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Curcumin loaded antibacterial fibrous membrane and preparation method thereof

An antibacterial fiber and curcumin-loaded technology, which is applied in antibacterial drugs, antifungal agents, fiber treatment, etc., can solve the problems of easy degradation, easy oxidation of phenolic hydroxyl groups of curcumin, and low oral bioavailability, and achieve a simple preparation method , Environmentally friendly effect

Inactive Publication Date: 2017-11-03
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the phenolic hydroxyl groups of curcumin are easily oxidized, easily degraded, poor water solubility and low oral bioavailability, these factors greatly limit the clinical application of curcumin

Method used

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  • Curcumin loaded antibacterial fibrous membrane and preparation method thereof
  • Curcumin loaded antibacterial fibrous membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In this example, we electrospun PLGA–CUR and PLGA / PF127 / CUR fiber membranes.

[0027] Synthetic method of fiber membrane: accurately weigh 800mg PLGA and 80mg CUR with a balance, dissolve them in dichloromethane and methanol (8:2 by volume) so that the mass fraction of PLGA is 14%, and seal the bottle with a sealing film port to prevent solvent evaporation. Stir on a vortex until it is completely dissolved to obtain the spinning dope. Under the conditions of 25° C. and relative humidity of 30-50%, the electrospinning solution was spun with an electrospinning apparatus using latex gloves as a receiver. The applied voltage is 10KV, the receiving distance is 15 cm, the electrospinning liquid is 5 mL, the spinning speed is 0.4 mL / h, and the diameter of the spinneret is 0.51 mm. The organic solvent is volatilized, and the obtained fiber membrane is PLGA–CUR. Such as figure 1 a, b and c are scanning electron micrographs of the fibrous membrane PLGA–CUR.

[0028] Syntheti...

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Abstract

The invention discloses a curcumin loaded antibacterial fibrous membrane and a preparation method thereof. The antibacterial effect of the prepared fibrous membrane on candida albicans, escherichia coli and staphylococcus aureus reaches 93% or higher. The fibrous membrane is composed of an antibacterial agent and a carrier material, wherein curcumin is used as the antibacterial agent, a biodegradable polymer material is used as carrier material, and the two parts are modified by an amphiphilic substance simultaneously. The preparation method has the following specific steps: adding the curcumin, the amphiphilic substance and the biodegradable polymer material into an organic solvent to obtain a spinning solution; spinning the spinning solution with an electrostatic spinning apparatus, and volatilizing the organic solvent to prepare the curcumin loaded antibacterial fibrous membrane. The invention has the advantages that the curcumin loaded antibacterial fibrous membrane is environmentally friendly, the preparation method is simple, the cost is low, and the antibacterial effect reaches 93% or higher.

Description

technical field [0001] The invention belongs to the technical field of drug carriers, and in particular relates to a fiber membrane loaded with antimicrobial drugs and a preparation method thereof. Background technique [0002] Antibacterial fibers generally refer to fibers that have been treated with antibacterial surfaces or mixed with antibacterial agents. They have antibacterial and bactericidal functions against methicillin-resistant Staphylococcus aureus, which can prevent infection and infection. [0003] Curcumin (CUR) is a small molecular natural polyphenolic compound. Modern pharmacological studies have shown that curcumin has general pharmacological activities, including antioxidant, antibacterial and anti-inflammatory. However, the phenolic hydroxyl groups of curcumin are easily oxidized, easily degraded, poor water solubility and low oral bioavailability, these factors greatly limit the clinical application of curcumin. [0004] Poly(lactic-co-glycolic acid), P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/34A61K47/10A61K31/12A61P31/04A61P31/10D04H3/005D04H3/03D01D5/00
CPCA61K9/0002A61K9/7007A61K31/12A61K47/10A61K47/34D01D5/0069D01D5/0076D01D5/0092D04H3/005D04H3/03Y02A50/30
Inventor 肖波马盼盼
Owner SOUTHWEST UNIV
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