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Skin expander with VEGF slow-release PCL coatings and manufacturing method thereof

A technology of skin expansion and production method, which is applied in the direction of dilators, coatings, and medical devices, which can solve the problems of uneven effect area, high technical difficulty in operation, and unsustainable effect, so as to promote the formation of new blood vessels and shorten the expansion Time, the effect of reducing blood flow disorder

Active Publication Date: 2017-12-22
上海威宁整形制品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(①Li Q F, Reis E D, Zhang W X, et al. Accelerated flap prefabrication with vascular endothelial growth factor [J]. Journal of reconstructive microsurgery, 2000, 16(01): 0045-0050; ② Khan A, Ashrafpour H, Huang N, et al. al.Acute local subcutaneous VEGF 165 injection for augmentation of skin flap viability:efficacy and mechanism[J].American Journal of Physiology-Regulatory,Integrative and Comparative Physiology,2004,287(5):R1219-R1229.) However, the administration methods are Subcutaneous injection or surface application, the effect area is uneven, the effect is not long-lasting, it needs to be administered multiple times, and the operation is complicated
At the same time, the subcutaneous injection method is easy to cause damage to the water bladder of the dilator, and the operation technique is difficult and risky
Therefore, the use of VEGF in actual clinical practice is limited

Method used

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  • Skin expander with VEGF slow-release PCL coatings and manufacturing method thereof
  • Skin expander with VEGF slow-release PCL coatings and manufacturing method thereof
  • Skin expander with VEGF slow-release PCL coatings and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 Expansion capsule is a cuboid skin expander with VEGF slow-release PCL coating

[0048] Such as Figure 6 As shown, a skin dilator with a VEGF slow-release PCL coating of the present invention is composed of three parts: an expansion bag 9, an aqueduct 8, and an injection valve 7; the main materials of the three parts of the expansion bag, aqueduct, and injection valve are Medical silicone. One end of the aqueduct 8 is fixedly connected to the injection valve 7, and the other end is fixed to the bottom of the expansion bag 9, and the connection between the aqueduct 8 and the expansion sac 9 is a built-in type (that is, the end of the aqueduct 8 is contained in the expansion bag 9 , integrated with the expansion bag 9), therefore, the interface will not cause additional compression to the bottom tissue during expansion.

[0049] Such as figure 1 , figure 2 , image 3 , Figure 4 Shown, the profile of expansion bag 3 is a cuboid that is long 8R, wide ...

Embodiment 2

[0064] Example 2 The skin dilator with VEGF slow-release PCL coating with dilatation capsule as cube

[0065] A VEGF slow-release PCL-coated skin dilator of the present invention consists of three parts: an expansion bag, an aqueduct, and an injection valve; the main materials of the three parts are medical silica gel.

[0066] The shape of the expansion bag is a cube with a length of 4R, a width of 4R, and a height of 4R; R is 1.5-2cm; The surface (except the bottom surface) is additionally provided with a VEGF slow-release PCL coating.

[0067] The length of the aqueduct is 8cm, the inner diameter of the aqueduct is 1mm, and the outer diameter is 2mm. One end of the aqueduct is fixedly connected to the injection valve, and the other end is fixed to the bottom of the expansion sac. The connection between the aqueduct and the expansion sac is inclusive (that is, the end of the aqueduct is contained in the expansion sac and integrated with the expansion sac) , Therefore, the ...

Embodiment 3

[0081] Embodiment 3 The expansion bag is a skin dilator with a VEGF slow-release PCL coating of a custom-made ellipsoid

[0082] A VEGF slow-release PCL-coated skin dilator of the present invention consists of three parts: an expansion bag, an aqueduct, and an injection valve; the main materials of the three parts are medical silica gel.

[0083] According to the measurement of the patient's lesion area, the shape of the custom-made expansion sac coated with VEGF sustained-release PCL is an ellipsoid with a length of 8R, a width of 4R, and a height of 2R, with a long distance between the front and rear ends and a short distance between the left and right ends; The outer surface (except the bottom surface) of the expansion bag housing is additionally provided with a VEGF slow-release PCL coating; R is 1.5-2 cm.

[0084] The length of the aqueduct is 12cm, the inner diameter of the aqueduct is 3mm, and the outer diameter is 4mm. One end of the aqueduct is fixedly connected to t...

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Abstract

The invention discloses a skin expander with VEGF slow-release PCL coatings and a manufacturing method thereof. The skin expander comprises an expander capsule, a water manifold and an injection valve; one end of the water manifold is fixedly connected with the injection valve, and the other end of the water manifold is fixed to the bottom of the expander capsule; the expander capsule housing is prepared by a plurality of medical silica gel layers, and external surfaces (except the bottom surface) of the expander capsule housing are additionally provided with the VEGF slow-release PCL coatings; and the VEGF slow-release PCL coatings are additionally installed in a manner of pouring by using PCL and silica gel and then dip-coating by using heparin / VEGF. According to the VEGF slow-release PCL coating expander, VEGF slow-release PCL coatings are additionally installed on external surfaces of a housing of a traditional expander, VEGF stimulation with effective concentration can be uniformly and continuously given to the whole skin at the external surfaces of the expander capsule housing during the whole period of embedding the expander, angiogenesis of expanded flaps is promoted, and therefore expanding speed can be accelerated, and generation of postoperative flap avascular necrosis can be prevented.

Description

technical field [0001] The invention belongs to the technical field of plastic surgery and relates to a dilator, in particular to a skin dilator with a VEGF slow-release PCL coating and a manufacturing method thereof. Background technique [0002] Skin and soft tissue expansion, referred to as skin expansion, refers to implanting a skin and soft tissue expander (abbreviated as expander) under the normal skin and soft tissue, and injecting liquid into the expansion bag through the injection valve to increase the capacity of the expander and make it more sensitive to the surface. The skin soft tissue generates pressure, and through the expansion mechanism, the division and proliferation of tissue and epidermal cells and the expansion of cell gaps are caused by the expansion mechanism, thereby increasing the skin area and obtaining repairs that match the color, texture, structure, and hair of the skin to the recipient area. Material. Existing clinically used dilators are mostl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M29/04A61M25/10A61B90/00A61L31/16
CPCA61L31/16A61L2300/252A61L2300/414A61L2300/602A61L2300/606A61L2420/02A61M25/1002A61M25/1029A61M29/02A61M2025/1031A61M2025/105A61M2205/0238A61M2210/04A61B90/02
Inventor 王智超昝涛李青峰李海洲黄昕徐祥文高雅姗胡赞喜
Owner 上海威宁整形制品有限公司
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