Gold nanorod chirality structure construction method and detection method of copper ions

A technology of gold nanorods and chiral structure, which is applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems caused by Alzheimer's disease, Parkinson's disease, etc., and achieve low-cost, non-toxic, Simple steps and high reproducibility

Active Publication Date: 2014-07-23
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Copper ion is an essential transition metal ion in animals and plants, but excessive copper ions can lead to many serious consequences, such as Alzheimer's disease, Parkinson's disease, etc. (Liu, X.; Zhang, N.; Bing, T.; Shangguan, D., Carbon Dots Based Dual-Emission Silica Nanoparticles as a

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  • Gold nanorod chirality structure construction method and detection method of copper ions
  • Gold nanorod chirality structure construction method and detection method of copper ions
  • Gold nanorod chirality structure construction method and detection method of copper ions

Examples

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Example Embodiment

[0062] Example 1

[0063] Select the gold nanorod solution synthesized by the commonly used seed method, add cetyltrimethylammonium bromide to the concentration of 0.3, 0.5, 0.8, 1mM after purification, respectively, take 1.0mL, and add 7.5μL of 20mM sodium citrate to it , Mix uniformly; put it in a constant temperature water bath at 27°C; measure the extinction spectrum of the mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and measure the temperature at 27°C.

[0064] The result of extinction spectrum changing with time is as follows figure 2 As shown, it shows the influence of the concentration of the surfactant cetyltrimethylammonium bromide on the side-by-side assembly of gold nanorods in the method of the present invention. When the concentration of the surfactant is low, the assembly is too fast and will cause chaotic assembly. ; When the surfactant concentration is high, the reaction is too slow, and the side-by-side assembly of gold nano...

Example Embodiment

[0065] Example 2

[0066] Select the gold nanorod solution synthesized by the commonly used seed method, add cetyltrimethylammonium bromide to a concentration of 0.5mM after purification, take 1.0mL, and add 0.1, 0.15, 0.3, 0.5, 1mM sodium citrate to it , Mix uniformly; put it in a constant temperature water bath at 27°C; measure the extinction spectrum of the mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and measure the temperature at 27°C.

[0067] The result of extinction spectrum changing with time is as follows image 3 As shown, it shows the influence of sodium citrate concentration on the side-by-side assembly of gold nanorods in the method of the present invention. When the sodium citrate concentration is low, the assembly speed is slow; when the sodium citrate concentration is high, the reaction is too fast. It is easy to form chaotic assembly of gold nanorods in a short time. Based on this, the present invention can adjust the speed o...

Example Embodiment

[0068] Example 3

[0069] Select the gold nanorod solution synthesized by the commonly used seed method, take 1.0mL gold nanorods with concentrations of 0.025, 0.05, 0.1, 0.15nM, and add cetyltrimethylammonium bromide to a concentration of 0.5mM after purification. Add 0.15mM sodium citrate to it and mix well; put it in a constant temperature water bath at 27°C; measure the extinction spectrum of the mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and the temperature is 27°C.

[0070] The result of extinction spectrum changing with time is as follows Figure 4 As shown, it shows the influence of the concentration of gold nanorods in the side-by-side assembly in the method of the present invention. When the concentration of gold nanorods is low, the assembly speed is faster, and chaotic assembly of gold nanorods is formed in a short time; When the concentration of nanorods is high, the reaction rate is moderate, and it is easy to form a good gold n...

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Abstract

The invention relates to a chirality assembling structure construction method formed by a gold nanorod side-by-side assembly and sulfydryl-containing chiral molecule and a method for detecting copper ions with high sensitivity by using Plasmon circular dichroism signal. After adding the sulfydryl-containing chiral molecule in the nanorod side-by-side assembly, the chiral molecule is adsorbed on the gold nanorod rod surface by forming gold-sulphur bond to twist the gold nanorod rod and form PCD signals. Copper ions can catalyze and dissolve oxygen and oxidize the sulfydryl-containing chiral molecule to form disulphide; as the latter is weak in adsorption on the gold nanorod rod, the chiral assembly PCD signals are changed. By utilizing the principle, the pmol-magnitude copper ions are measured by establishing the relationship between the copper ions to be tested and the chiral assembly structure PCD signals.

Description

technical field [0001] The invention relates to a method for constructing a chiral structure of gold nanorods and a method for detecting copper ions, in particular to an ultrasensitive detection method for copper ions based on the surface plasmon circular dichroism signal of gold nanorods assembled side by side. Background technique [0002] In 2009, Kotov et al. (Chen, W.; Bian, A.; Agarwal, A.; Liu, L.; Shen, H.; Wang, L.; Xu, C.; Kotov, N.A., Nanoparticle superstructures made by polymerase chain reaction: collective interactions of nanoparticles and a new principle for chiral materials. Nano letters 2009, 9, 2153-2159.) Tetrahedral assembly of spherical gold nanoparticles was obtained by using polymerase chain reaction (Polymerase Chain Reaction, PCR) body, and discovered the plasmonic circle dichroism (Plasmonic Circle Dichroism, PCD) phenomenon of the assembly. Following the pioneering work of Kotov et al., the phenomenon of PCD of complexes and assemblies of noble met...

Claims

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Application Information

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IPC IPC(8): G01N21/19
CPCG01N21/19G01N21/554
Inventor 温涛侯帅张会颜娇吴晓春
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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