21 results about "Oxalate crystals" patented technology

The invention discloses a gemigliptin oxalate and a crystal form, a preparation method and application thereof, relates to the technical field of medicinal chemistry, and provides the crystal form of the gemigliptin oxalate, the crystal form is not reported in the prior art, and animal experiments show that compared with gemigliptin tartrate and gemigliptin hydrochloride, the crystal form of the gemigliptin oxalate has the advantages that the crystal form of the gemigliptin oxalate is more stable. The gemigliptin oxalate prepared by the invention has better pharmacokinetic performance, and lays a foundation for development and application of a new dosage form of gemigliptin; the invention further provides a simple and efficient gemigliptin salt forming process, compared with a method for removing an amino protecting group through acid treatment, the salt forming process provided by the invention does not need to add alkali to dissociate the amino group, impurity generation caused by strong acid or strong alkali is avoided, and the prepared gemigliptin oxalate is high in purity.

The utility model discloses a rare earth recovery device for a rare earth wastewater solution, and belongs to the technical field of rare earth production. Comprising a cooling box, a precipitation barrel is arranged in an inner cavity of the cooling box, the upper portion of the precipitation barrel and a lower inner cavity of the cooling box are sealed through a sealing plate, an opening of the precipitation barrel is communicated with an upper inner cavity of the cooling box, a feeding pipe and a discharging pipe are symmetrically arranged on the upper portion of the cooling box, and the feeding pipe is communicated with the side wall of the middle of the precipitation barrel; the discharging pipes are communicated with the inner cavities of the upper portions of the cooling boxes, and the discharging pipe of any cooling box is communicated with the feeding pipe of the adjacent cooling box. The precipitation cylinder is arranged in the cooling box, so that the rare earth wastewater can be quickly cooled, the crystallization of praseodymium neodymium oxalate in the rare earth wastewater is accelerated, and the recovery of praseodymium neodymium oxalate is accelerated. In addition, the filter screen disc filters praseodymium neodymium oxalate crystals, excessive filtered praseodymium neodymium oxalate crystals are prevented from entering the next cooling box, praseodymium neodymium oxalate is recycled through the multiple cooling boxes, and waste of praseodymium neodymium oxalate is prevented.

A quinazoline derivative (represented by the formula (I)) salt's crystal form, a preparation method and application are provided; specifically, the hydrochloride crystal form A, B, C, D, F, H, I, Sulphate crystal form A, Maleate crystal form A, Succinate crystal form A, Adipate crystal form A, Glycolate crystal form A, Malate crystal form A, Fumarate Salt crystal form A, besylate crystal form A, B, C, benzoate crystal form A, hippurate crystal form A and oxalate crystal form A of the quinazoline derivative represented by formula (I). The salt crystal form provided by the present invention has good stability, which can be used in the treatment of non-small cell lung cancer brain metastasis, meningeal metastasis, primary brain cancer or glioma, etc., and has good bioavailability, which is of great significance for further research on the efficacy of such solid drugs.

The invention provides a preparation method of ferrous oxalate, which comprises the following steps: S1, mixing and grinding fine iron powder and alkali, and roasting the obtained mixed material to obtain a roasted material; s2, mixing the roasted material with water and polyhydric alcohol for water leaching, and taking a solid phase after solid-liquid separation to obtain primary filter residues; and S3, mixing the primary filter residues with an acid solution, carrying out acid leaching, adjusting the pH value, carrying out solid-liquid separation, taking a solid phase to obtain secondary filter residues, mixing the secondary filter residues with oxalic acid and a reducing agent, and carrying out a heating reaction to generate ferrous oxalate crystals. The invention aims to develop an alkali roasting-water leaching-acid leaching and precipitation process, so that silicon, aluminum, boron, calcium and magnesium impurities in the fine iron powder are efficiently and synergistically removed, and ferrous oxalate with high additional value is mainly produced.

The invention belongs to the technical field of crystal form drug molecules, and discloses a baricitinib oxalate crystal form and a preparation method thereof. The invention particularly relates to a crystal form 1 and a crystal form 2 of Baricitinib oxalate and a preparation method of the crystal form 1 and the crystal form 2. And the stability and solubility of the compound are investigated. It is found that the stability or solubility of the compound is improved to a certain extent. And the two crystal forms are simple in preparation process. Good industrialization prospects are realized.

This application provides a method for deep removal of calcium impurities from scandium oxide, belonging to the field of rare earth metal oxide purification. The method includes: dissolving scandium oxide raw material containing calcium impurities to obtain a calcium-containing scandium solution; adding a pH adjuster to the calcium-containing scandium solution to obtain a first scandium solution; reacting the first scandium solution with phosphoric acid and / or phosphate to obtain a second scandium solution and solid calcium phosphate; reacting the second scandium solution with a complexing agent to obtain a third scandium solution; reacting the third scandium solution with oxalic acid and / or sodium oxalate to obtain scandium oxalate crystals and a calcium complex solution; adding a strong acid solution to the calcium complex solution; and calcining the scandium oxalate crystals to obtain scandium oxide. Through calcium phosphate precipitation-complexation-crystallization, not only can calcium impurities be deeply removed from scandium oxide products, but impurities such as iron, titanium, and zirconium can also be removed, resulting in scandium oxide products with a purity of over 99.99%.

The invention discloses a method for recovering ferrous oxalate from waste lithium iron phosphate oxalic acid extraction slag, which comprises the following steps: (1) leaching: leaching the extraction slag through hydrochloric acid to separate carbon powder and a binder, and allowing iron, aluminum and copper elements and oxalate in the slag to enter an acid leaching solution; and (2) purification: adding excessive iron powder into the acid leaching solution to remove copper impurities, and filtering and separating to obtain a solution containing ferrous oxalate. And (3) acid recovery: carrying out reduced pressure distillation on the solution containing ferrous oxalate, recovering hydrochloric acid from a gas phase, and recycling the hydrochloric acid to a leaching section. And (4) recovery of ferrous oxalate: freezing the liquid phase to recover ferrous oxalate crystals, circulating mother liquor to a reduced pressure distillation section, and after several times of circulation, leading out the mother liquor from a bypass for deep treatment.

The invention discloses a liposome preparation prepared from a benzoyl guanidine derivative LY104 crystal form as well as a preparation method and application of the liposome preparation, and belongs to the technical field of medicines. The invention provides a liposome for inflammatory lung diseases, which takes LY104 and a novel crystal form thereof as active ingredients. The liposome prepared by the invention is good in stability, stable in membrane drug loading, and suitable for atomization drug delivery, and the particle size can be controlled to be 50-200nm. Meanwhile, the liposome preparation provided by the invention can delay drug release, prolong the onset time, improve the tolerated dose of single administration, reduce drug irritation, and can be used for treating inflammatory lung diseases, after being freeze-dried, the liposome preparation provided by the invention is dispersed in saline water to be atomized and inhaled, so that the bitter taste of the drug can be greatly covered, and the bioavailability of the drug is improved. The lipidosome preparation has the advantages that drug irritation is reduced, drug bioavailability is improved, patient compliance is improved, the lipidosome preparation can optimize the in-vivo metabolic process of the benzoyl guanidine derivative, the curative effect of the benzoyl guanidine derivative on treating inflammatory lung diseases is enhanced, and the application prospect is wide. The liposome preparation provided by the invention can be used for treating inflammatory lung diseases such as asthma, chronic obstructive pulmonary disease and the like in a more targeted manner, and has a wide market application prospect.

The invention belongs to the technical field of iron product surface pretreatment, and particularly discloses an iron product and a surface treatment method thereof. A layer of chemical conversion film is formed on the surface of the iron product, and the chemical conversion film mainly contains ferrous oxalate crystals. The chemical conversion film is covered with a conversion protection film, and the chemical conversion film and the conversion protection film are compounded to form a crystalline film layer. According to the method, an oil removal and rust removal chemical conversion one-step method is firstly adopted, oil stains and rust on the surface of the ironwork can be removed, a layer of ferrous oxalate crystal chemical conversion film is formed on the surface of the ironwork, then drip drying and reverse embroidering are conducted, then secondary conversion and surface conditioning are conducted, a composite crystalline film layer is formed, and the problem that in the technology, powder generation and reverse rusting are prone to occurring in the film drying process is solved. According to the method, the technological process is simple, the output of waste water and solid waste is greatly reduced, the corrosion resistance and adhesive force of the obtained product are good, and the comprehensive cost is lower.

The invention provides a preparation method of an aluminum-containing oxalate piezo-electric crystal. The chemical formula of the aluminum-containing oxalate piezo-electric crystal is NaBaAl (CO). 5HO, the molecular weight is 541.45, the aluminum-containing oxalate piezo-electric crystal is crystallized in an orthorhombic system polar space group Pca2 (No.29), and the cell parameters are as follows: a = 19.0829 (4), b = 10.8321 (3), c = 16.4577 (4), alpha = beta = gamma = 90 degrees, V = 3401.94 (14) 3 and Z = 8. The aluminum-containing oxalate crystal realizes a non-centrosymmetric structure so as to have piezoelectric response, d33 of the aluminum-containing oxalate crystal is obviously higher than that of quartz, meanwhile, the problem of environmental pollution of a Pb-based material is avoided, and a feasible solution is provided for developing a novel green and high-performance piezoelectric material.

The utility model relates to a rare earth recovery device, belongs to the technical field of rare earth recovery, and particularly relates to a rare earth recovery device for rare earth wastewater solution, which comprises a cooling box, a top cover is fixedly connected onto the cooling box, a precipitation cylinder is fixedly connected onto the top cover, and a feeding pipe is fixedly connected onto the top cover; according to the praseodymium neodymium oxalate crystal discharging device, the sliding groove, the sliding block, the filter screen, the rotating shaft and the hydraulic rod are matched, the hydraulic rod is used for driving the filter screen to move upwards, praseodymium neodymium oxalate crystals move upwards along with the filter screen, the praseodymium neodymium oxalate crystals are separated from rare earth waste water through the filter screen, and the situation that waste water rare earth is discharged when the praseodymium neodymium oxalate crystals are discharged is effectively avoided; through cooperation of the protective shell, the motor, the rotating shaft, the scraping strip and the scraping plate, the motor is used for driving the scraping strip to rotate to prevent praseodymium neodymium oxalate crystals from blocking the filter screen, the scraping strip is used for driving the scraping plate to rotate to clean the inner wall of the precipitation barrel, and the praseodymium neodymium oxalate crystals are prevented from adhering to the inner wall of the precipitation barrel to cause waste.

The present disclosure is directed to processing iron-containing feedstocks using oxalic acid to cost-effectively and cleanly transform low-cost iron feedstocks into iron-containing products (e.g., metallic iron and / or iron oxide) of high purity. In general, the methods of production using the systems described herein may include leaching low-purity iron feedstocks using a lixiviant including oxalic acid and an iron-complexing additive. The iron-complexing additive may suppress formation of iron (II) oxalate crystals and iron (III) oxalate crystals as leaching of a low-purity iron feedstock is carried out using oxalic acid, thus improving process kinetics and increasing the amount of iron that goes into solution during the leaching operation and ultimately recovered as a high-purity iron-containing product (e.g., metallic iron and / or iron oxide).

The invention discloses an oxalate seed crystal induced precipitation method and device in an alumina seed precipitation system, and belongs to the technical field of alumina production. The invention relates to an oxalate seed crystal induced precipitation method in an alumina seed precipitation system. The method comprises the following steps: S1, low-temperature induced precipitation; introducing the seed precipitation mother liquor into a purification tank, and reducing the solubility of oxalate under a low-temperature condition; s2, circularly inducing the seed crystals to form balls; introducing oxalate seed crystals into the purification tank to form crystal nucleuses to induce oxalate to directionally grow into spherical particles; s3, dynamic separation; discharging from the bottom of the purification tank, intercepting spherical oxalate particles through a screening structure, and returning mother liquor to a production process. The method is simple in process and easy to operate, does not need a complicated process flow, and is easy to implement on an existing aluminum oxide production line; the cost is low: existing equipment and process conditions are fully utilized, additional equipment investment does not need to be increased, and the process is relatively simple; the separated spherical oxalate particles are large in particle size and easy to separate from the mother liquor, so that the removal effect is improved.

The embodiment of the invention provides a method for one-step crystallization of scandium oxalate in a scandium-containing solution, the mass concentration of scandium in the scandium-containing solution is smaller than or equal to 1 g / L. The method comprises the steps that the pH value of the scandium-containing solution is adjusted to 0.5-2, and a pretreated scandium-containing solution is obtained; under the heating and stirring conditions, oxalic acid and a solventing-out agent are added into the pretreated scandium-containing liquid for a crystallization reaction, and crystallized slurry is obtained; carrying out solid-liquid separation on the crystallized slurry to obtain scandium oxalate crystals; and washing and drying the scandium oxalate crystal to obtain scandium oxalate. The crystallization process of scandium oxalate is optimized chemically and physically through key steps of adjusting the pH value, adding a solvating-out agent, controlling the dosage of oxalic acid, heating, stirring and the like. According to the process conditions, the complex process difficulty of crystallizing scandium oxalate from the low-concentration scandium-containing solution is overcome, the energy consumption of an evaporation and concentration procedure and the large consumption of materials such as an extracting agent in a multi-time extraction process are reduced, and low-consumption and rapid crystallization of scandium oxalate is realized.

The invention discloses a method for preparing high-purity iron oxide red by utilizing jarosite slag, which comprises the following steps: mixing the jarosite slag with an oxalic acid solution, carrying out solid-liquid separation on a reaction product to obtain a zinc-powder-rich product, adding oxalic acid into an iron-rich complex ion Fe (C2O4) 33 <-> leaching solution to reduce iron powder so as to convert the iron powder into ferrous oxalate crystal precipitate, and carrying out solid-liquid separation on the iron-rich complex ion Fe (C2O4) 33 <-> leaching solution to obtain the high-purity iron oxide red. High-purity battery-grade ferrous oxalate powder is obtained through vacuum drying treatment, roasting is conducted under the inert atmosphere condition, a high-purity iron oxide red product with the purity larger than or equal to 98.5% and the particle size meeting the battery-grade use standard is finally obtained, and finally resource utilization and high-value utilization of the jarosite slag are achieved. The method provided by the invention not only overcomes the defects of long process flow, high energy consumption and high smelting cost of traditional jarosite slag treatment, but also solves the difficult problem of dangerous waste treatment for enterprises, generates various products with high added values, and has remarkable social benefits and economic benefits.

A quinazoline derivative (represented by the formula (I)) salt's crystal form, a preparation method and application are provided; specifically, the hydrochloride crystal form A, B, C, D, F, H, I, Sulphate crystal form A, Maleate crystal form A, Succinate crystal form A, Adipate crystal form A, Glycolate crystal form A, Malate crystal form A, Fumarate Salt crystal form A, besylate crystal form A, B, C, benzoate crystal form A, hippurate crystal form A and oxalate crystal form A of the quinazoline derivative represented by formula (I). The salt crystal form provided by the present invention has good stability, which can be used in the treatment of non-small cell lung cancer brain metastasis, meningeal metastasis, primary brain cancer or glioma, etc., and has good bioavailability, which is of great significance for further research on the efficacy of such solid drugs.

The present disclosure is directed to processing iron-containing feedstocks using oxalic acid to cost-effectively and cleanly transform low-cost iron feedstocks into iron-containing products (e.g., metallic iron and / or iron oxide) of high purity. In general, the methods of production using the systems described herein may include leaching low-purity iron feedstocks using a lixiviant including oxalic acid and an iron-complexing additive. The iron-complexing additive may suppress formation of iron (II) oxalate crystals and iron (III) oxalate crystals as leaching of a low-purity iron feedstock is carried out using oxalic acid, thus improving process kinetics and increasing the amount of iron that goes into solution during the leaching operation and ultimately recovered as a high-purity iron-containing product (e.g., metallic iron and / or iron oxide).

The invention discloses a urine calcium oxalate crystal detection device and a use method thereof, and relates to the technical field of medical detection equipment, the urine calcium oxalate crystal detection device comprises a collection structure, the collection structure is used for collecting urine, the collection structure comprises a first container and a second container, the first container is provided with a first port, the second container is provided with a second port and a third port, the first port is detachably connected with the second port. The detection structure is used for detecting the collected urine and comprises a third container, a fourth container and a sealing assembly, the third container is provided with a fourth port, the fourth port is detachably connected with the third port, the third container is filled with a reaction substance, the fourth container is arranged above the third container, the bottom end of the fourth container is open, and the sealing assembly is connected with the fourth container. The top end of the third container is open, a sealing assembly is arranged between the bottom end of the fourth container and the top end of the third container, and the fourth container is filled with an indole solution. The method has the advantages that convenient detection of calcium oxalate crystals is realized, and a patient can detect and observe the change of an illness state by himself / herself.

The application belongs to the technical field of crystal form drug molecules, and particularly relates to an axitinib oxalate crystal form and a preparation method and application thereof. The axitinib oxalate crystal form provided by the application is composed of one molecule of axitinib, one molecule of oxalic acid and two molecules of water as a basic unit of the crystal form, has high solubility, good stability, a simple preparation method, good reproducibility and is suitable for industrialized production.

A method for preparing ferrous oxalate includes: dissolving an iron source and performing a reduction operation to obtain a first solution; adding a first liquid oxalic acid to the first solution and mixing and reacting to obtain a second solution; adding solid oxalic acid to the second solution and mixing and reacting to obtain a third solution containing a first reaction product; and removing impurities from the first reaction product to obtain ferrous oxalate. The ferrous oxalate has particle sizes including D10, D50, and D90, and its uniformity coefficient is (D90-D10) / D50, satisfying: 20μm≤D50≤60μm, 1.8≤(D90-D10) / D50≤8. This method can prepare both small- and large-particle-size ferrous oxalate, thus broadening the particle size range of ferrous oxalate crystals.

The invention belongs to the technical field of crystal form medicine molecules, and particularly relates to an axitinib oxalate crystal form as well as a preparation method and application thereof. According to the axitinib oxalate crystal form provided by the invention, a basic unit of the crystal form is formed by combining one molecule of axitinib with one molecule of oxalic acid and two molecules of water, the solubility is high, the stability is good, the preparation method is simple to operate, the reproducibility is good, and the axitinib oxalate crystal form is suitable for industrial production.