Preparation method of artemether

Abstract

The invention discloses a preparation method of artemether, wherein the preparation method mainly includes three steps: step 1), artemisinin hydrogenation; step 2), etherification of dihydroartemisinin; and step 3), crude product purification. Through the three steps, an artemether refined product can be prepared, and the content of beta-artemether is high. The method has the advantages of simpleand practical process, high utilization rate of reaction raw materials, and high purity of the product, and is favorable for industrialized production.

Description

technical field

[0001] The invention relates to a preparation method of artemether, which belongs to the field of pharmaceutical chemical synthesis. Background technique

[0002] Malaria, commonly known as Dabaizi and Dalaozhang, is a global acute parasitic infectious disease caused by Plasmodium, transmitted by Anopheles mosquitoes, and its unique symptoms are intermittent chills and fever. Worldwide, there are between 300 million and 500 million clinical cases each year, and malaria kills between one and three million people each year, most of them children. Children, pregnant women, tourists and new immigrants from all over the world have poor immunity to the locally prevalent malaria parasites, so they are high-risk groups susceptible to malaria. The main endemic areas of malaria are the tropical areas of central Africa, South Asia, Southeast Asia and northern South America, among which the epidemic situation in Africa is the worst.

[0003] Artemether (English name Ar...

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