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Norfloxacin capsule and preparation method thereof

A technology of norfloxacin and capsules, applied in the field of norfloxacin capsules and its preparation

Inactive Publication Date: 2018-01-30
合肥远志医药科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing capsule excipients are prone to react with norfloxacin

Method used

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  • Norfloxacin capsule and preparation method thereof
  • Norfloxacin capsule and preparation method thereof
  • Norfloxacin capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Formula

[0018]

[0019] Preparation method: After the raw and auxiliary materials have been sieved, weigh norfloxacin, starch, dextrin, and low-substituted-hypromellose respectively according to the formula requirements, and add hypromellose solution to them to make soft materials. YK-160 Oscillating Granulator Standard Operating Procedure (SOP-P-2319) to operate, the soft material is made into wet granules through the oscillating granulator with a 20-mesh nylon screen, and the wet granules are transferred to the through-flow oven. "CTG-Z-II Through-flow Oven Standard Operating Procedures" (SOP-P-2079) to operate, the drying temperature is 60 ° C, the particles are dried for 2 hours, taken out, sized with a 24-mesh sieve, added with silicon dioxide and mixed.

Embodiment 2

[0021] 1. Formula

[0022]

[0023] Second, the method

[0024] Preparation method: After the raw and auxiliary materials have been sieved, weigh norfloxacin, starch, dextrin, and low-substituted-hypromellose respectively according to the formula requirements, and add hypromellose solution to them to make soft materials. YK-160 Oscillating Granulator Standard Operating Procedure (SOP-P-2319) to operate, the soft material is made into wet granules through the oscillating granulator with a 20-mesh nylon screen, and the wet granules are transferred to the through-flow oven. "CTG-Z-II Through-flow Oven Standard Operating Procedures" (SOP-P-2079) to operate, the drying temperature is 60 ° C, the particles are dried for 2 hours, taken out, sized with a 24-mesh sieve, added with silicon dioxide and mixed.

Embodiment 3

[0026] 1. Formula

[0027]

[0028]

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PUM

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Abstract

The invention discloses a norfloxacin capsule and a preparation method thereof. The norfloxacin capsule is prepared from, by weight, 10-20 parts of ambroxol hydrochloride, 20-80 parts of lactose, 10-60 parts of corn starch, 1-2 parts of silicon dioxide and 0.5-1 part of magnesium stearate. An ambroxol hydrochloride table composition obtained is controllable in quality and has the advantages of quick dissolution as compared with domestic market-selling tablets and the similarity in dissolution with a reference preparation.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. Specifically, the present invention relates to a norfloxacin capsule and a preparation method thereof. Background technique [0002] The chemical name of norfloxacin is 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid, and this product is the second Substitute quinolone antibacterial drugs can hinder the DNA helicase of pathogenic bacteria in the digestive tract, hinder bacterial DNA replication, and have an inhibitory effect on bacteria. They are commonly used drugs for the treatment of enteritis, dysentery and urinary tract infections. This drug has a delaying effect on the bone formation of minors and will affect development, so it is forbidden for minors to take it. Existing capsule excipients are prone to react with norfloxacin. Its chemical formula structural formula is: [0003] Contents of the invention [0004] The object of the present i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/496A61K47/38A61P31/04A61P1/12A61P13/04
Inventor 金慧芳
Owner 合肥远志医药科技开发有限公司
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