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Industrial preparation method of high purity monomer of lactone components of ginkgo leaf extract

A technology of total ginkgolides and ginkgo leaves, which is applied in the field of industrial preparation of high-purity monomers of lactones in the purified ginkgo leaves, and can solve the problems of long ginkgolide process route, product quality impact, and low separation efficiency , to achieve the effect of short process route, less solvent consumption and high separation efficiency

Active Publication Date: 2017-09-05
SHAANXI SCI TECH UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an industrial preparation method of high-purity monomers of lactones in ginkgo biloba extracts, which solves the problem of long process route, low separation efficiency, large solvent consumption, and problems in the extraction and purification of ginkgolides in the prior art. The existence of the toxic substance ginkgolic acid affects the quality of the product

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] An industrial preparation method for high-purity monomers of lactone components in ginkgo biloba extracts, comprising the following steps:

[0026] Step 1, the pretreatment of raw material: get standard ginkgo leaf extract 1.0kg (the ginkgo extract that meets the quality standard prepared by prior art all can be), total lactone content is 7.12% (containing total lactone about 71.2g) , adding 5.0L deionized water therein, stirring at 70°C until the standard Ginkgo biloba extract is completely dissolved, then adding dilute hydrochloric acid with a concentration of 10% to it, adjusting the pH of the system to 4, and obtaining the pretreated Ginkgo biloba extract;

[0027] Step 2, high-speed countercurrent extraction: pump the pretreated Ginkgo biloba extract into the extraction tower, and then uniformly introduce 7.5L of extraction solvent into the extraction tower for circular high-speed countercurrent extraction, control the extraction temperature at 40°C, and circulate t...

Embodiment 2

[0034] An industrial preparation method for high-purity monomers of lactone components in ginkgo biloba extracts, comprising the following steps:

[0035] Step 1, pretreatment of raw materials: take 1.2kg of standard ginkgo biloba extract, with a total lactone content of 7.12% (containing about 85.44g of total lactone), add 7.2L of deionized water to it, and stir at 60°C to standard The ginkgo leaf extract is completely dissolved, and then 10% dilute hydrochloric acid is added therein to adjust the pH of the system to 4.5 to obtain the pretreated ginkgo leaf extract;

[0036] Step 2, high-speed countercurrent extraction: pump the pretreated Ginkgo biloba extract into the extraction tower, and then uniformly introduce 14.4L of extraction solvent into the extraction tower for circular high-speed countercurrent extraction. The extraction temperature is controlled at 45°C. After 4 times of circular extraction, The extract was obtained, and the extract was concentrated under reduce...

Embodiment 3

[0043] An industrial preparation method for high-purity monomers of lactone components in ginkgo biloba extracts, comprising the following steps:

[0044] Step 1, pretreatment of raw materials: take 1.5kg of standard Ginkgo biloba extract, with a total lactone content of 7.12% (about 106.8g of total lactone), add 10.5L of deionized water to it, and stir at 50°C until the standard The Ginkgo biloba extract is completely dissolved, and then 10% dilute hydrochloric acid is added therein to adjust the pH of the system to 5.0 to obtain the pretreated Ginkgo biloba extract;

[0045] Step 2, high-speed countercurrent extraction: pump the pretreated Ginkgo biloba extract into the extraction tower, and then uniformly introduce 26.25L of extraction solvent into the extraction tower for circular high-speed countercurrent extraction. The extraction temperature is controlled at 50°C, and after 5 times of circular extraction, The extract was obtained, and the extract was concentrated under ...

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Abstract

The invention discloses a preparation method of a high purity monomer of lactone components of a ginkgo leaf extract. The preparation method comprises the following steps: raw material pretreatment, high speed counter-current extraction, vacuum liquid chromatography separation, high performance liquid chromatography (HPLC) separation, and solvent recrystallization. The obtained high purity monomer comprises ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J, ginkgolide M, and bilobalide. The preparation method is simple. The purity of prepared ginkgolides can reach 99% or above. The separation efficiency is high, the solvent consumption is little, and the preparation method is suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical field of chemicals and medicines, and in particular relates to an industrial preparation method of high-purity monomers of lactones in ginkgo biloba extracts. Background technique [0002] Ginkgo biloba, also known as ginkgo tree and Gongsun tree, is a unique tree species in my country. The leaves, fruits and bark of Ginkgo biloba can be used as medicine, especially the leaves have the highest medicinal value. The chemical composition of Ginkgo biloba is relatively complex, and its extract mainly contains flavonoids and terpene lactones, which can expand cardiovascular and cerebrovascular, improve microcirculation, inhibit platelet aggregation, resist oxidation, scavenge and inhibit oxygen free radicals, and delay aging , Antiviral, antibacterial and anti-inflammatory, regulating endocrine disorders and other physiological functions. [0003] Ginkgolides belong to terpenoids, composed of sesquiterpene lactones a...

Claims

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Application Information

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IPC IPC(8): C07D493/22
CPCC07D493/22
Inventor 冯自立赵正栋王峰陈旺屈义虎张辰露何旭龙
Owner SHAANXI SCI TECH UNIV
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