Biocompatible and thermosensitive nano-composite epoxy resin and preparation method thereof

A biocompatibility and nanocomposite technology, which is applied in the field of biocompatibility and temperature-sensitive nanocomposite epoxy resin and its preparation, can solve the problems of tissue engineering, poor mechanical comprehensive performance, and inconspicuous temperature sensitivity, etc. problem, to achieve the effect suitable for application, low cost and high biocompatibility

Inactive Publication Date: 2018-03-23
成都昂多生物技术有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] From the above analysis, it can be seen that the currently prepared biocompatible epoxy resin has limited raw material sources and no obvious temperature sensitivity; while the general temperature-sensitive epoxy resin has low mechanical properties due to the use of chemical cross-linking agent MBA. Poor; the epoxy resin with high mechanical properties is prepared by using the physical cross-linking agent Clay, but its biocompatibility is poor, so it is difficult to meet the needs of practical applications such as tissue engineering

Method used

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  • Biocompatible and thermosensitive nano-composite epoxy resin and preparation method thereof
  • Biocompatible and thermosensitive nano-composite epoxy resin and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1.20g of isopropylacrylamide, 0.25g of hectorite, 0.05g of polyhydroxybutyrate were added to 10mL of deionized water successively, in a sealed container at 20°C, nitrogen was introduced, ultrasonically dispersed for 30min, and stirred for 45min , until completely dispersed to form a homogeneous solution; the above mixed solution is cooled to 30°C with ice cubes, 0.01g of persulfate is added after 30min, and 20 uL of N,N,N'N'-tetramethylethylenediamine is injected after 10min, Under nitrogen protection, continue to stir for 10 min until the mixed solution begins to appear viscous; immediately pour the viscous mixed solution into a glass mold with a thickness of 2 mm, and stand at 20 °C for in-situ radical polymerization for 24 h. Then, the reaction product was soaked in deionized water for 2 weeks to obtain the biocompatible and temperature-sensitive nanocomposite epoxy resin.

[0040] The obtained nanocomposite epoxy resin: the volume phase transition temperature was 33...

Embodiment 2

[0042] 1.0g isopropylacrylamide, 0.2g lithium magnesium silicate, 0.3g poly(hydroxybutyrate monohydroxyvalerate) were added to 10mL deionized water successively, and in a sealed container at 20°C, nitrogen was introduced. , ultrasonic dispersion for 30min, stirring for 60min, until completely dispersed to form a homogeneous solution; the above mixed solution is cooled to 20C with ice cubes, 0.02g of persulfate is added after 30min, and 40uL of N,N,N'N'-40uL is injected after 10min Methylethylenediamine, under nitrogen protection, continue to stir for 10min, until the mixed solution begins to appear viscous; immediately pour the viscous mixed solution into a glass mold with a thickness of 2mm, and let stand at 25°C for in situ The free radical polymerization reaction is carried out for 20 hours, and then the reaction product is soaked in deionized water for 2 weeks to obtain the biocompatible and temperature-sensitive nanocomposite epoxy resin.

[0043] The obtained nanocomposi...

Embodiment 3

[0045] 1.3g of bisethylacrylamide, 0.15g of hectorite, 0.05g of poly-3-hydroxybutyric acid-3-hydroxycaproate (PI-Il3HHx) were added to 10mL of deionized water successively, and the sealant at 20°C was sealed. In the container, nitrogen was introduced, ultrasonically dispersed for 30min, and stirred for 30min, until completely dispersed to form a homogeneous solution; the above mixed solution was cooled to 3°C with ice cubes, 0.015g of ammonium persulfate was added after 30min, and 301-L N, N was injected after 10min. , N'N'-tetramethylethylenediamine, under nitrogen protection, continue to stir for 10min, until the mixed solution begins to appear viscous; immediately pour the viscous mixed solution into a glass mold with a thickness of 2mm, at 25 The in-situ radical polymerization reaction was carried out by standing at ℃ for 30 hours, and then the reaction product was immersed in deionized water for 2 weeks to obtain the biocompatible and temperature-sensitive nanocomposite ep...

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Abstract

The invention relates to a biocompatible and temperature-sensitive nano-composite epoxy resin and a preparation method thereof. The epoxy resin contains alkacrylic acid amine M1 with temperature-sensitive properties, inorganic nanopowder M2 and polyhydroxyalkanoate M3 with good biocompatibility, and the mass percentage of the amount of the three is: 94-60:1 120:5139. In the preparation method, M1, M2 and) M3 are subjected to in-situ free radical polymerization reaction in an aqueous solution, and the nanocomposite epoxy resin with biocompatibility and temperature sensitivity is obtained after soaking and removing impurities. The preparation process of this method is simple and easy to control, and the automatic desorption of cells can be realized by lowering the temperature. The biocompatibility and temperature sensitivity of epoxy resin can be adjusted by changing the density of crosslinking agent, the amount of M3 and the composition. Widely used in tissue engineering and other fields.

Description

technical field [0001] The invention relates to the field of biocompatible and environment-sensitive polymer materials, in particular to a biocompatible and temperature-sensitive nanocomposite epoxy resin and a preparation method thereof. The nanocomposite epoxy resin can be applied to the fields of tissue engineering and the like. Background technique [0002] Epoxy resin is a kind of hydrophilic cross-linked polymer between liquid and solid that can swell significantly in water and retain a large amount of water but cannot be dissolved in water. It can accommodate several times or even hundreds of times the weight of the polymer itself. of water. Environmentally sensitive epoxy resins can sense small changes or stimuli in the external environment (such as temperature, p11, light, electricity and pressure, etc.), and can produce corresponding changes in physical structure and chemical properties. In the change of the external environment, due to the controllability and si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F283/02C08F220/54C08F2/44C08K3/34A61L27/18A61L27/50A61L27/52
CPCC08F283/02A61L27/18A61L27/50A61L27/52C08F2/44C08K3/34C08K2201/003C08K2201/011C08F220/54C08L51/08
Inventor 丁伟
Owner 成都昂多生物技术有限责任公司
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