Unlock instant, AI-driven research and patent intelligence for your innovation.
Preparation method of allogeneic biological patch
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A biological patch, allogeneic technology, applied in tissue regeneration, medical science, surgery, etc., can solve problems such as no market precedent, reduce the incidence of capsular contracture, ensure accuracy, and optimize biocompatibility. sexual effect
Active Publication Date: 2018-04-10
BEIJING QINGYUAN WEIYE BIO TISSUE ENG
View PDF9 Cites 8 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
[0004] The biological patch products that have been on the market in China are only the biological patch of Guanhao Biological Co., Ltd. (National Machinery Injection No. 20153460482) and the breast soft tissue enhancement patch of pfm medical titanium gmbh (National Machinery Injection No. 20163461539). The former is an animal source products, the latter is made of polymer materials, and biological patch products of allogeneic origin have not yet been marketed.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
Smart Image
Examples
Experimental program
Comparison scheme
Effect test
preparation example Construction
[0041] The first group of embodiments, the preparation method of biological patch of the present invention
[0042] The embodiment of this group provides a preparation method of allogeneic biological patch. All embodiments of this group all possess following common features: described preparation method comprises the steps:
[0047] The phosphate buffer, preferably sodium phosphate buffer, can also be replaced by potassium phosphate buffer; of course, those skilled in the art can also choose to use other similar phosphate buffer according to the content described herein and according to actual needs , su...
experiment example
[0062] Experimental example, the specific operation of the preparation method of the present invention and the performance detection of biological patch products
[0063] Step A: select healthy adult skin tissue, remove subcutaneous fat; soak in 1mol / L-2mol / L NaCl solution at 37°C for 24 hours to remove the epidermis to obtain the dermis;
[0064] Step B: Through mechanical processing, according to different models and specifications, make corresponding shapes, such as rectangle, sector, circle, or punch holes;
[0065] Step C: In the process of removing the dermal cell substance, the collagen constituting the frame structure in the material and the attached special factors etc. are protected, fixed and restored by biochemical and tissue engineering methods.
[0066] Step D: Utilize the patented decellularization technology, add specific enzymes and chemical reagents to the alkaline solution of 1.5mol / L-2.0mol / L NaOH or KOH in the basic preparation solution to prepare decellul...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Property
Measurement
Unit
tensile strength
aaaaa
aaaaa
Login to View More
Abstract
The invention relates to a preparation method of an allogeneic biological patch, and belongs to the technical field of biological material preparation. The preparation method comprises the steps of 1,obtaining people's skin tissues and a corium layer; 2, placing the corium layer in a fixing solution to perform fixing treatment; 3, placing the fixed corium layer in a decellularization solution toperform decellularization treatment to obtain decellularization corium tissues. The fixing solution is a phosphatebuffer solution containing 1%-2% formaldehyde and 1.5%-3.0% o-phthalaldehyde; the decellularization solution is a 1.5-2.0 mol / L NaO or KOH alkaline solution containing 10-500 U / L trypsin, 1-25 mmol / L calciumchloride and 1-25 mmol / L magnesiumchloride. The allogeneic biological patchhas effective fixing and supporting effects on breast implants, and different sizes are designed to satisfy the requirement of different patients and operating methods; in addition, because extremelylow immunogenicity and extremely excellent biocompatibility of the allogeneic biological patch, it is expected that occurrence rate of diolame contracture after the breast implants are implanted can be significantly reduced.
Description
technical field [0001] The invention belongs to the technical field of biological material preparation, and in particular relates to a preparation method of an allogeneic biological patch technical background [0002] At present, the products that can be applied to breast reconstruction and plastic surgery in the domestic plastic surgery market are very mature. At the same time, there is also a huge market for biological patch products that are specially used to repair soft tissue defects, wrap breast prostheses, and suspend and stretch. need. There should be at least 300,000 cases of breast reconstruction and 100,000 cases of conventional breast augmentationsurgery in China every year. Soft tissue repair patch products have taken on the needs of professional application of biological patches in clinical practice, and there is a certain degree of There is an urgent need for matching biological patch products for over-range or irregular use. [0003] At present, the most w...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More