A kind of preparation method of pyrrole compound

A compound and mixture technology, applied in the field of preparation of pyrrole compounds, can solve problems such as difficult industrial production and inconvenient implementation
CN107793343BActive Publication Date: 2020-08-07SUNSHINE LAKE PHARM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUNSHINE LAKE PHARM CO LTD
Publication Date
2020-08-07

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Abstract

The invention provides a preparation method of a pyrrole compound and belongs to the technical field of pharmacy. The preparation method comprises that a raw material compound and a halogenation reagent undergo a reaction in an organic solvent to produce a target compound. The halogenation reagent is trimethylchlorosilane, trimethylbromosilane, triethylchlorosilane, tert-butyl dimethylchlorosilane, phenyl dimethylchlorosilane, oxalyl chloride, acetyl chloride, phosphorus oxychloride, phosphorus pentachloride, phosphorus pentabromide, thionyl chloride, sulfuryl chloride or their composition. The preparation method can prevent harsh conditions such as use of hydrogen chloride gas, is carried out under simple reaction conditions, is easy to operate and control and is suitable for industrial production.
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Description

technical field

[0001] The invention relates to a preparation method of pyrrole compound, which belongs to the technical field of pharmacy. Background technique

[0002] Pyrrole compounds are intermediate raw materials in the preparation of various medicines, and are widely used in the preparation of medicines. Such as Vonoprazan (English name Vonoprazan, shown in formula (V)), is a kind of antigastric drug, needs to obtain pyrrole compound earlier in its preparation process, and common method is to use cyano compound as raw material, in hydrochloric acid Under the action of alcohol solution or hydrogen chloride gas, the desired pyrrole compound can be obtained through reaction. This conventional method needs to prepare an alcoholic solution of hydrogen chloride or needs to use hydrogen chloride gas, which is not convenient for industrial implementation and is difficult to be used in industrial production. Therefore, it is necessary to develop a process method that has sim...

Claims

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