Preparation method and application of antibacterial cellulose ester

An antibacterial fiber and cellulose technology, which is used in medical science, bandages, absorbent pads, etc., can solve the problems of uneven separation effect of membranes, samples cannot enter the separation membrane, and the separation effect cannot be achieved, and achieve lasting and stable antibacterial performance, The effect of good antibacterial effect with little change in decomposition temperature range

Active Publication Date: 2017-12-26
深圳市菩安科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cheng Chi et al. conducted an experimental analysis of the problems that often occur in the separation of serum proteins by cellulose acetate membranes, and obtained the factors that affect the electrophoretic spectrum. , resulting in different brittleness of the membrane, resulting in uneven separation effect of the entire membrane d

Method used

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  • Preparation method and application of antibacterial cellulose ester
  • Preparation method and application of antibacterial cellulose ester
  • Preparation method and application of antibacterial cellulose ester

Examples

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Effect test

Embodiment 1

[0050] A kind of preparation method of antibacterial cellulose ester:

[0051] (1) Take 1 g of cellulose diacetate (CDA), 0.36 g of phthalic anhydride in an equimolar amount, and 3.38 mL of catalyst triethylamine. The molar amount of the catalyst is 10 times the hydroxyl content of cellulose diacetate. First, dissolve 1g of cellulose diacetate in a 100mL three-necked round-bottomed flask filled with 20mL of acetone solution, put it on a magnetic stirrer, heat and stir at 60°C for about 2h, and raise the temperature to 65°C. After the cellulose acetate was completely dissolved, 0.36 g of phthalic anhydride and 3.38 mL of catalyst triethylamine were added to react for 24 hours. After the reaction, the reaction solution was slowly dropped into 100mL of absolute ethanol to precipitate and wash 3 times, and the esterified product was obtained by suction filtration, and the obtained esterified product was vacuum-dried at 40°C for 8 hours to obtain cellulose diacetate and acid anhydr...

Embodiment 2

[0057] A kind of preparation method of antibacterial cellulose ester:

[0058] (1) Weigh 1 g of purified cellulose diacetate, 0.25 g of equimolar amount of succinic anhydride, and 3.38 mL of catalyst triethylamine. The molar amount of the catalyst is 10 times the hydroxyl content of cellulose diacetate. First, dissolve 1g of cellulose diacetate in a 100mL three-necked round-bottomed flask filled with 20mL of acetone solution, heat and stir for about 2 hours at 60°C on a magnetic stirrer, and raise the temperature to 65°C. After the cellulose was completely dissolved, 1.98 g of succinic anhydride and 3.38 mL of catalyst triethylamine were added to react for 24 hours. After the reaction, the reaction solution was slowly dropped into 100mL of absolute ethanol to precipitate and wash 3 times, and the esterified product was obtained by suction filtration, and the obtained esterified product was vacuum-dried at 40°C for 8 hours to obtain cellulose diacetate and Succinic anhydride g...

Embodiment 3

[0064] A kind of preparation method of antibacterial cellulose ester:

[0065] (1) Take 1 g of cellulose diacetate (CDA), 1.34 g of stearic anhydride (SA) in equimolar amounts, and 3.38 mL of catalyst triethylamine. Dissolve cellulose diacetate in 20mL of acetone solution, heat and stir on a magnetic stirrer at 60°C, the temperature rises to 65°C, after the cellulose diacetate is completely dissolved, add 1.34g of stearic anhydride, catalyst triethyl Amine 3.38mL, reacted for 10 hours.

[0066] (2) Add 0.1g N-hydroxysuccinimide (NHS), 0.15g 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC), 0.3g levofloxacin In 10mL DMF solution, activate overnight under ice bath conditions, add 0.13g Boc-EDA to react for 12h, then add 0.1g trifluoroacetic acid to remove Boc, add dropwise 0.3mL triethylamine to adjust pH after 1h, stir for 1h;

[0067] (3) Dissolve 0.3g of the esterified product CDA-g-SA in 10mL of DMF solution, add 0.1g of N-hydroxysuccinimide (NHS), 0.15g o...

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Abstract

The invention discloses a preparation method of antibacterial cellulose and application of the obtained antibacterial cellulose in preparing antibacterial fiber surgical dressing. The preparation method comprises the following steps: purifying a cellulose derivative; adding the purified cellulose derivative and acid anhydride into an acetone solution in the presence of a catalyst, heating, and stirring; activating hydroxyl in an ester, washing precipitates in absolute ethyl alcohol, performing suction filtering to obtain the ester, and obtaining a grafted ester; grafting ethylenediamine protected by di-tert-butyl dicarbonate ester and a broad-spectrum antibacterial agent; and enabling the ester to have esterification with a product, thus obtaining the antibacterial cellulose. The prepared esterification product is high in moisture absorption, a modified product of a grafted antibacterial agent has good antibacterial effect for negative and positive bacteria, the medical dressing not only can play a bacteriostatic effect when in bacterial infection, can avoid the breeding of the bacteria, also has the advantage of water resistance and water permeability, and can well protect a wound area.

Description

technical field [0001] The invention relates to the esterification modification and antibacterial performance research of cellulose diacetate, in particular to the preparation of an electrospun antibacterial fiber and its application in the field of medical dressings. Background technique [0002] Acetate fiber has a luster and feel similar to silk, and is often used as a substitute for silk, as the lining of skirts or coats, and blended with synthetic fibers to produce composite yarns for various high-end clothing. In addition to being used in textiles, acetate fiber is also widely used in medical dressings, cigarette filters and other fields. [0003] Because CA fiber has hydrophilic properties and good hygroscopic properties, it is especially suitable for anti-inflammatory and antibacterial gauze, wound dressings, etc. In a humid environment, various bacteria are easy to breed on the surface of the wound, and the gauze made of CA material can avoid excessive moisture and...

Claims

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Application Information

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IPC IPC(8): C08B15/06A61L15/46A61L15/20A61L15/28A61L15/42
CPCA61L15/20A61L15/28A61L15/42A61L15/46A61L2300/216A61L2300/404C08B15/06C08L1/08
Inventor 吴德群汤双双朱婕韩华李发学王学利俞建勇杨占平曹建华陈昀
Owner 深圳市菩安科技有限公司
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