Ultrahigh-drug-loading-capacity hydrogel patch and preparation method thereof

A technology of hydrogel patch and drug loading, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, non-effective ingredients of polymer compounds, etc., which can solve the problems of small drug-loading capacity of hydrogels and achieve drug Strong inclusiveness, comfortable application, good drug release effect

Inactive Publication Date: 2017-11-14
山西海清源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the problem of small drug-loading capacity of existing hydrogels, the

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0010] The preparation method of the super-large drug-loaded hydrogel patch in the embodiment comprises the following steps:

[0011] a. Add drugs to the hydrophilic gel, add drugs and stimulants to the starch water-retaining agent gel, stir evenly for the first time at room temperature, so that the two gels are fully loaded with drugs; Add penetrating agent to the glue, and stir for the second time at room temperature to obtain drug-containing hydrophilic gel and drug-containing starch water-retaining agent gel respectively;

[0012] b. Mix the drug-containing hydrophilic gel, the drug-containing starch water-retaining agent gel and the pre-dissolved drug plant slurry in the mixer, and after the third stirring, the first standing reaction; add surfactant, Tartaric acid solution, stirred for the fourth time and left to stand for the second time to react; then add the mixture of glycerin and sodium polyacrylate and aluminum glycolate solution cross-linking aid, after the fifth ...

Embodiment 1

[0019] A preparation method of a hydrogel patch with a super large drug loading capacity, comprising the following steps:

[0020] a. Add drugs to the hydrophilic gel respectively, add drugs and zinc oxide to the starch water-retaining agent gel, stir evenly for the first time at room temperature, the stirring speed is lower than 40 rpm, and the stirring time is 20 minutes, so that the two The gels were fully loaded with drugs, respectively, and then the penetrant was added to the two gels, and stirred evenly for the second time at room temperature, the stirring speed was 80 rpm, and the stirring time was 8 minutes, respectively to obtain the drug-containing hydrophilic gel, the Medicinal starch water-retaining agent gel; wherein,

[0021] The drug-containing hydrophilic gel includes 65% of the hydrophilic gel, 30% of the drug, and 5% of laurocapram; the hydrophilic gel is composed of the following components: carbomer 3%, gelatin 2%, Drug extract 25%, deionized water 70%; dr...

Embodiment 2

[0025] A preparation method of a hydrogel patch with a super large drug loading capacity, comprising the following steps:

[0026] a. Add drugs to the hydrophilic gel respectively, add drugs and alkali-activated kaolinite powder to the starch water-retaining agent gel, stir evenly for the first time at room temperature, the stirring speed is lower than 40 rpm, and the stirring time is 20 minutes. Make the two gels fully loaded with drugs respectively; add penetrants to the two gels respectively, and stir evenly for the second time at room temperature, the stirring speed is 80 rpm, and the stirring time is 8 min, respectively to obtain the drug-containing hydrophilic gels. Glue, medicated starch water-retaining agent gel; among them,

[0027] The drug-containing hydrophilic gel includes 70% hydrophilic gel, 24% drug, and 6% dimethyl sulfoxide; the hydrophilic gel is composed of the following components: carbomer 6%, gelatin 1% , drug extract 20%, deionized water 73%; drug-cont...

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Abstract

The invention discloses an ultrahigh-drug-loading-capacity hydrogel patch and a preparation method thereof, and relates to the field of hydrogel patches. The ultrahigh-drug-loading-capacity hydrogel patch is prepared from the following raw materials in percentage by mass: 35 to 45 percent of drug-containing hydrophilic gel, 25 to 35 percent of drug-containing starch water retention agent gel, 15 to 25 percent of pre-dissolved drug plant pulp, 0.03 to 0.06 percent of surfactant, 0.2 to 0.25 percent of tartaric acid, 0.1 to 0.2 percent of dihydroxyaluminum aminoacetate cross-linking agent and 7 to 12 percent of mixture, wherein the mixture is prepared by mixing glycerol and sodium polyacrylate according to a proportion of (2 to 4) to 1. The invention also relates to the preparation method of the hydrogel patch. The drug loading capacity of the prepared hydrogel patch reaches 35 percent or above of the total mass of the patch; the ultrahigh-drug-loading-capacity hydrogel patch is multiple in the species of loaded drugs, high in drug inclusiveness and high in drug loading capacity; a horny layer of a skin can be prompted to increase multiplicatively in water quantity by the high water retention performance of the hydrogel patch, swells to be in a porous state, and is more easily penetrated through by a drug; the ultrahigh-drug-loading-capacity hydrogel patch is good in drug release performance and long in acting time.

Description

technical field [0001] The invention relates to the field of hydrogel patches, in particular to a super-large drug-loading hydrogel patch and a preparation method thereof. Background technique [0002] Traditional plaster patches mostly use rubber plaster as the matrix carrier, which generally can only carry fat-soluble drug ingredients, which has relatively large limitations in medication, affects the curative effect and course of treatment, and has poor transdermal absorption effect and is prone to skin allergies. Polymer hydrogel is the most ideal carrier for medical patches. The traditional plaster is replaced with a hydrogel matrix as the carrier, which not only has good permeability, but also has no skin allergies and irritations, and is more comfortable to apply. However, since traditional plasters mostly use traditional Chinese medicine preparations, the drug loading capacity is very large, generally exceeding 30% or even more than 35% of the total mass, while the dr...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/32A61K47/42A61K47/36A61K47/38
CPCA61K9/7023A61K47/32A61K47/36A61K47/38A61K47/42
Inventor 吴震东郝烈爱
Owner 山西海清源生物科技有限公司
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