Ultrahigh-drug-loading-capacity hydrogel patch and preparation method thereof
A technology of hydrogel patch and drug loading, which is applied in the direction of pharmaceutical formulations, medical preparations of non-active ingredients, non-effective ingredients of polymer compounds, etc., which can solve the problems of small drug-loading capacity of hydrogels and achieve drug Strong inclusiveness, comfortable application, good drug release effect
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[0010] The preparation method of the super-large drug-loaded hydrogel patch in the embodiment comprises the following steps:
[0011] a. Add drugs to the hydrophilic gel, add drugs and stimulants to the starch water-retaining agent gel, stir evenly for the first time at room temperature, so that the two gels are fully loaded with drugs; Add penetrating agent to the glue, and stir for the second time at room temperature to obtain drug-containing hydrophilic gel and drug-containing starch water-retaining agent gel respectively;
[0012] b. Mix the drug-containing hydrophilic gel, the drug-containing starch water-retaining agent gel and the pre-dissolved drug plant slurry in the mixer, and after the third stirring, the first standing reaction; add surfactant, Tartaric acid solution, stirred for the fourth time and left to stand for the second time to react; then add the mixture of glycerin and sodium polyacrylate and aluminum glycolate solution cross-linking aid, after the fifth ...
Embodiment 1
[0019] A preparation method of a hydrogel patch with a super large drug loading capacity, comprising the following steps:
[0020] a. Add drugs to the hydrophilic gel respectively, add drugs and zinc oxide to the starch water-retaining agent gel, stir evenly for the first time at room temperature, the stirring speed is lower than 40 rpm, and the stirring time is 20 minutes, so that the two The gels were fully loaded with drugs, respectively, and then the penetrant was added to the two gels, and stirred evenly for the second time at room temperature, the stirring speed was 80 rpm, and the stirring time was 8 minutes, respectively to obtain the drug-containing hydrophilic gel, the Medicinal starch water-retaining agent gel; wherein,
[0021] The drug-containing hydrophilic gel includes 65% of the hydrophilic gel, 30% of the drug, and 5% of laurocapram; the hydrophilic gel is composed of the following components: carbomer 3%, gelatin 2%, Drug extract 25%, deionized water 70%; dr...
Embodiment 2
[0025] A preparation method of a hydrogel patch with a super large drug loading capacity, comprising the following steps:
[0026] a. Add drugs to the hydrophilic gel respectively, add drugs and alkali-activated kaolinite powder to the starch water-retaining agent gel, stir evenly for the first time at room temperature, the stirring speed is lower than 40 rpm, and the stirring time is 20 minutes. Make the two gels fully loaded with drugs respectively; add penetrants to the two gels respectively, and stir evenly for the second time at room temperature, the stirring speed is 80 rpm, and the stirring time is 8 min, respectively to obtain the drug-containing hydrophilic gels. Glue, medicated starch water-retaining agent gel; among them,
[0027] The drug-containing hydrophilic gel includes 70% hydrophilic gel, 24% drug, and 6% dimethyl sulfoxide; the hydrophilic gel is composed of the following components: carbomer 6%, gelatin 1% , drug extract 20%, deionized water 73%; drug-cont...
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