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Nitraria fruit active extract preparation method and application

A technology of extract and Nitraria fruit, which is applied in the field of preparation of Nitraria fruit active extract, can solve the problems of cumbersome steps, explosiveness, toxicity, etc., and achieve the effect of mild extraction conditions, large extraction volume and high yield

Inactive Publication Date: 2018-02-13
BEIJING BOXIN NATURE BIOTECH LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some patents have disclosed the extraction methods of red pigment and polyphenols in Nitraria fruit and Nitraria bark, the process involves solvent extraction, microwave, ultrasonic-assisted extraction, resin adsorption purification, membrane separation, etc., and the steps are cumbersome. Time-consuming and labor-intensive, many kinds of chemical solvents are used. Some solvents are not only unsafe to operate, toxic and explosive, but also listed as prohibited foods that are toxic to the human body.
Moreover, it has adverse effects on the taste of the product, etc.
Although there is subsequent drying, it is difficult to guarantee that there is no residue
The extraction method with solvent is non-green, and the subsequent solvent removal process uses high temperature, which will destroy the functional nutrients
And the vast majority of patents do not mention the content and extraction rate of target components
[0004] In addition, studies have shown that after repeated purification and extraction of functional components of natural plants, although the concentration of monomer components has increased, their functional activity has actually decreased.

Method used

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  • Nitraria fruit active extract preparation method and application
  • Nitraria fruit active extract preparation method and application
  • Nitraria fruit active extract preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] supercritical extraction

[0062] Supercritical fluid (supercritical fluid, SF) refers to a certain gas (liquid) or gas (liquid) mixture when the operating pressure and temperature are higher than the critical point, making its density close to liquid, while its diffusion coefficient and viscosity are close to gas , a fluid whose properties are between that of a gas and a liquid. Supercritical fluid extraction (SFE) technology is a technology that uses supercritical fluid as a solvent to extract certain effective components from solid or liquid and separate them. Carbon dioxide-supercritical fluid extraction is more suitable for the extraction of lipophilic, relatively small molecular weight substances. Here, the carbon dioxide-supercritical fluid extraction method is suitable for extracting the oil components in Nitraria.

[0063] (1) obtain the white thorn fruit raw material;

[0064] The Nitraria raw material comprises Nitraria fresh fruit, Nitraria dried fruit, N...

Embodiment 2

[0116] solvent extraction

[0117] The solvent extraction method has simple steps, can be extracted in large quantities, and is easy to carry out large-scale production and application in industry.

[0118] (1) obtain the white thorn fruit raw material;

[0119] The used Nitraria raw material of solvent extraction method is identical with the used Nitraria raw material of the supercritical extraction method in the last embodiment,

[0120] (2) In the extraction equipment, the raw material of Nitraria japonica and 65% ethanol are stirred and extracted at a temperature of -55°C;

[0121] In order to achieve a better extraction effect, at least one of the following extraction conditions can also be optimized:

[0122] (2.1) Adjust the mass volume ratio of Nitraria japonica raw material and 65% ethanol, preferably any value in 1:3~5;

[0123] (2.2) Select an appropriate stirring and extraction time, preferably 1 to 2 hours for extraction;

[0124] (2.3) Perform repeated extrac...

Embodiment 3

[0140] Comparison of the Yield and Content of Active Components in Nitraria

[0141] Based on the supercritical extraction method described in Example 1, the active extract of Nitraria japonica raw materials was extracted one by one according to the conditions shown in Table 8, and the corresponding yield, red pigment content and total polyphenol content were obtained.

[0142] The results show that in the range of better extraction conditions, when the degreasing raffinate with higher oil removal degree is extracted again, the product yield, red pigment content and total polyphenol content are all higher; In addition, increasing the static soaking time and prolonging the dynamic extraction time also help to increase the yield and the total polyphenol content, but the effects of these two methods on the increase of the red pigment content are not obvious.

[0143] The comparison of productive rate, red pigment content and total polyphenol content under each condition of table ...

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Abstract

The invention discloses a nitraria fruit active extract preparation method which comprises a supercritical extraction process and a solvent extraction purification process. The invention further discloses pharmaceutical composition, health-care preparation and nitraria fruit active extract prepared by the nitraria fruit active extract preparation method. The nitraria fruit active extract preparation method disclosed by the invention has the advantages of moderate condition, high extraction efficiency and good extract activity retention; the obtained extract has a good medicine health care popularizing prospect.

Description

technical field [0001] The invention relates to a preparation technology of plant active extracts, in particular to a preparation method of active extracts of Nitraria japonica and uses of the active extracts of Nitraria japonica. Background technique [0002] Tangut Nitraria grows in the Qaidam Basin, the highest altitude among the eight deserts in my country, and is recognized as the "purest" place in the world. The high altitude, strong ultraviolet rays and hypoxic environment have created the pure natural and pollution-free raw material quality of Nitraria. Nitraria fruit is a rare wild fruit. The mature Nitraria fruit is crystal clear, red like pearls and purple like agate, so it is called "Plateau Red Pearl". There are many kinds of nutritional components and medical and health active components in its fruit, and the content is rich. The local people use it to strengthen the spleen and stomach, help digestion, soothe the nerves, relieve the surface, and breast milk. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/489A61P13/08A61P13/02A61P27/02A61P37/02A61K31/01
CPCA61K31/01A61K36/489A61K2236/51A61K2236/55A61K2236/39A61K2236/37A61K2236/333A61K2300/00A61P43/00A61K2236/00A23L33/105A61K36/185A61P15/10A61P27/02A61P7/02A61P9/12A61P13/02A61P35/00A61K31/4985A61P13/08A23V2002/00A23V2200/308A23V2200/326A23V2250/213A61K2236/15
Inventor 靳青唐韶坤贾维尔·安古拉
Owner BEIJING BOXIN NATURE BIOTECH LTD
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