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Preparation method of chelated calcium capable of accelerating development of skeletal cells

A technology of chelating calcium and cells, which is applied in the field of organic calcium, can solve the problems of low utilization rate and inability to promote the growth and development of bone cells, and achieve the effects of promoting proliferation and growth, improving local microcirculation, and improving the proliferation environment

Inactive Publication Date: 2017-09-22
常州欧利莱照明有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention: Aiming at the problem that the existing chelated calcium for calcium supplementation has high absorption efficiency, but its utilization rate is low and cannot promote the growth and development of bone cells, a chelated calcium for promoting bone cell development is provided. preparation method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0017] First select fresh leaves of Eucommia ulmoides and Panax notoginseng leaves, wash and dry naturally, mix and grind the leaves of Panax notoginseng and Eucommia ulmoides leaves at a mass ratio of 1:5, and pass through a 150-mesh sieve to obtain mixed ball-milled particles, at a mass ratio of 1:10 , mix the mixed ball-milled particles with deionized water, and heat in a water bath at 55°C for 2h; after the heating in the water bath is completed, centrifuge at 2500r / min for 10min, collect the supernatant and place it at 45°C for rotary evaporation to the original volume 1 / 5, to obtain the concentrated solution, according to the volume ratio of 1:8, the concentrated solution was mixed with absolute ethanol, stirred and mixed at room temperature for 1 hour, left to age for 6 hours, filtered to obtain the filtrate, and the filtrate was rotated at 45°C Evaporate to dryness to obtain a dry extract; select 1g of dry extract, 0.1mL Tween-80, and 85mL DMEM cell culture solution in ...

example 2

[0020] First select fresh leaves of Eucommia ulmoides and Panax notoginseng leaves, wash and dry naturally, mix and grind the leaves of Panax notoginseng and Eucommia ulmoides leaves at a mass ratio of 1:5, and pass through a 150-mesh sieve to obtain mixed ball-milled particles, at a mass ratio of 1:10 , mix the mixed ball-milled particles with deionized water, and heat in a water bath at 58°C for 3h; after the heating in the water bath is completed, centrifuge at 2800r / min for 13min, collect the supernatant and put it in a rotary evaporation at 48°C to the original volume 1 / 5, to obtain the concentrated solution, according to the volume ratio of 1:8, the concentrated solution was mixed with absolute ethanol, stirred and mixed at room temperature for 2 hours, left to age for 7 hours, filtered to obtain the filtrate, and the filtrate was rotated at 48°C Evaporate to dryness to obtain a dry extract; select 2g of dry extract, 0.2mL Tween-80, and 93mL DMEM cell culture solution in ...

example 3

[0023] First select fresh leaves of Eucommia ulmoides and Panax notoginseng leaves, wash and dry naturally, mix and grind the leaves of Panax notoginseng and Eucommia ulmoides leaves at a mass ratio of 1:5, and pass through a 150-mesh sieve to obtain mixed ball-milled particles, at a mass ratio of 1:10 , mix the mixed ball-milled particles with deionized water, and heat in a water bath at 60°C for 3h; after the heating in the water bath is completed, centrifuge at 3000r / min for 15min, collect the supernatant and place it at 50°C for rotary evaporation to the original volume 1 / 5, to obtain the concentrated solution, according to the volume ratio of 1:8, the concentrated solution was mixed with absolute ethanol, stirred and mixed at room temperature for 2 hours, left to age for 8 hours, filtered to obtain the filtrate, and the filtrate was rotated at 50°C Evaporate to dryness to obtain a dry extract; select 2g of dry extract, 0.2mL Tween-80, and 100mL DMEM cell culture solution in ...

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PUM

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Abstract

The invention relates to a preparation method of chelated calcium capable of accelerating development of skeletal cells and belongs to the field of organic calcium. The method comprises the steps of mixing folium eucommiae with folium notoginseng, extracting and collecting extracts, wherein the folium eucommiae extract is capable of effectively improving activity of osteoblast and accelerating differentiation and multiplication of osteocytes; the folium notoginseng extract is capable of effectively accelerating regeneration of blood capillaries and improving local microcirculation; through synergistic action of the folium eucommiae extract and the folium notoginseng extract, the multiplication environment of the osteoblast can be improved; the prepared chelated calcium can be compounded with hydroxy calcium phosphate and collagen prepared by calcinations of beef bone and can be prepared into polypeptides through enzymolysis; the chelated calcium is capable of providing calcium sources and collagen polypeptides for differentiation and multiplication of the osteoblast. The chelated calcium disclosed by the invention is high in utilization degree, is capable of improving absorption efficiency and effectively accelerating growth and development of the skeletal cells, and is worthy to be popularized and applied.

Description

technical field [0001] The invention relates to a preparation method of bone cell development-promoting chelated calcium, which belongs to the field of organic calcium. Background technique [0002] Calcium is an important component of the human body and the fifth largest element among various organic and inorganic elements in the human body. Calcium participates in almost all life activities in the human body. The latest scientific research shows that the aging or disease of the human body is closely related to the disorder of calcium metabolism and the change of calcium concentration inside and outside cells. In recent years, more and more people pay attention to the problem of calcium supplementation. An ideal calcium supplement should have the characteristics of high calcium content, high absorption efficiency, no side effects, convenient administration, and good taste. It is more ideal if it contains various amino acids, vitamins, and trace elements needed by the human...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61P3/14A61P19/08A61P19/10A61K33/06A61K36/46
CPCA61K33/06A61K36/258A61K36/46A61K38/014A61K2300/00
Inventor 雷国庆王艳芹
Owner 常州欧利莱照明有限公司