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Drink composition capable of inhibiting urinary calculi formation and promoting litholysis and application of drink composition

A technology for urinary calculi and beverages, which is applied in the field of beverage compositions for inhibiting the formation of urinary calculi and promoting dissolution of urinary calculi. Promote the effect of dissolving stone

Inactive Publication Date: 2018-04-20
南京伊登生物医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report about the prevention and treatment of urolithiasis by garcinia cambogia extract, nor is there any report on the composition of the present invention that inhibits urolithiasis formation and promotes dissolving stones

Method used

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  • Drink composition capable of inhibiting urinary calculi formation and promoting litholysis and application of drink composition
  • Drink composition capable of inhibiting urinary calculi formation and promoting litholysis and application of drink composition
  • Drink composition capable of inhibiting urinary calculi formation and promoting litholysis and application of drink composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation technology of garcinia cambogia extract:

[0029] (1) Cut the dried garcinia cambogia husk into small pieces, soak and extract in boiling water, and the extract is concentrated into an extract;

[0030] (2) adding ethanol to the extract to dissolve, filtering out the pectin to obtain a concentrated solution.

Embodiment 2

[0032] (1) Garcinia cambogia pericarp is soaked and extracted with ethanol, the ethanol volume used for each soak is 8 times of the quality of the Garcinia cambogia pericarp to be extracted, soaked for 48 hours each time, soaked and extracted 3 times altogether, combined ethanol soaked extract, reduced Concentrate absolute ethanol under pressure to obtain extract A.

[0033] (2) Separation of extract A by silica gel column chromatography: the amount of silica gel is 18 times that of extract, and the specification is 200 mesh. Extract A is eluted by silica gel column chromatography with chloroform, and 8 column volumes are eluted , concentrating the chloroform eluate under reduced pressure to obtain extract B, and the extract B was dried to obtain Garcinia cambogia extract.

[0034] The Garcinia cambogia extract used in the following examples was prepared by the preparation process of this example.

Embodiment 3

[0036] 1. Animal experiment group:

[0037] 24 specific pathogen-free (SPF) grade male SD rats, weighing 200-250 g. After feeding with normal pellet feed and tap water for 1 week to adapt to the environment, they were randomly divided into three groups with 8 rats in each group. A group (control group): normal pellet feed and tap water feeding in the experiment; Feeding with tap water; Group C (Garcinia Cambogia Extract Intervention Group): in the experiment, drink the Garcinia Cambogia Extract containing 1% ammonium chloride and 1% ethylene glycol solution 2ml / d for gavage+2%, normal pellet feed and Feed with tap water.

[0038] 2. Specimen collection:

[0039] The experiment was carried out for 2 weeks, and one day before the rats were killed, each male SD rat was placed in a clean-grade open metabolic cage, and urine was collected for 24 hours to detect urine-related indicators. The next day, after intraperitoneal anesthesia with 3% pentobarbital sodium (40mg / kg), routi...

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Abstract

The invention relates to a drink composition capable of inhibiting urinary calculi formation and promoting litholysis and an application of the drink composition. The invention relates to a novel application of a garcinia cambogia extract, namely, an application of the garcinia cambogia extract in preparation of food or drugs for inhibiting urinary calculi formation and promoting litholysis. The invention also provides a drink capable of inhibiting urinary calculi formation and promoting litholysis. The drink has the advantages as follows: animal experiments find that the garcinia cambogia extract can inhibit urinary calculi formation and promote litholysis for the first time. The concentration of 24 h urinary oxalic acid and calcium ions in rats in a garcinia cambogia extract interventiongroup is significantly reduced as compared with a calculus induction group; dotted calcium oxalate crystals can be seen in kidney tubules in the garcinia cambogia extract intervention group, flaky calcium oxalate crystals are seldom seen, and the um oxalate crystal deposition and lumen expansion conditions are remarkably better than those in the calculus induction group.

Description

technical field [0001] The invention relates to the technical fields of food and medicine, in particular to a beverage composition for inhibiting the formation of urinary stones and promoting stone dissolution and its application. Background technique [0002] Kidney calculus is a common, multiple, and complex disease of body mineralization caused by environmental diet factors and genetic factors. The incidence rate is as high as 10-20%, and it has a great impact on the life, work and health of patients. At present, there are mainly four types of treatment methods to the treatment of kidney stone disease: general treatment (plenty of drinking water, intramuscular injection of straight-through medicine, medicine to expel stones), extracorporeal shock wave lithotripsy, intracavitary surgery and open surgery. [0003] Calcium oxalate stones are the most common type of urinary calculi. Currently, the drugs that have an intervention effect on urinary calculi are mainly to adjust ...

Claims

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Application Information

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IPC IPC(8): A23L2/38A23L33/105A61K36/185A61P13/04
CPCA23L2/38A23L33/105A61K36/185A23V2002/00A23V2200/30A23V2250/054A23V2250/21A23V2250/262A23V2300/14A23V2300/50
Inventor 孙一仟鄢赵婉云毛徐婷梅琴琴谢旻皓
Owner 南京伊登生物医学科技有限公司
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