Metronidazole synthesizing device and metronidazole synthesizing method applying same

A synthesis device and synthesis method technology, applied in the direction of organic chemistry, etc., to achieve the effects of less investment in equipment, ensuring continuity, and saving resources

Active Publication Date: 2018-04-06
HUANGGANG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Recycled methyl formate can only be sold at a low price

Method used

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  • Metronidazole synthesizing device and metronidazole synthesizing method applying same

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Step 1): open the light component reflux valve (52), close the heavy component reflux valve (33), and add lower carbon alcohol formate, ethylene glycol and 2-methyl-5-nitroimidazole in the reaction kettle (20) , stir, add dropwise 85% formic acid, carry out transesterification to generate lower carbon alcohol and ethylene glycol formate, heat distillation, steam enters rectification column (10) rectification separation, wherein the formic acid lower alcohol ester of light component is from refined The rectification steam discharge port on the top of the distillation tower (10) is refluxed to the reactor (20) through the condenser (40) and the ester storage tank (50); The distillate outlet flows into the alcohol storage tank (30);

[0042] Step 2): When the temperature of the reactor (20) rises to the boiling point of the low-carbon alcohol, close the light component reflux valve (52), and when the temperature of the reactor (20) rises to above the boiling point of the l...

Embodiment 2

[0051] Step 1): open the light component reflux valve (52), close the heavy component reflux valve (33), and add lower carbon alcohol formate, ethylene glycol and 2-methyl-5-nitroimidazole in the reaction kettle (20) , stir, add the concentrated sulfuric acid dropwise, carry out transesterification reaction and generate lower carbon alcohol and ethylene glycol formate, heat distillation, steam enters rectification column (10) rectification separation, wherein the lower carbon alcohol ester of formic acid of light component from rectification The rectification steam discharge port on the upper part of the tower (10) passes through the condenser (40) and the ester storage tank (50), and then flows back to the reactor (20); The liquid outlet flows into the alcohol storage tank (30);

[0052] Step 2): When the temperature of the reactor (20) rises to the boiling point of the low-carbon alcohol, close the light component reflux valve (52), and when the temperature of the reactor (2...

Embodiment 3

[0061] Step 1): open the light component reflux valve (52), close the heavy component reflux valve (33), and add lower carbon alcohol formate, ethylene glycol and 2-methyl-5-nitroimidazole in the reaction kettle (20) , stir, add dropwise 98% vitriol oil, carry out transesterification to generate lower carbon alcohol and ethylene glycol formate, heat distillation, steam enters rectification tower (10) rectification separation, wherein the formic acid lower alcohol ester of light component from The rectification steam discharge port on the top of the rectification tower (10) is refluxed to the reactor (20) through the condenser (40) and the ester storage tank (50); The rectifying liquid outlet flows into the alcohol storage tank (30);

[0062] Step 2): When the temperature of the reactor (20) rises to the boiling point of the low-carbon alcohol, close the light component reflux valve (52), and when the temperature of the reactor (20) rises to above the boiling point of the low-c...

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PUM

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Abstract

The invention provides a metronidazole synthesizing device and a metronidazole synthesizing method applying the same. The device comprises a rectifying tower, a reaction kettle, an alcohol storage tank, a condenser and an ester storage tank. The synthesizing method achieves circular application of ethylene glycol in the metronidazole synthesizing process. The device and method provided by the invention have the beneficial effects that circular application of ethylene glycol in the metronidazole synthesizing process is achieved, the resources are saved, and meanwhile, the continuity of the synthesizing process is ensured, the solvent is used circularly, and the equipment investment is little.

Description

technical field [0001] The invention belongs to the field of organic synthesis, in particular to a metronidazole synthesis device and a metronidazole synthesis method using the device. Background technique [0002] Metronidazole is white or yellowish crystal or crystalline powder, used for the treatment of intestinal and parenteral amoebiasis (such as amebic liver abscess, pleural amoebiasis, etc.). It can also be used to treat vaginal trichomoniasis, cylindrosis, skin leishmaniasis, and guinea worm infection. At present, it is also widely used in the treatment of anaerobic infection, and is regarded as the drug of choice for anti-anaerobic bacteria by the World Health Organization (WHO). [0003] The current process of synthesizing metronidazole is to dissolve 2-methyl-5-nitroimidazole in formic acid, add ethylene oxide successively at 30-40°C, and add sulfuric acid in the middle of the addition. After addition, react for 1h to obtain hydroxylated solution. Use sodium hy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D233/94
CPCC07D233/94
Inventor 曾舟华曾彩红刘晓晖冉敬文黄林勇杨水彬
Owner HUANGGANG NORMAL UNIV
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