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Preparation method, product and application of antibacterial bone promoting composite coating on surface of PET fiber

A composite coating, fiber surface technology, used in coatings, medical science, prostheses, etc., can solve problems such as poor hydrophilicity and poor osteoconductivity, and achieve high biosafety, good biocompatibility, The method is simple and effective

Inactive Publication Date: 2018-03-06
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the disadvantages of poor hydrophilicity and poor osteoconductivity of PET materials, the object of the present invention is to provide a preparation method of an antibacterial and bone-promoting composite coating on the surface of PET fibers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The PET fiber material was soaked in absolute ethanol, and ultrasonically treated for 30 min to remove the impurities adhered to the surface of the material. After the material was taken out, it was repeatedly washed with a large amount of ultrapure water to remove residual ethanol, and dried at room temperature. A 5 wt% sodium hydroxide solution was prepared, the PET material was soaked in it, and boiled for 1 h. The material was repeatedly washed with a large amount of ultrapure water until the pH value was about 7, and then dried at 60 °C to obtain a PET fiber material with a carboxyl-terminated end group.

[0028] Soak the above-treated PET material in 0.2 M morpholineethanesulfonic acid (MES) buffer solution with pH=5.5 for 2 h, and then add 0.2 M 1-ethyl-3-(3-dimethylaminopropyl ) carbodiimide hydrochloride (EDC) and 10 mM N-hydroxysuccinimide (NHS), stirred and activated at room temperature for 3 h. Dilute acetic acid with ultra-pure water to a dilute acetic ac...

Embodiment 2

[0031] The PET fiber material was soaked in absolute ethanol, and ultrasonically treated for 30 min to remove the impurities adhered to the surface of the material. After the material was taken out, it was repeatedly washed with a large amount of ultrapure water to remove residual ethanol, and dried at room temperature. A 5 wt% sodium hydroxide solution was prepared, the PET material was soaked in it, and boiled for 1 h. The material was repeatedly washed with a large amount of ultrapure water until the pH value was about 7, and then dried at 60 °C to obtain a PET fiber material with a carboxyl-terminated end group.

[0032] Soak the above-treated PET material in 0.2 M morpholineethanesulfonic acid (MES) buffer solution with pH=5.5 for 2 h, and then add 0.2 M 1-ethyl-3-(3-dimethylaminopropyl ) carbodiimide hydrochloride (EDC) and 10 mM N-hydroxysuccinimide (NHS), stirred and activated at room temperature for 3 h. Dilute acetic acid with ultra-pure water to a dilute acetic ac...

Embodiment 3

[0035] The PET fiber material was soaked in absolute ethanol, and ultrasonically treated for 30 min to remove the impurities adhered to the surface of the material. After the material was taken out, it was repeatedly washed with a large amount of ultrapure water to remove residual ethanol, and dried at room temperature. A 5 wt% sodium hydroxide solution was prepared, the PET material was soaked in it, and boiled for 1 h. The material was repeatedly washed with a large amount of ultrapure water until the pH value was about 7, and then dried at 60 °C to obtain a PET fiber material with a carboxyl-terminated end group.

[0036] Soak the above-treated PET material in 0.2 M morpholineethanesulfonic acid (MES) buffer solution with pH=5.5 for 2 h, and then add 0.2 M 1-ethyl-3-(3-dimethylaminopropyl ) carbodiimide hydrochloride (EDC) and 10 mM N-hydroxysuccinimide (NHS), stirred and activated at room temperature for 3 h. Dilute acetic acid with ultra-pure water to a dilute acetic ac...

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Abstract

The invention relates to a preparation method, a product and application of an antibacterial bone promoting composite coating on the surface of PET fiber. According to the method, the only natural alkaline polysaccharide chitosan and a bone-like inorganic salt namely hydroxyapatite in nature are used as coating materials, and a CTS-HAP composite coating on the surface of PET is prepared by utilizing an EDC / NHS crosslinking method and a simulated body fluid method successively. Different coating materials are prepared by changing a preparation method of a chitosan solution and deposition conditions of hydroxyapatite. The material has good biocompatibility, bioactivity, bone induction and antibacterial performance, the preparation method is simple and feasible, and the product can meet requirements of biomedical application. The used raw materials are high in biological safety, and part of the raw materials are commercial products. The composite coating material prepared with the methodprovided by the invention has the characteristics of good biocompatibility, bioactivity, bone induction, antibacterial performance and the like. The method provided by the invention is simple and feasible, has strong operability, and can further meet requirements of clinical application and large-scale production.

Description

technical field [0001] The invention relates to a method for preparing an antibacterial and bone-promoting composite coating on the surface of a PET fiber and its product and application, in particular to a method for preparing chitosan and a composite coating of chitosan on the surface of a PET fiber material by using the EDC / NHS cross-linking method and the simulated body fluid method sequentially. Hydroxyapatite Coating Method. The invention belongs to the fields of biomedical materials and organic-inorganic composite materials. Background technique [0002] Polyethylene terephthalate (PET) is currently the most clinically used artificial ligament material. PET material itself has poor hydrophilicity and lacks biological activity, which is not conducive to cell adhesion and proliferation; at the same time, its poor osteoconductivity makes it difficult to form a stable osseointegration with autologous bone tissue on the interface, resulting in difficult clinical repair ef...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/34A61L27/32A61L27/50A61L27/54
Inventor 何丹农祝闪闪王萍许国华金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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