ml, ethanol 5ml, water 5ml, stirred at room temperature, and replaced nitrogen several times, then added tetrakis (triphenylphosphine) palladium (0.81g, 0.70mmol), stirred at room temperature for 20 minutes. Then heated to 90°C for 6 hours. After the reaction was completed, an equivalent amount of water was added to the reaction solution, extracted with ethyl acetate, the organic phase was washed with water, dried, concentrated under reduced pressure, and separated by column chromatography to obtain 3.89 g of a white solid with a yield of 99%.

[0065] Method 2: Add 4'-chloro-2'-ethyl-4-methoxy-[1,1'-biphenyl]-3-carbaldehyde (2.75g, 10mmol) and 4-pentane ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for synthesizing a liquid crystal medium. The method comprises the following steps: by taking multi-substituted phenylboronic acid as an initial raw material, performing two-step Suzuki coupling, performing deprotection, performing etherification, performing witting reaction, performing hydroboration oxidation, performing esterification and hydrolysis or acetal hydrolysis, performing aldehyde reduction and the like, thereby obtaining the liquid crystal medium. The method disclosed by the invention has originality, solvents used in different steps of the method are relatively environmental-friendly, simple and convenient to operate and small in production danger factor, and the total yield can be up to 30%, which is much higher than those of methods reported by patents, so that the economic benefits can be greatly increased, and the method is applicable to industrial production.

Description

technical field [0001] The invention relates to a synthesis method of a liquid crystal medium. Background technique [0002] Liquid crystal is an organic substance with a certain order between solid and liquid, and has photoelectric dynamic scattering characteristics; it has a variety of liquid crystal phases, such as cholesteric phase, various smectic phases, and nematic phases. For liquid crystal panels, liquid crystal materials are one of its important components. Currently, liquid crystal panels on the market include TN panels, IPS panels, and VA panels, etc.; [0003] The full name of TN panel is Twisted Nematic (twisted nematic) panel. The low production cost makes TN panel the most widely used entry-level LCD panel, and it is widely used in mainstream low-end LCD monitors on the market. The TN panel is characterized by a fast deflection speed of liquid crystal molecules, so it is easy to improve the response time. However, it is not as good as IPS and VA panels in t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C09K19/12
CPCC09K19/126C09K2019/128
Inventor 俞传明刘永何人宝金逸中
Owner ZHEJIANG UNIV OF TECH