Composite bioceramic material and preparation method thereof

A technology of composite bioceramics and ceramics, used in medical science, prosthesis and other directions, can solve the problems of low strength, changes in surrounding biological tissues, toxic metal ions in the human body, etc., and achieve the effect of good mechanical properties and good biocompatibility

Inactive Publication Date: 2018-01-19
WUXI SHENGYA BIOTECH CO LTD FOSHAN BRANCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the past, the most widely used biomedical materials were metal and organic materials, but they had many disadvantages. For example, after metal materials are implanted into the human body, they are prone to corrosion, produce metal ions that ...

Method used

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  • Composite bioceramic material and preparation method thereof
  • Composite bioceramic material and preparation method thereof

Examples

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Effect test

Embodiment 1

[0016] A composite bioceramic material, prepared from the following components in parts by weight: 20 parts of porous hydroxyapatite, 10 parts of biphasic calcium phosphate ceramics, 5 parts of octacalcium phosphate, 1 part of calcium pyrophosphate, 2 parts of polylactic acid, 1 part of phenolic epoxy resin, 0.6 parts of calcium nitrate, 1 part of ramie seed gum, 0.3 parts of carbon spheres, 0.2 parts of chitosan, 0.4 parts of nano-zinc oxide, 1 part of polyoxyethylene-polyoxypropylene copolymer, 0.5 parts of nano-titanium dioxide 0.4 parts of strontium carbonate, 1 part of polyoxyethylene polyoxypropylene pentaerythritol ether, 2 parts of 3,3'-diaminodipropylamine, 2 parts of polyethylene glycol, and 80 parts of distilled water.

[0017] The preparation method of the composite bioceramic material is as follows: S1: Porous hydroxyapatite, biphasic calcium phosphate ceramics, octacalcium phosphate, calcium pyrophosphate, calcium nitrate, ramie seed gum, carbon spheres, nano-tita...

Embodiment 2

[0019] A composite bioceramic material, prepared from the following components in parts by weight: 22 parts of porous hydroxyapatite, 12 parts of biphasic calcium phosphate ceramics, 6 parts of octacalcium phosphate, 1.2 parts of calcium pyrophosphate, 2.5 parts of polylactic acid, 1.5 parts of phenolic epoxy resin, 0.7 parts of calcium nitrate, 1-2 parts of ramie seed gum, 0.4 parts of carbon balls, 0.24 parts of chitosan, 0.5 parts of nano-zinc oxide, 1.2 parts of polyoxyethylene-polyoxypropylene copolymer, nano 0.6 parts of titanium dioxide, 0.48 parts of strontium carbonate, 1.2 parts of polyoxyethylene polyoxypropylene pentaerythritol ether, 2.5 parts of 3,3'-diaminodipropylamine, 2.8 parts of polyethylene glycol, and 90 parts of distilled water.

[0020] The preparation method of the composite bioceramic material is as follows: S1: Porous hydroxyapatite, biphasic calcium phosphate ceramics, octacalcium phosphate, calcium pyrophosphate, calcium nitrate, ramie seed gum, car...

Embodiment 3

[0022] A composite bioceramic material, prepared from the following components in parts by weight: 25 parts of porous hydroxyapatite, 15 parts of biphasic calcium phosphate ceramics, 7.5 parts of octacalcium phosphate, 1.5 parts of calcium pyrophosphate, 3 parts of polylactic acid, 2 parts of phenolic epoxy resin, 0.9 parts of calcium nitrate, 1.7 parts of ramie seed gum, 0.5 parts of carbon spheres, 0.3 parts of chitosan, 0.6 parts of nano-zinc oxide, 1.4 parts of polyoxyethylene-polyoxypropylene copolymer, 0.8 parts of nano-titanium dioxide 0.6 parts of strontium carbonate, 1.6 parts of polyoxyethylene polyoxypropylene pentaerythritol ether, 4 parts of 3,3'-diaminodipropylamine, 3.5 parts of polyethylene glycol, and 130 parts of distilled water.

[0023] The preparation method of the composite bioceramic material is as follows: S1: Porous hydroxyapatite, biphasic calcium phosphate ceramics, octacalcium phosphate, calcium pyrophosphate, calcium nitrate, ramie seed gum, carbon ...

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Abstract

The invention provides a composite bioceramic material and a preparation method thereof. The preparation method comprises the steps as follows: S1, porous hydroxyapatite, two-phase calcium phosphate ceramic, octacalcium phosphate, calcium pyrophosphate, calcium nitrate, ramie seed gum, carbon spheres, nano titania, chitosan, nano zinc oxide, strontium carbonate and distilled water are mixed, and the mixture is ball-milled in a planetary ball mill; S2, polylactic acid, phenolic epoxy resin and 3,3'-diaminodipropylamine are added, and the mixture is stirred at the rotating speed of 100-200 r/min; S3, a polyoxyethylene-polyoxypropylene copolymer, polyoxyethylene-polyoxypropylene pentaerythrilol ether and polyethylene glycol are added, and the mixture is stirred and then placed in a vacuum drying oven to be vacuumized for defoaming treatment; S4, the obtained mixture is poured in a freeze casting device and a frozen green body is obtained; S5, the green body is placed in a sintering furnace to be sintered for 3-4 h after being freeze-dried, and the composite bioceramic material is obtained. The composite bioceramic material has very good biocompatibility and good mechanical performance.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a composite bioceramic material and a preparation method thereof. Background technique [0002] With the development of material science, biomaterials have become an important part of today's biomedical engineering because of their special functions of repairing, replacing and regenerating body tissues. In the past, the most widely used biomedical materials were metal and organic materials, but they had many disadvantages. For example, after metal materials are implanted into the human body, they are prone to corrosion, produce metal ions that are toxic to the human body, and metal wear debris will cause surrounding Changes in biological tissues and other issues; while organic materials are mostly low in strength, and it is difficult to meet the requirements of mechanical properties and durability. Bioceramics generally refers to ceramic materials related to living organisms or bioch...

Claims

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Application Information

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IPC IPC(8): C04B35/447C04B35/622A61L27/40
Inventor 庞婉青
Owner WUXI SHENGYA BIOTECH CO LTD FOSHAN BRANCH
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