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Polylactic acid hybrid biological membrane as well as preparation method and application thereof

A technology of polylactic acid and biofilm, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems that limit the wide application of polylactic acid biofilm, poor body adhesion, and difficult fixation, so as to prevent clinical prevention of tissue adhesion, High porosity, good oral isolation and anti-adhesion effects

Inactive Publication Date: 2017-11-07
青岛杰圣博生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main components of polylactic acid biofilms are polylactic acid and its copolymers, which can meet the clinical requirements for preventing tissue adhesion when used in surgical sites, but the currently used polylactic acid biofilms generally have poor adhesion to the body, are not easy to fix and difficult to operate , limiting the wide application of polylactic acid biofilms

Method used

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  • Polylactic acid hybrid biological membrane as well as preparation method and application thereof
  • Polylactic acid hybrid biological membrane as well as preparation method and application thereof

Examples

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Embodiment 1

[0028] A polylactic acid composite biofilm, wherein the mass ratio of polylactic acid and collagen is 5:1; prepared by electrospinning, the thickness of the polylactic acid composite biofilm is 0.05mm, the thickness accuracy is controlled at ±0.02mm, and the specific surface area is 0.001m 2 / g, there are micropores with a maximum pore diameter of ≤10μm, and a tensile strength of ≥3MPa.

Embodiment 2

[0030] A polylactic acid composite biofilm, wherein the mass ratio of polylactic acid and collagen is 8:1; prepared by electrospinning, the thickness of the polylactic acid composite biofilm is 0.1mm, the thickness accuracy is controlled at ±0.02mm, and the specific surface area is 0.01m 2 / g, there are micropores with a maximum pore diameter of ≤10μm, and a tensile strength of ≥3MPa.

Embodiment 3

[0032] A polylactic acid composite biofilm, wherein the mass ratio of polylactic acid and collagen is 3:2; polylactic acid is racemic polylactic acid, the intrinsic viscosity [η] is 100mL / g, and the weight average molecular weight Mw is 300000; molecular weight distribution 2.0; prepared by freeze-drying method, the thickness of polylactic acid composite biofilm is 0.2mm, the thickness accuracy is controlled at ±0.02mm, and the specific surface area is 0.005m 2 / g, there are micropores with a maximum pore size of ≤10μm, and a tensile strength of ≥3MPa.

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Abstract

The invention discloses a polylactic acid hybrid biological membrane as well as a preparation method and an application thereof. The polylactic acid hybrid biological membrane is made of polylactic acid and collagen in the mass ratio being (1-9):(1:9), the polylactic acid hybrid biological membrane is 0.05-0.2 mm thick, the thickness precision is controlled to be + / -0.02 mm, the specific surface area is 0.001-0.01 m<2> / g, and the membrane has micropores with the largest pore diameter smaller than or equal to 10 mu m and has the tensile strength larger than or equal to 3 MPa. The polylactic acid hybrid biological membrane is made of polylactic acid and collagen, overcomes the defects of high degradation speed, unstable degradation time and fast absorption of collagen and poor adhesion of polylactic acid, is a novel anti-adhesion membrane, has a unique micropore structure, relatively large specific surface area and soft texture and can promote adhesion and proliferation of cells and prevent adhesion without impeding transfer of nutrients.

Description

technical field [0001] The invention relates to the field of biofilm technology, in particular to a polylactic acid composite biofilm and its preparation method and application. Background technique [0002] Dental surgery often requires guided bone regeneration (GBR, Guided Bone Regeneration). Collagen is a component of extracellular matrix and has been widely used in guided bone regeneration. Collagen membrane has good biocompatibility, can promote the proliferation, adhesion, migration and differentiation of osteoblasts, and has barrier functions such as preventing fibroblasts from rapidly invading bone tissue growth sites and separating the growth of soft tissue and hard tissue. However, the currently used collagen membrane degrades and absorbs quickly, has poor strength, high cost, and is easy to cause some inflammation and certain cytotoxicity. [0003] Tissue adhesion after surgery is one of the important medical problems to be solved at home and abroad since the his...

Claims

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Application Information

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IPC IPC(8): C08J5/18C08J3/24C08L67/04C08L89/00A61L31/14A61L31/06A61L31/04A61L27/56A61L27/58A61L27/60A61L27/50A61L27/18A61L27/24
CPCA61L27/18A61L27/24A61L27/50A61L27/56A61L27/58A61L27/60A61L31/044A61L31/06A61L31/14A61L31/146A61L31/148A61L2430/02C08J3/24C08J5/18C08J2367/04C08J2389/00C08J2467/04C08J2489/00C08L67/04C08L89/00C08L2203/16
Inventor 仲学雷金桥刘福强
Owner 青岛杰圣博生物科技有限公司
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