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Preparation method and application of compound ketoconazole ointment

A technology of compound ketoconazole and ointment, which is applied in the field of preparation of compound ketoconazole ointment, can solve problems such as difficult treatment, difficult to achieve radical cure, and serious drug resistance, so as to improve the treatment effect, improve itching and discomfort, and improve stability sexual effect

Active Publication Date: 2018-01-26
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At the same time, pet fungal skin diseases are prone to repeated infections, serious drug resistance, and difficult to treat
However, the existing drugs on the market have general therapeutic effects on pet fungal skin diseases, and it is difficult to achieve a radical cure.
At the same time, although the existing medicines have done a lot of research on the compound use of medicines, there are few in-depth researches on the preparation methods of medicines for the treatment of pet skin diseases.

Method used

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  • Preparation method and application of compound ketoconazole ointment
  • Preparation method and application of compound ketoconazole ointment
  • Preparation method and application of compound ketoconazole ointment

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preparation example Construction

[0036] The preparation method of compound ketoconazole ointment of the present invention can preferably refer to as follows:

[0037] (a) Mix and heat the oil phase raw materials to 60-70°C, after the raw materials are completely dissolved, stir evenly to obtain the oil phase mixed system, and preferably keep it warm at the heating temperature;

[0038] (b) adding anhydrous sodium sulfate into water to dissolve completely;

[0039] (c) adding metronidazole into water heated to 70-85°C, stirring and dissolving completely, and preferably keeping warm at the dissolution temperature;

[0040] (d) After heating dilute hydrochloric acid to 60-70°C, add ketoconazole and stir to dissolve completely, and preferably keep warm at the dissolution temperature;

[0041] (e) Add the solution obtained in steps (b), (c) and (d) into the oil phase mixing system, stir and mix, add menthol after cooling, stir and mix evenly, and obtain a viscous paste, which is the compound ketoconazole ointment...

Embodiment 1

[0073] According to mass percentage, sodium lauryl sulfate 3%, glyceryl monostearate 3%, stearyl alcohol 5%, vaseline 5%, liquid paraffin 3%, vitamin E oil 2%, isopropyl myristate 2% %, 1% of anhydrous sodium sulfite, 1% of ketoconazole, 2% of metronidazole, 1% of menthol, 5% of 0.1M dilute hydrochloric acid, and the rest of water, respectively weighing appropriate amounts of each raw material;

[0074] (a) Glyceryl monostearate, stearyl alcohol, vaseline, liquid paraffin, vitamin E oil, and isopropyl myristate are mixed and heated to 65°C. After the raw materials are completely dissolved, stir evenly and keep warm at 65°C to obtain Oil phase mixed system;

[0075] (b) adding anhydrous sodium sulfate to 10% recipe volume water and dissolving completely;

[0076] (c) Add sodium lauryl sulfate to the remaining prescription water heated to 80°C and stir to dissolve, then add metronidazole and stir to dissolve completely, and keep warm at 80°C;

[0077] (d) After heating dilute ...

Embodiment 2

[0080] According to mass percentage, Tween-80 3%, Span-80 2%, glyceryl monostearate 2%, stearyl alcohol 2%, vaseline 2%, liquid paraffin 5%, vitamin E oil 5%, nutmeg 3% of isopropyl ester, 1% of anhydrous sodium sulfite, 1% of ketoconazole, 2% of metronidazole, 1% of menthol, 5% of 0.1M dilute hydrochloric acid, and the rest of water, respectively weighing appropriate amount of each raw material;

[0081] (a) Mix Tween-80, Span-80, glyceryl monostearate, stearyl alcohol, petrolatum, liquid paraffin, vitamin E oil, and isopropyl myristate and heat to 65°C. After the raw materials are completely dissolved , stir evenly to obtain an oil phase mixed system, and keep it warm at 65°C;

[0082] (b) Anhydrous sodium sulfate is added to dissolve completely in the water of 10% recipe quantity;

[0083] (c) Metronidazole is added to the remaining prescription water heated to 80°C, stirred and dissolved completely, and kept at 80°C;

[0084] (d) After heating dilute hydrochloric acid to...

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Abstract

The invention provides a preparation method and application of compound ketoconazole ointment. The preparation method utilizes medicinal effective components such as ketoconazole, metronidazole and menthol and aids such as anhydrous sodium sulfite, a surfactant and hydrochloric acid as raw materials. Through adjustment and optimization of the preparation method, the compound ketoconazole ointmenthas stable performances and good bactericidal performances, effectively treats pet skin diseases and can be further used in preparation of a drug containing ketoconazole or metronidazole.

Description

technical field [0001] The invention relates to the field of antifungal drugs for pets, in particular to a preparation method and application of compound ketoconazole ointment. Background technique [0002] The pet market is developing rapidly. According to a survey by the American Pet Products Association, in 2005, the pet industry in the United States spent more than 36 billion U.S. dollars, which nearly doubled to more than 60 billion U.S. dollars in 2015. [0003] While pets bring a lot of happiness to every family, skin diseases cause people a lot of troubles. On the one hand, they are afraid that skin diseases will be transmitted to people; The loss of appetite made the owner very heartbroken. Dermatosis is a kind of disease that seriously endangers the health of pet dogs. There are many types, and its etiology is also complex and diverse. Among them, parasitic and fungal skin diseases are the most frequent. [0004] Fungal dermatosis is caused by various fungi infec...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K31/496A61K31/045A61K9/06A61P31/10A61P17/00A61P29/00A61P17/04
Inventor 寇贺红陶映娴赵奉君马静蓉付良凯
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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