Preparation method for near-infrared light switch fluorescent polymer nanoparticle, and application thereof

A technology of fluorescent polymers and near-infrared light, which is applied in the direction of luminescent materials, chemical instruments and methods, etc., can solve problems such as interference of optical switch fluorescent materials, and achieve the effects of excellent water dispersibility, small particle size, and low cytotoxicity

Active Publication Date: 2017-12-01
HUNAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, among the current photoswitchable fluorophores, such as oxazine compounds, spiropyran compounds and azobenzene compounds are photoswitchable fluorophores concentrated in the visible light region (400-600 nm).
This makes the application of these photoswitchable fluorescent materials in vivo easily disturbed by the background fluorescence of the organism.

Method used

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  • Preparation method for near-infrared light switch fluorescent polymer nanoparticle, and application thereof
  • Preparation method for near-infrared light switch fluorescent polymer nanoparticle, and application thereof
  • Preparation method for near-infrared light switch fluorescent polymer nanoparticle, and application thereof

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Effect test

Embodiment 1

[0039] Embodiment 1: A kind of preparation method of fluorescent polymer nanoparticle of near-infrared optical switch, concrete steps are as follows:

[0040] Methyl methacrylate 0.6g, TEGTPPDI-Aly0.0005g, ethyl-3,3-dimethyl-6-nitroindoline spirothiopyranyl methacrylate (STPMA) 0.020g, n-hexadecane 0.075g and 0.025g of azobisisobutyronitrile were mixed and stirred evenly, then dispersed in 10mL of CTAC aqueous solution with a concentration of 0.005g / mL, ultrasonically emulsified to form a stable and uniform miniemulsion, and reacted at 75°C for 3 hours to obtain near-infrared Photoswitchable fluorescent polymer nanoparticles.

Embodiment 2

[0041] Embodiment 2: A kind of preparation method of fluorescent polymer nanoparticle of near-infrared optical switch, concrete steps are as follows:

[0042] Methyl methacrylate 0.6g, TEGTPPDI-Aly0.0005g, ethyl-3,3-dimethyl-6-nitroindoline spirothiopyranyl methacrylate (STPMA) 0.020g, n-hexadecane 0.075g and 0.025g of azobisisobutyronitrile were mixed and stirred evenly, dispersed in 10mL of CTAC aqueous solution with a concentration of 0.01g / mL, ultrasonically emulsified to form a stable and uniform fine emulsion, and reacted at 75°C for 3 hours to obtain near-infrared Photoswitchable fluorescent polymer nanoparticles.

Embodiment 3

[0043]Embodiment 3: A kind of preparation method of fluorescent polymer nanoparticle of near-infrared optical switch, concrete steps are as follows:

[0044] Methyl methacrylate 0.6g, TEGTPPDI-Aly0.0005g, ethyl-3,3-dimethyl-6-nitroindoline spirothiopyranyl methacrylate (STPMA) 0.020g, n-hexadecane 0.075g and 0.025g of azobisisobutyronitrile were mixed and stirred evenly, dispersed in 10mL of CTAC aqueous solution with a concentration of 0.015g / mL, ultrasonically emulsified to form a stable and uniform miniemulsion, and reacted at 75°C for 3 hours to obtain near-infrared Photoswitchable fluorescent polymer nanoparticles.

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Abstract

The invention discloses a preparation method for a near-infrared light switch fluorescent polymer nanoparticle, and application thereof. A FRET (Fluorescence Resonance Energy Transfer) principle is used, MMA (Methyl MethAcrylate) is taken as a polymerizable monomer, polymerizable near infrared fluorescent dye (TEGTPPDI-Aly) is taken as an energy donor, a polymerizable photochromic compound (STPMA) is taken as an energy receptor, hexadecane (HD) is taken as a hydrophobic substance, CTAC (Cetyltrimethylammonium Chloride) is taken as surfactant, and a one-step simple miniemulsion polymerization method is adopted to prepare the near-infrared light switch fluorescent polymer nanoparticle. The near-infrared light switch fluorescent polymer nanoparticle prepared with the predation method has the advantages of near-infrared light switch ability, low cytotoxicity, good water dispersibility, low input cost, simple synthetic route and the like, is suitable for amplification synthesis and practical production and application, and has a huge application prospect in technical field including super-resolution imaging, life science and the like.

Description

technical field [0001] The invention belongs to the field of preparation, analysis and detection of chemical materials, and relates to the preparation and application of near-infrared reversible light-switching fluorescent polymer nanoparticles, in particular to the preparation and application of near-infrared light-switching fluorescent polymer nanoparticles. Background technique [0002] In the past 20 years, responsive functional polymer materials have received more and more attention. Responsive functional polymer materials generally refer to external stimuli such as changes in pH, temperature, external force, magnetic field, light, or comprehensive The effect leads to reversible or irreversible changes in the physical properties or chemical structure of the material. Its applications involve drug release to tissue repair, as well as biosensors, chemical sensors and other fields. Recent research efforts focus on the design and synthesis of new functional polymer materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/14C08F222/26C08F220/40C08F2/28C09K11/06
CPCC08F2/28C08F220/14C09K11/06C09K2211/1466C08F222/1063C08F220/40
Inventor 陈建王宏张媛邹朝张培盛洪永想
Owner HUNAN UNIV OF SCI & TECH
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