Polypeptide, immunogenicity conjugate and influenza vaccine

A technology for immunogenicity and influenza vaccines, which is applied in the field of immunogenic conjugates, influenza vaccines, and peptides, can solve the problems of poor immunogenicity and small molecular weight, and achieve the effect of improving survival rate
CN107488218AActive Publication Date: 2017-12-19华兰生物疫苗股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
华兰生物疫苗股份有限公司
Publication Date
2017-12-19

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Abstract

The invention discloses a polypeptide, an immunogenicity conjugate and an influenza vaccine, and relates to the bio-technical field. The polypeptide is any one of a), b) or c): a) a polypeptide with the amino acid sequence as shown in SEQ ID NO.1; b) fused protein obtained by connecting a label to the end N and / or the end C of the polypeptide with the amino acid sequence as shown in SEQ ID NO.1; c) a polypeptide which is obtained by substitution and / or deletion and / or adding of one or several amino acid residues for the amino acid sequence as shown in SEQ ID NO.1 and has the same function. The polypeptide can be used for preventing or treating influenza virus, and can be used as an active component for preparing a medicine for preventing or treating the influenza virus. The immunogenicity conjugate disclosed by the invention can improve the immunogenicity and the immune effect on an antigen at a conformational dependency site.
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Description

technical field

[0001] The invention relates to the technical field of biotechnology, in particular to a polypeptide, an immunogenic conjugate and an influenza vaccine. Background technique

[0002] Influenza A virus is a common influenza virus. Influenza A virus is the most likely to mutate. The subtype of influenza A virus is called "bird flu". Bird flu (Bird Flu) is caused by bird flu virus. Acute infectious disease, virus gene mutation can infect human beings, the main symptoms after infection are high fever, cough, runny nose, myalgia, etc. Most of them are accompanied by severe pneumonia. In severe cases, heart, kidney and other organ failure lead to death , the fatality rate is high. Influenza A is highly pathogenic to humans and has caused worldwide pandemics many times. Among the influenza A viruses, the subtypes of avian influenza viruses that can directly infect humans have been found so far: A H1N1, H5N1, H7N1, H7N2, H7N3, H7N7, H7N9, H9N2 and H10N8. Among the...

Claims

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