Lycium ruthenicum extract micro-capsule and lycium ruthenicum preparations prepared from same

A technology of Lycium barbarum extract and Lycium nigra, applied in microcapsules, antidote, pill delivery and other directions, can solve the problems such as staying in the research stage of small or pilot test, inconvenient production, transportation and storage, and difficulty in transforming enterprise achievements. , to achieve the effects of enhancing human immunity, high microencapsulation efficiency, and easy industrial production.

Inactive Publication Date: 2017-09-08
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the improvement of living standards and people's awareness of health, wolfberry is increasingly favored by consumers as a healthy food with "medicine and food from the same source". It is required that wolfberry preparations not only have an external brand image, but also Pay attention to the active ingredients of wolfberry, the quality of the preparation, the degree of deterioration during storage, and even the color, aroma, and taste. The most common problem in the preparation of black fruit wolfberry is the hygroscopicity of wolfberry polysaccharides. Transportation and storage have brought many inconveniences, so that many wolfberry products are still in the stage of small-scale or pilot-scale research, and it is difficult to transform the achievements of enterprises. The production process of wolfberry powder, which is relatively mature, is still in the predicament of low industrialization and small production scale.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Preparation of black fruit wolfberry extract: take quantitative black fruit wolfberry fruit, put it in a suitable extraction tank, add water to immerse the medicinal material, the material-liquid ratio is 1:20, soak for 1 hour, heat to 85°C, keep for 45 minutes, separate and extract Liquid and medicinal dregs were extracted 3 times according to the law, and the extracts were combined and concentrated in a rotary evaporator until the relative density of the extract was 1.35.

[0031] 2. Preparation of microcapsules by spray drying method: weigh a certain amount of gelatin, dissolve it with 90% ethanol to make the concentration 2%, mix the wolfberry extract and capsule material solution into a spray liquid in a ratio of 1:3, stir evenly, adjust Spray drying parameters, injection speed (6ml / min), inlet air temperature (130 ℃), fan speed (1400 rpm), atomization pressure (1.5 MPa), spray drying microencapsulation treatment, collected after microencapsulation Lycium barbar...

Embodiment 2

[0034]1. Preparation of black fruit wolfberry extract: take quantitative black fruit wolfberry fruit, put it in a suitable extraction tank, add water to immerse the medicinal materials, the ratio of material to liquid is 1:30, soak for 1.5h, heat to 88°C, keep for 50min, and separate The extract and dregs are extracted 3 times according to the law, and the extracts are combined and concentrated in a rotary evaporator until the relative density of the extract is 1.25.

[0035] 2. Preparation of microcapsules by spray condensation method: disperse the dry powder of Lycium barbarum extract in heated and melted glyceryl monostearate, make a spray liquid at a ratio of 1:2, and carry out spray condensation. The adjustment parameters are: sample injection speed (6 ml / min), freezing temperature (-30°C), fan speed (1800 rpm), and atomization pressure (0.2 MPa), to solidify glyceryl monostearate to form wolfberry extract microcapsules.

[0036] 3. Preparation of black fruit wolfberry gr...

Embodiment 3

[0046] 1. Preparation of Lycium barbarum extract: Take a certain amount of Lycium barbarum fruit, put it in a suitable extraction tank, add water to immerse the medicinal material, the ratio of material to liquid is 1:25, soak for 1.2 h, heat to 90°C, and keep for 55 min. Separate the extract, extract the dregs three times according to the law, combine the extracts, put them in a rotary evaporator and concentrate until the relative density of the extract is 1.3.

[0047] 2. Preparation of microcapsules by spray-drying method: Weigh a certain amount of PLGA, dissolve it with 88% ethanol to make the concentration 3%, make a spray solution of wolfberry extract and capsule material solution in a ratio of 1:3, stir evenly, adjust The parameters of spray drying were as follows: injection speed (8mL / min), inlet air temperature (140 ℃), fan speed (1500 rpm), and atomization pressure (0.5 MPa) to prepare microcapsules.

[0048] 3. Dry granulation and tabletting:

[0049] (1) Mix the m...

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PUM

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Abstract

The invention relates to a lycium ruthenicum extract micro-capsule and lycium ruthenicum preparations prepared from the same. According to the lycium ruthenicum extract micro-capsule, lycium ruthenicum extract is dispersed into capsule materials to form spray liquid, and then the spray liquid is processed through a spray drying method or a spray condensing method to obtain the lycium ruthenicum extract micro-capsule. The lycium ruthenicum extract micro-capsule achieves micro-encapsulation of the prepared lycium ruthenicum extract and improves the bitter taste of lycium ruthenicum, particularly the hygroscopic problem caused by polysaccharide components, thereby improving the quality stability of lycium ruthenicum products, prolonging the shelf life, brining convenience to production, transportation and storage of the lycium ruthenicum products and facilitating large-scale industrial production. Meanwhile, through appropriate granulating processes, micro-encapsulated lycium ruthenicum extract dry powder can be processed into a granulated solid applicable to multiple preparation forms. The lycium ruthenicum extract micro-capsule and the lycium ruthenicum preparations prepared from the same achieve the effects of enhancing body immunity, clearing liver, improving eyesight, delaying senescence, improving sleep and resisting fatigue.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a microcapsule of black wolfberry extract and a wolfberry preparation prepared therefrom. Background technique [0002] Lycium ruthenicum Murr. (Lycium ruthenicum Murr.) is a plant of the genus Lycium L. in the family Solanaceae. It is a unique wild plant resource in the desert area of ​​Northwest my country. Its berries are spherical, purple-black when ripe, and non-toxic. , sweet, known as "soft gold". Lycium barbarum is sweet in taste, flat in nature, and clears away heart-heat. Tibetan medicine calls it "Pangma". It is recorded in Tibetan medicine books such as "Tibetan Medicine" and "Tibetan Medicine Encyclopedia" that it is used to treat heart fever, heart disease, irregular menstruation, menopause and other diseases, and its medicinal effect is obvious; Antihypertensive medicine, black fruit wolfberry is sweet and juicy, rich in vitamins,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K9/20A61K47/42A61K47/14A61K47/34A61K47/36A61K36/815A61P37/02A61P1/16A61P27/02A61P39/06A61P25/20A61P39/00
CPCA61K9/2081A61K9/5015A61K9/5031A61K9/5036A61K9/5057A61K36/815
Inventor 杨建宏韩天燕付亭亭左文宝刘艳华侯延辉
Owner NINGXIA MEDICAL UNIV
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