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Human placenta lyophilized powder preparation and preparation method thereof

A technology of freeze-dried powder and human placenta, which is applied in freeze-dried transportation, powder transportation, digestive system, etc. It can solve the problems of difficulty in exerting the efficacy of active molecules and loss of efficacy of biologically active substances, so as to avoid the risk of microbial growth and fully extract Intact, less digestive loss effect

Inactive Publication Date: 2017-12-29
SHAANXI STEM CELL ENG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the freeze-drying method disclosed in the Chinese patent application with publication number 104894201A improves the active ingredients through enzymatic hydrolysis, the termination process still adopts a high temperature of 95°C, which also causes a large number of biologically active substances to lose their efficacy while terminating the action of the enzyme.
In addition, in the prior art, most of the placenta is directly frozen into freeze-dried powder by freeze-drying method. When eating, the active substances pass through the stomach and most of them are digested and absorbed, which also makes it difficult to exert the efficacy of active molecules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Preparation of human placenta freeze-dried powder preparation

[0024] Proceed as follows:

[0025] (1) Collect healthy placenta with natural delivery and gestational age less than 29 weeks. During the collection process, wash the placenta with 1000ml of 0.9% normal saline; disinfect the surface of the cleaned placenta with 75% alcohol, and then rinse with 500ml of normal saline Drain the cleaned and disinfected placenta and put it into a sterile sampling bag, and add 1000ml of PBS buffer solution to the sampling bag, and then seal the sampling bag; Transport to the preparation site within 22 hours at 20°C;

[0026] (2) Take out the placenta, rinse with 4°C normal saline and disinfect the surface of the placenta with alcohol, remove the fascia and blood vessels, put it in a NaCl solution with a mass concentration of 10%, soak it for 5 hours, and take it out;

[0027] (3) Shred the placenta (cut into about 3-5cm 3 small pieces) were subjected to low-temperat...

Embodiment 2

[0032] Example 2 Preparation of human placenta freeze-dried powder preparation

[0033] Proceed as follows:

[0034] (1) Collect healthy placenta with natural delivery and gestational age less than 29 weeks. During the collection process, wash the placenta with 1000ml of 0.9% normal saline; disinfect the surface of the cleaned placenta with 75% alcohol, and then rinse with 500ml of normal saline Drain the cleaned and disinfected placenta and put it into a sterile sampling bag, and add 1000ml of PBS buffer solution to the sampling bag, and then seal the sampling bag; Transport to the preparation site within 22 hours at 20°C;

[0035] (2) Take out the placenta, rinse with 4°C normal saline and disinfect the surface of the placenta with alcohol, remove the fascia and blood vessels, put it in a NaCl solution with a mass concentration of 10%, soak it for 5 hours, and take it out;

[0036] (3) Shred the placenta (cut into about 3-5cm 3 small pieces) were subjected to low-temperat...

Embodiment 3

[0041] Example 3 Preparation of human placenta freeze-dried powder preparation

[0042] Proceed as follows:

[0043] (1) Collect healthy placenta with natural delivery and gestational age less than 29 weeks. During the collection process, wash the placenta with 1000ml of 0.9% normal saline; disinfect the surface of the cleaned placenta with 75% alcohol, and then rinse with 500ml of normal saline Drain the cleaned and disinfected placenta and put it into a sterile sampling bag, and add 1000ml of PBS buffer solution to the sampling bag, and then seal the sampling bag; Transport to the preparation site within 22 hours at 20°C;

[0044] (2) Take out the placenta, rinse with 4°C normal saline and disinfect the surface of the placenta with alcohol, remove the fascia and blood vessels, put it in a NaCl solution with a mass concentration of 10%, soak it for 5 hours, and take it out;

[0045] (3) Shred the placenta (cut into about 3-5cm 3 small pieces) were subjected to low-temperat...

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Abstract

The invention discloses a preparation method of a human placenta lyophilized powder preparation. The preparation method comprises: taking human placenta, washing to remove fascia and vessels, soaking in NaCl solution having a mass concentration of 10% for 5 h, chopping the human placenta, and performing low-temperature tissue homogenizing to obtain human placenta homogenate; mixing the homogenate with purified water, acquiring active factors in tissues and cells via a hypotonic method, and stirring for extracting to obtain tissue liquid; adding 0.8-2% of yeast powder for fermenting, and removing smell of the finished product; filtering with a 30-70 Mu m filter membrane to obtain human placenta liquid extract; lyophilizing to obtain human placenta lyophilized powder; packaging with capsule shells (HPMCAS or CAP) to obtain the human placenta lyophilized powder preparation. According to the preparation method, hypotonic homogenizing treatment is performed first, and yeast fermenting and smell removing are performed then before lyophilizing to obtain human placenta active material lyophilized powder that is made into capsules; the preparation method has the advantages that, for instance, nutrients are extracted fully and completely under high efficiency, the preparation is smellless, and the biological active ingredients are easy to absorb; a practicable technique for using human placenta resources to produce high-added-value nutrient health products is provided, and has a promising industrialization prospect.

Description

technical field [0001] The invention relates to a human placenta freeze-dried powder preparation and a preparation method thereof. Background technique [0002] Placenta, also known as purple river car, afterbirth, afterbirth and so on. Traditional Chinese medicine has always regarded placenta as an important medicine. Chinese medicine believes that Zihe Che has a sweet and salty taste, warm air, and is non-toxic. It is a medicine for invigorating the deficiency of both yin and yang, and has the effect of reversing the root and returning the essence. It is used to treat all deficiency and damage, loss of vigor and thinness, labor heat and bone steaming, nocturnal emission and night sweats, women's blood deficiency, impotence, infertility and other diseases. [0003] Now medical tests have found that the placenta is rich in various antibodies, interferon, β-inhibitory factors, fibrin stabilization factors similar to blood coagulation factor VIII, urokinase inhibitors, plas...

Claims

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Application Information

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IPC IPC(8): A61K35/50A61K9/19A61K9/48A61P1/14A61P15/10A61P15/08
CPCA61K9/19A61K9/48A61K35/50
Inventor 陈小威徐峰波初相伍周西峰胡少涛刘静田雨李星吉周丹丹
Owner SHAANXI STEM CELL ENG CO LTD
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