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Peripheral drug-eluting stent and its preparation and application

A technology for eluting stents and drugs, applied in the fields of medical science, surgery, coating, etc., can solve the problems of affecting the efficacy of peripheral drug-eluting stents, poor sustained release effect, etc., to prevent restenosis, prevent early burst release, strong effect of drug action

Active Publication Date: 2020-12-08
北京永益润成科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] With the wide application of drug-eluting stent systems and the continuous development of new technologies, peripheral drug-eluting stents are now used instead of bare-metal stents in peripheral vascular interventional therapy. A serious shortcoming of the stent is the "burst release" phenomenon, that is, the drug release amount reaches about 70% within 24 hours after the stent is implanted, and the effective drug concentration in the subsequent release period is obviously insufficient, which seriously affects the peripheral drugs. Efficacy of Eluting Stents

Method used

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  • Peripheral drug-eluting stent and its preparation and application
  • Peripheral drug-eluting stent and its preparation and application
  • Peripheral drug-eluting stent and its preparation and application

Examples

Experimental program
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Effect test

Embodiment 1

[0038] For the three peripheral drug-eluting stents provided in this embodiment, three layers of drug coatings are respectively sprayed on the outer sides of the three bare metal stents. The specific preparation of peripheral vascular stents 1, 2, and 3 is as follows:

[0039] Preparation of spray solution for stent 1:

[0040] Drug configuration for the outer layer of the drug stent: weigh 10 mg of PLGA (molecular weight 30,000, PLA:PGA=70:30), add 10 ml of tetrahydrofuran, and stir magnetically for 30-60 minutes to completely dissolve the polymer;

[0041] Drug configuration in the middle layer of the drug stent: Weigh 20mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and stir magnetically for 30-60min to completely dissolve the polymer;

[0042] Drug configuration in the inner layer of the drug stent: Weigh 20 mg of PTX and 10 mg of PLGA (molecular weight 20,000, PLA:PGA=80:20), add 10 ml of tetrahydrofuran respectively, a...

Embodiment 2

[0054] For the three peripheral drug-eluting stents provided in this embodiment, three layers of drug coatings are respectively sprayed on the outer sides of the three bare metal stents. The specific preparation of peripheral vascular stents 4, 5, 6 is as follows:

[0055] Preparation of spraying liquid medicine for bracket 4:

[0056] Drug configuration for the outer layer of the drug stent: weigh 10 mg of PLGA (molecular weight 20,000, PLA:PGA=70:30), add 10 ml of tetrahydrofuran, and stir magnetically for 30-60 minutes to completely dissolve the polymer;

[0057] Drug configuration in the middle layer of the drug stent: weigh 30mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and stir magnetically for 30-60min to completely dissolve the polymer;

[0058] Drug configuration in the inner layer of the drug stent: Weigh 30 mg of PTX and 10 mg of PLGA (molecular weight 20,000, PLA:PGA=80:20), add 10 ml of tetrahydrofuran respect...

Embodiment 3

[0070] For the three peripheral drug-eluting stents provided in this embodiment, three layers of drug coatings are respectively sprayed on the outer sides of the three bare metal stents. The specific preparation of peripheral vascular stents 7, 8, 9 is as follows:

[0071] Preparation of the spraying solution of the stent 7:

[0072] Drug configuration for the outer layer of the drug stent: weigh 10 mg of PLGA (molecular weight 30,000, PLA:PGA=70:30), add 10 ml of tetrahydrofuran, and stir magnetically for 30-60 minutes to completely dissolve the polymer;

[0073] Drug configuration in the middle layer of the drug stent: weigh 30mgPTX and 10mgPLGA (molecular weight 20000, PLA:PGA=50:50), add 10ml tetrahydrofuran respectively, and stir magnetically for 30-60min to completely dissolve the polymer;

[0074] Drug configuration in the inner layer of the drug stent: Weigh 30 mg of PTX and 10 mg of PLGA (molecular weight 20,000, PLA:PGA=80:20), add 10 ml of tetrahydrofuran respectiv...

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Abstract

The invention provides a peripheral drug eluting stent. A drug coating of the peripheral drug eluting stent is divided into an outer sustained-release layer, an intermediate drug sustained-release mixed layer and an inner drug sustained-release mixed layer. The outer sustained-release layer is PLGA with molecular weight being 30000, and PLA:PGA=70:30. The intermediate drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=50:50, and the mass ratio of PTX to PLGA is 3:1. The inner drug sustained-release mixed layer is a mixture of PTX and PLGA, wherein the molecular weight of PLGA is 20000, PLA:PGA=80:20, and the mass ratio of PTX to PLGA is 3:1. The invention further relates to preparation and application of the peripheral drug eluting stent. The peripheral drug eluting stent can effectively treat peripheral artery stenosis, and the problem of in-stent restenosis after a traditional peripheral bare metal stent is implanted into the peripheral vessel is avoided.

Description

technical field [0001] The invention relates to a peripheral drug-eluting stent and its preparation and application. Background technique [0002] The incidence of peripheral vascular disease has increased significantly in recent years, common such as arteriosclerotic obliterans, arteriovenous thrombosis and so on. At present, the professional technology for the treatment of peripheral vascular diseases in my country is developing vigorously, the traditional surgical techniques are constantly being improved, and the clinical application of interventional therapy methods is also becoming more and more extensive. The clinical application of self-expandable peripheral vascular stent is an important milestone in the treatment of peripheral vascular stenosis. However, the problem of in-stent restenosis after many traditional peripheral bare metal stents are implanted in peripheral blood vessels becomes more and more obvious. According to statistics, the medium and long-term res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/16A61L31/10A61L31/14B05D3/02B05D3/04B05D7/00
CPCA61L31/10A61L31/148A61L31/16A61L2300/216A61L2300/416A61L2300/604A61L2300/608A61L2420/06A61L2420/08B05D3/0254B05D3/0493B05D7/582C08L67/04
Inventor 周挺果艳东石培国胡堃赵艳
Owner 北京永益润成科技有限公司
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