Scar removing composition and preparation method thereof

A composition and scar removal technology, applied in the directions of drug combinations, active ingredients of hydroxyl compounds, pharmaceutical formulations, etc., can solve problems such as the inability to meet the needs of the market, and achieve the effects of eliminating various scars, reducing pigment deposition, and promoting degradation.

Active Publication Date: 2018-02-16
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although various products developed for scar removal have emerged in an endless stream in recent years, there are still relatively few products with significant curative effect, high safety, convenient use and industrial production, which cannot meet the needs of the market.

Method used

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  • Scar removing composition and preparation method thereof
  • Scar removing composition and preparation method thereof
  • Scar removing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 composite bioactive factor nano liposome

[0027]

[0028]

[0029] The preparation of the complex bioactive factor nanoliposome described in group A of the present invention comprises the following steps:

[0030] (1) Weigh 0.2g of phosphatidylcholine, 0.08g of cholesterol, and 0.04g of distearoylphosphatidylethanolamine, mix them, dissolve in 50mL of ethanol, and sonicate for 5min;

[0031] (2) Rotate evaporation at 28°C and 0.1MPa to remove ethanol, let it stand for 30min, add 100mL pH of 7.4 phosphate buffer solution containing 0.5% (m / v) complex biologically active factors, and place in a water bath at 35°C Medium shaking hydration reaction for about 1 hour to obtain liposome suspension;

[0032] (3) Use a syringe filter to adjust the particle size of the liposome suspension to 150nm to obtain nanoliposomes of complex bioactive factors.

[0033] For the preparation of complex biologically active factor nanoliposomes in groups...

Embodiment 2-4 and comparative example 1-4

[0034] Preparation of Example 2-4 and Comparative Example 1-4 Composition for Dispelling Scars

[0035] The composition of embodiment 2-4 of the present invention and comparative example 1-4 scar removal composition is shown in the table below:

[0036]

[0037]

Embodiment 2

[0038] The preparation of embodiment 2 scar removal compositions:

[0039] Dissolve polyvinylpyrrolidone K30 in distilled water, add glycerin and 1,2-propanediol, and stir evenly to make a matrix; add lipoic acid, hexamerpeptide, minetal peptide, plumbagin, and inositol in sequence, stir well, and finally Add composite bioactive factor nanoliposome and imidazolidinyl urea, vortex for 4 minutes, and obtain.

[0040] For the preparation of the scar-removing compositions of Examples 3 and 4 and Comparative Examples 1-4, refer to the above-mentioned method.

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Abstract

The invention relates to a scar removing composition, which comprises the following components in percentage by weight: 2 to 8% of hexa-peptide, 2 to 8% of five mineral peptide, 1 to 4% of thioctic acid, 0.05 to 1% of plumbagin, 1 to 4% of inositol, 2 to 6% of composite nano liposome with biological activity, and 70 to 80% of antiseptic with m/v of 0.01-1.0% and auxiliary materials. The provided scar removing composition can prominently enhance the activity of matrix metalloproteinase, the degradation of accumulated I type collagen is promoted; the expression of fibronectin is obviously reduced; the density of fibroblast is reduced, the generation of scars is decelerated, the proliferative index of scar is decreased; the scar removing effect is good, at the same time, the clinical data shows that the scar removing composition also has a good effect for patients of hyper-plastic scars, and the cure rate can reach 96.7%.

Description

technical field [0001] The invention relates to the technical field of scar repair, in particular to a scar removing composition and a preparation method thereof. Background technique [0002] Scar is a hyperplastic lesion caused by trauma. Its tissue is formed by collagen fibers and matrix, fibroblasts and local mucopolysaccharide deposition. The formation process includes different stages such as inflammation, cell migration / proliferation and deposition of extracellular matrix. The clinical manifestations are damaged skin shape and different degrees of dysfunction. According to the different causes and symptoms of scar formation, it can be divided into superficial scars, hypertrophic scars, atrophic scars, contracture scars, depressed scars, painful scars, and keloids. At present, the mechanism of scar formation is not yet fully understood. It is generally believed that the massive proliferation and apoptosis of fibroblasts in wound repair, the unbalanced synthesis and de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/19A61K9/127A61P17/02A61K38/08A61K38/18A61K31/385A61K31/122A61K31/047
CPCA61K9/127A61K31/047A61K31/122A61K31/385A61K38/08A61K38/18A61K38/193A61K2300/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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