Mesoporous silica nano-drug carrier and preparation method thereof

A nano drug carrier, mesoporous silica technology, applied in the field of materials and pharmaceuticals, inorganic chemistry, can solve the problem of difficult biodegradation of mesoporous silica, achieve good structural stability, improve biodegradability, and benefit Effects of degradation and excretion

Inactive Publication Date: 2018-02-13
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a mesoporous silica nano drug carrier and its preparation method, which solves the problem that mesoporous silica is difficult to biodegrade

Method used

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  • Mesoporous silica nano-drug carrier and preparation method thereof
  • Mesoporous silica nano-drug carrier and preparation method thereof
  • Mesoporous silica nano-drug carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The mesoporous silica nano-drug carrier in this example is composed of calcium phosphate and silicon dioxide with a mass ratio of 1:18.5.

[0029] Preparation of Mesoporous Silica Nano-Drug Carriers:

[0030] Dissolve 0.118g of disodium hydrogen phosphate in a mixed solvent of 25mL of distilled water + 8.75mL of ammonia water + 90mL of ethanol, then add 0.047g of octadecyltrimethoxysilane, stir and mix well, then add 0.055g of ethyl orthosilicate, Next, 0.055 g of calcium chloride was added under stirring conditions, and then the entire mixed solution was stirred and reacted at 30° C. for 8 hours. After the reaction was completed, suction filtration and washing were performed to obtain calcium phosphate-doped silica nanoparticles.

[0031] Calcium phosphate-doped silica nanoparticles were dried at 40° C. for 6 hours, and then sintered at 550° C. for 6 hours to obtain mesoporous silica nanometer drug carriers.

[0032] Structural characterization of mesoporous silica na...

Embodiment 2

[0042] The mesoporous silica nano-drug carrier in this example is composed of calcium phosphate and silicon dioxide with a mass ratio of 1:2.42.

[0043] Preparation of Mesoporous Silica Nano-Drug Carriers:

[0044] Dissolve 0.118g of disodium hydrogen phosphate in a mixed solvent of 100mL of distilled water + 8mL of ammonia water + 140mL of ethanol, then add 0.011g of octadecyltrimethoxysilane, stir and mix well, then add 0.042g of ethyl orthosilicate, then Add 0.177g of calcium chloride under stirring condition, then stir the whole mixed solution at 30°C for 8h, after the reaction is completed, suction filter and wash to obtain calcium phosphate doped silica nanoparticles.

[0045] Calcium phosphate-doped silica nanoparticles were dried at 30° C. for 12 hours, and then sintered at 700° C. for 5 hours to obtain mesoporous silica nanometer drug carriers.

[0046] The average particle diameter of the prepared mesoporous silica nano drug carrier is 25nm, and the average pore di...

Embodiment 3

[0048] In this example, the mesoporous silica nano drug carrier is composed of calcium phosphate and silica, and the mass ratio thereof is 1:25.8.

[0049] Preparation of Mesoporous Silica Nano-Drug Carriers:

[0050] Dissolve 0.118g of disodium hydrogen phosphate in a mixed solvent of 35mL of distilled water + 13mL of ammonia water + 80mL of ethanol, then add 1.084g of octadecyltrimethoxysilane, stir and mix well, then add 4.308g of ethyl orthosilicate, then Add 0.184g of calcium chloride under stirring condition, then stir the whole mixed solution at 30°C for 8h, after the reaction is completed, suction filter and wash to obtain calcium phosphate doped silica nanoparticles.

[0051] Calcium phosphate-doped silica nanoparticles were dried at 70° C. for 4 hours, and then sintered at 500° C. for 7 hours to obtain mesoporous silica nanometer drug carriers.

[0052] The average particle diameter of the prepared mesoporous silica nano drug carrier is 50nm, and the average pore di...

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Abstract

The invention discloses a mesoporous silica nano-drug carrier and a preparation method thereof. The mesoporous silica nano-drug carrier mainly comprises calcium phosphate and silicon dioxide of whichthe mass percent ratio is 1-1.2 to 2.9-25.8. As calcium phosphate is doped with a mesoporous silica skeleton, the -Si-O-Si-bond density is reduced, and the biodegradability of mesoporous silica is improved; besides, the characteristic that calcium phosphate is stable under a neutral condition and easily soluble under an acid condition is utilized, so that drug release has the pH response characteristic, and drug targeted therapy is realized; on the other hand, dissolution of calcium phosphate enables pyrolysis of silica carrier, and degradation and excretion of the carrier are more facilitated.

Description

technical field [0001] The invention belongs to the technical field of inorganic chemistry, materials and medicaments, and in particular relates to a mesoporous silica nano drug carrier and a preparation method thereof. technical background [0002] As an inorganic drug carrier material, mesoporous silica nanomaterials have a large specific surface area and high porosity, can absorb more drug molecules in the channels, encapsulate the drugs in the mesoporous channels, and reduce the The loss of the drug during the delivery process in the body reduces the toxic and side effects of the drug on normal tissue cells, and the pore structure plays a role in the slow release of the drug, which can prolong the action time of the drug. [0003] Mesoporous silica has no physiological toxicity and good biocompatibility, but due to its rigid structure and chemical inertness, it is difficult to degrade in the biological environment. Studies have shown that it is difficult to degrade in bu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K47/04C01B25/32C01B33/12A61K31/704A61P35/00
CPCA61K9/0002A61K9/143A61K31/704C01B25/325C01B33/12C01P2002/82C01P2002/85C01P2004/03C01P2004/04C01P2004/64C01P2006/16
Inventor 何勇菊龙孟秋徐慧李明君李新梅吴迪杨开魏
Owner CENT SOUTH UNIV
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