Edoxaban sustained-release tablet pharmaceutical composition and preparation method thereof
A technology of edoxaban and sustained-release tablets, which is applied in the field of pharmaceutical preparations, can solve problems such as large fluctuations, strong hygroscopicity, poor fluidity, and difficulty in preparation operations, achieving effective release, good stability, and avoiding large fluctuations Effect
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0020] The preparation of embodiment 1 edoxaban sustained-release tablet
[0021] Prescription ratio:
[0022] Edoxaban 25g
[0023] Hypromellose (60RT10000) 55g
[0024] Hypromellose (SM-1500) 40g
[0025] Lactose 85g
[0026] Povidone K30 12g
[0028] Film coating agent 6g
[0029] Process:
[0030] (1) Sift edoxaban, hypromellose (60RT10000), hypromellose (SM-1500) and lactose, and set aside.
[0031] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.
[0032] (3) Weigh the prescribed amount of edoxaban, hypromellose (60RT10000), hypromellose (SM-1500), and lactose, mix them, add binder to granulate, add the prescribed amount of stearic acid after drying Magnesium mix well.
[0033] (4) Tablets.
[0034] (5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). The plain tablets are placed in a coating pan, sprayed with a film coat, and...
Embodiment 2
[0035] The preparation of embodiment 2 edoxaban sustained-release tablets
[0036] prescription:
[0037] Edoxaban 20g
[0038] Hypromellose (75RT4000) 20 g
[0039] Hypromellose (SM-1500) 12 g
[0040] Lactose 40 g
[0041] Povidone K30 3 g
[0043] Film coating agent 3 g
[0044] Process:
[0045] (1) Sift edoxaban, hypromellose (75RT4000), hypromellose (SM-1500) and lactose, and set aside.
[0046] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.
[0047] (3) Weigh the prescribed amount of edoxaban, hypromellose (75RT4000), hypromellose (SM-1500), and lactose, mix them, add binder to granulate, add the prescribed amount of stearic acid after drying Magnesium mix well.
[0048] (4) Tablets.
[0049] (5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). plain tablet coating
[0050] In the pot, spray the film coat and dry it.
Embodiment 3
[0051] The preparation of embodiment 3 edoxaban sustained-release tablets
[0052] prescription:
[0053] Edoxaban 50g
[0054] Hypromellose (75RT4000) 25 g
[0055] Hypromellose (SM-1500) 25 g
[0056] Lactose 100 g
[0057] Povidone K30 8g
[0058] Magnesium Stearate 3g
[0059] Film coating agent 6g
[0060] Process:
[0061] (1) Sift edoxaban, hypromellose (75RT4000), hypromellose (SM-1500) and lactose, and set aside.
[0062] (2) prepare povidone K30 ethanol solution as adhesive, and set aside.
[0063] (3) Weigh the prescribed amount of edoxaban, hypromellose (75RT4000), hypromellose (SM-1500), and lactose, mix them, add binder to granulate, add the prescribed amount of stearic acid after drying Magnesium mix well.
[0064] (4) Tablets.
[0065] (5) Coating: Take the prescribed amount of colored film coating agent to prepare a coating solution (oxygen barrier, light protection). plain tablet coating
[0066] In the pot, spray the film coat and dry it.
PUM
Property | Measurement | Unit |
---|---|---|
viscosity | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com