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Fatigue relieving composition and preparation method and application thereof

A technology for relieving fatigue and composition, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, etc. It can solve the problems of insufficient utilization and waste of resources, and achieve shortened effective time, improved absorption rate, and improved stability. The effect of sex and bioavailability

Inactive Publication Date: 2017-09-08
云南久康生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Other parts of American ginseng medicinal materials cannot be fully utilized, resulting in waste of resources

Method used

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  • Fatigue relieving composition and preparation method and application thereof
  • Fatigue relieving composition and preparation method and application thereof
  • Fatigue relieving composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Preparation of Maca Microencapsulated Powder

[0029] A. Pulverization: Select high-quality maca medicinal materials, send them into a low-temperature gas pulverizer, and pulverize them through a nitrogen stream at -20°C. The powder passes through a 800-mesh sieve to obtain maca fine powder.

[0030] B. Inclusion: Take the prescribed amount of β-cyclodextrin, add water and grind it evenly, then add the maca fine powder prepared in step A, grind it into a paste and dry it at 5°C to obtain the inclusion product.

[0031] C. Solid dispersion: Add 0.5-5% gas-phase micropowder silica gel by weight of the inclusion product to the inclusion product obtained in step B, mix and grind vigorously for 4-5 hours to disperse evenly and form a solid dispersion.

[0032] D. Microencapsulation: Place the solid dispersion prepared in step C in a fluidized bed, take 0.5-2% sodium carboxymethylcellulose according to the weight ratio of the inclusion product, dissolve it in water, and add...

Embodiment 2

[0034] Effect Experiment of Maca Microencapsulated Powder

[0035] (1) Stability test

[0036] 1. Sample preparation: Take a sample from the maca microcapsule powder obtained in Example 1, pack it into a 100g / bag, and mark it as No. ①; get ordinary Maca powder, pack it into a 100g / bag, and mark it as No. ②.

[0037] 2. Place the test sample for 6 months at a temperature of 40°C and a relative humidity of 75%, and perform an accelerated stability test (2010 edition of "Chinese Pharmacopoeia", Part II, P Appendix 200), and test samples at 0 months and 1 month respectively. Month, 2 months, 3 months, 6 months sampling, determination of volatile oil content.

[0038]3. Determination method of volatile oil content: Take 10g each of samples ① and ②, add 100mL water, mix well, connect a volatile oil extractor and a reflux condenser, follow the standard method for volatile oil extraction (Part 1 of the 2010 edition of "Chinese Pharmacopoeia", P Appendix 63 ) for extraction, the e...

Embodiment 3

[0072] Preparation of American Ginseng Extract

[0073] Take clean American ginseng stems, leaves and stems, add ethanol aqueous solution with a volume percentage concentration of 70-80% according to the mass-volume ratio (kg / L) of 1:10, and extract at a temperature of 75°C-80°C for 2.5-3 Hours, continuous leaching 3 times. Concentrate the extract obtained by leaching to 1 / 10 of the original volume, put it on a macroporous adsorption resin, first elute it with an ethanol aqueous solution with a volume percentage concentration of 70-80%, and then elute it with water, and collect the eluate. The two eluents obtained by eluting with alcohol and eluting with water are combined, concentrated and dried to obtain American ginseng extract.

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Abstract

The invention provides a fatigue relieving composition. The fatigue relieving composition consists of maca microcapsule powder, an American ginseng extract and pharmaceutically acceptable auxiliary materials, wherein the maca microcapsule powder is prepared through low-temperature fluid energy milling wall breaking, clathration, solid dispersion and microencapsulation; and the American ginseng extract is prepared by extracting the raw materials of American ginseng stems, leaves and tubers. According to the fatigue relieving composition, the low-temperature fluid energy milling wall breaking technology ensures that maca volatile oil is exposed to the utmost extent and remains in superfine powder, so that absorption and utilization of effective ingredients are facilitated. Compared with raw maca, maca ultrafine powder and common maca preparations, the maca volatile oil has the advantages that the 24-month acceleration stability rate and the absorptivity are remarkably improved, and the effect taking time is obviously shortened. In combination with the functional characteristics of 'reinforcing kidney to strengthen yang' of maca and 'boosting qi and nourishing yin' of American ginseng, the fatigue relieving composition conforms to the traditional Chinese medicine theories of 'reinforcing yin from yang and reinforcing yang from yin', 'mutual assistance of ying and yang' and 'ying and yang balance' and can take the effects of relieving fatigue and improving the physical ability when eaten by people with deficiency of yin, deficiency of yang or deficiency of both ying and yang.

Description

technical field [0001] The invention relates to the technical field of medical care, in particular to a composition for relieving fatigue prepared from maca and American ginseng, a preparation method and application of the composition. Background technique [0002] Fatigue is a normal physiological phenomenon and acts as a protective mechanism for humans. When we feel tired, our body is signaling us that we should rest. If you ignore it, your body will be damaged, and you will eventually become sick from overwork. Life from 9 to 5 every day, physical activities based on muscle activities, or mental activities based on mental and thinking activities, after a certain period of time and to a certain extent, will lead to a decline in mobility, manifested as fatigue or Muscle soreness or general weakness, commonly known as fatigue. In today's society, with the advancement of science and technology and the development of the economy, people's life pressure is increasing, and th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/31A61P39/00A61P1/14
CPCA61K36/258A61K36/31A61K2300/00
Inventor 龙祥刘菲杨文兵
Owner 云南久康生物科技有限公司
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