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Shuangjinlian pharmaceutical composition (prepared from flos lonicerae, trollius chinensis and forsythia) and Shuangjinlian atomization inhalation solution as well as preparation methods and application of Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution

A technology of atomization inhalation and composition, applied in the field of medicine, can solve the problems of large dosage and low inhibition rate of viral pneumonia, and achieve the effects of reducing dosage of medicine, improving patient compliance, and avoiding first-pass effect.

Active Publication Date: 2017-10-13
HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent: 011382457, notification number CN1150931C, relates to a Shuangjinlian oral liquid for treating colds and flu and its preparation method. Table, the effect of heat-clearing and detoxification, used for fever, pain, cough and other diseases caused by exogenous wind pathogens and colds, can be used to treat respiratory and lung infections, tonsillitis, pharyngitis, viral pneumonia and influenza, but the patent said The Shuangjinlian oral liquid still has some problems, for example, large dosage, low inhibition rate to viral pneumonia, etc.

Method used

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  • Shuangjinlian pharmaceutical composition (prepared from flos lonicerae, trollius chinensis and forsythia) and Shuangjinlian atomization inhalation solution as well as preparation methods and application of Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution
  • Shuangjinlian pharmaceutical composition (prepared from flos lonicerae, trollius chinensis and forsythia) and Shuangjinlian atomization inhalation solution as well as preparation methods and application of Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution
  • Shuangjinlian pharmaceutical composition (prepared from flos lonicerae, trollius chinensis and forsythia) and Shuangjinlian atomization inhalation solution as well as preparation methods and application of Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation methods of the pharmaceutical composition of Shuangjinlian and the solution for inhalation of Shuangjinlian are as follows:

[0049] a. The four herbs of Lonicera japonica 42%, Nasturtium 8%, Forsythia 14%, Bupleurum 10% are ultra-finely crushed by weight, sieved through a fine sieve of >300 mesh, and put into water at 60℃ After immersing for 2 hours, the medicinal solution is dynamically extracted by pump circulation, and the extracted medicinal solution is dynamically soaked in water at 60℃ for 1.5 hours, then combined with decoction and filtration. When cooled to 60℃, it is concentrated to relative density under vacuum conditions. After it is 1.20 (measured at 80°C), slowly add ethanol when the liquid is cooled to 40°C, and stir fully when the alcohol content reaches 70%. After standing for 12 hours, take the supernatant and reduce Press to recover the ethanol until there is no alcohol taste to obtain an alcohol paste (relative density 1.10, accounting f...

Embodiment 2

[0062] The preparation methods of the pharmaceutical composition of Shuangjinlian and the solution for inhalation of Shuangjinlian are as follows:

[0063] a. According to the weight ratio, 45% of Lonicera japonica, Trollius 5%, Scutellaria baicalensis 30%, Forsythia 10% four herbs are decocted twice in water for 60 minutes each time, filtered, and then combined the filtrate and let stand for 12 hours; Take the supernatant of the filtrate and absorb it on a pre-treated colorless and clear macroporous resin column (flow rate 5ml / min), discard the cleaning solution, and then elute with 85% ethanol. When the yellow ethanol solution flows out, start collecting The eluent does not contain baicalin; then the ethanol is recovered and concentrated to a liquid extract (relative density 1.10, accounting for 8% of the total volume of the atomized inhalation solution to be prepared, (v / v)) for use;

[0064] b. Extract the volatile oil of Bupleurum: Put 10% (by weight) dry powder of Bupleurum i...

Embodiment 3

[0099] a. According to weight ratio, 45% of Lonicera japonica, Nasturtium 5%, Scutellaria baicalensis 30%, Forsythia 10% four herbs are decocted twice in water for 60 minutes each time, filtered, and then combined the filtrate. Concentrate under reduced pressure into a clear paste with a specific gravity of 1.20±0.05 (50°C).

[0100] b. After stirring and mixing the clear paste obtained in a with a certain amount of low-concentration ethanol, slowly add high-concentration ethanol to make the liquid alcohol content reach 60%-80%, let stand for more than 24 hours, filter the supernatant, and Recycle ethanol to obtain alcohol paste

[0101] c. Use steam distillation to extract the volatile oil for 10% of Bupleurum humilis for 3 hours, for use;

[0102] d. Mix the alcohol-reducing cream obtained in b with the volatile oil obtained in c, and add water to make a fixed volume mixture, and dispense it into 10ml / piece or 100ml / bottle specifications.

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Abstract

The invention discloses a Shuangjinlian pharmaceutical composition and Shuangjinlian atomization inhalation solution as well as preparation methods and application of the Shuangjinlian pharmaceutical composition and the Shuangjinlian atomization inhalation solution. The Shuangjinlian pharmaceutical composition is characterized by comprising effective component extracts of 41 to 45 parts of flos lonicerae, 5 to 9 parts of trollius chinensis, 26 to 55 parts of radix scutellariae, 5 to 19 parts of forsythia and 5 to 14 parts of bupleurum in parts by weight. Compared with the honeysuckle, the flos lonicerae used in the raw materials of the invention has an obviously prominent synergistic effect with other medicinal materials in the formula, and the prepared product has an unexpected technical effect in the treatment of upper and lower respiratory tract infection and pneumonia; compared with the conventional Shuangjinlian mixture, the atomization inhalation solution can use a special atomization inhalant dosing device to enter into lungs through respiratory tracts, thereby being small in stimulation for the respiratory tracts, easy in storage, convenient to apply, good in patient compliance, and more ideal in treatment effects.

Description

Technical field [0001] The present invention belongs to the field of medicine. The present invention relates to a pharmaceutical composition of Shuangjinlian, an aerosol inhalation solution of Shuangjinlian, and a preparation method and application thereof. Background technique [0002] Respiratory tract infections and pneumonia are common diseases of the respiratory system. Chinese Patent: 011382457, Announcement No. CN1150931C, relates to a Shuangjinlian oral liquid for the treatment of colds and flu and its preparation method. The formula is composed of five herbs of honeysuckle, forsythia, scutellaria, nasturtium, and Bupleurum. Table, the efficacy of clearing heat and detoxification, used for fever, pain, cough and other symptoms caused by exogenous wind and cold, can be used for the treatment of respiratory and lung infections, tonsillitis, pharyngitis, viral pneumonia and influenza, but the patent says The Shuangjinlian Oral Liquid still has some problems, such as the lar...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/72A61K9/08A61P11/00A61P31/16
CPCA61K9/0078A61K9/08A61K36/233A61K36/355A61K36/539A61K36/634A61K36/71A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2236/53A61K2236/55A61K2300/00
Inventor 张志平郭中华刘伟伟邢泽田其木格张冰冰陈秀平谢春燕赵欢欢
Owner HENAN TALOPH PHARMACEUTICAL STOCK CO LTD
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