Traditional Chinese medicine polysaccharide for treating acute liver injury and preparation method thereof
A technology for acute liver injury and traditional Chinese medicine, applied in the field of traditional Chinese medicine polysaccharide and its preparation, can solve the problems of weak targeted drug delivery, life-threatening and other problems, achieve the effect of significant liver injury, promote recovery, and solve difficult treatment effects
Active Publication Date: 2020-02-07
ANHUI AGRICULTURAL UNIVERSITY
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Problems solved by technology
However, some studies have shown that some anti-hepatic drugs will inevitably produce biological toxicity, which is dangerous to life, and the targeted drug delivery is not strong
It can be seen that the prevention and treatment of liver injury is still a serious issue
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[0028] 1 material
[0029] 1.1 Animals Clean-grade male SD rats, weighing 180-220 g, aged 5 weeks. Bought from Airmate Technology Co., Ltd., the animal license number is SCXK (Su) 2014-0007.
[0030] 1.2 The test product Polygonatum was purchased by Hefei Shennan Chinese Medicine Pieces Co., Ltd. The preparation process of the traditional Chinese medicine polysaccharide of the present invention is as follows: firstly, the Rhizoma Rhizoma Polygonatum decoction piece is carried out preliminary pulverization, makes the drug coarse powder of about 20 orders; Reflux extraction at ℃ for 6 hours, discard the ethanol extract, take the dregs and dry them; take the dregs after drying, extract them in a water bath at 73°C for 4 h according to the mass ratio of dregs:water at 1:19, filter, and take the filtrate The above-mentioned filtrate is heated and concentrated until the relative content of the original medicinal material is 1g / mL; the concentrated filtrate is precipitated by filtr...
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The invention discloses traditional Chinese medicinal polysaccharide for treating acute hepatic injury and a preparation method of the traditional Chinese medicinal polysaccharide. The traditional Chinese medicinal polysaccharide is polygonatum sibiricum polysaccharides. An animal experiment shows that the traditional Chinese medicinal polysaccharide has obvious anti-inflammatory and antioxidationeffects and no toxic and side effects; by means of the traditional Chinese medicinal polysaccharide, repair of the hepatic injury induced by carbon tetrachloride can be promoted in a short time, andthe problem that clinical acute hepatic injury is difficult to treat is effectively solved. An extraction mode of the traditional Chinese medicinal polysaccharide is a water-extraction and alcohol-precipitation method. The water-extraction and alcohol-precipitation method comprises the following steps: firstly, carrying out single-factor experiment on three main factors such as liquid-solid ratio,temperature and time, which affect the extraction rate; secondly, optimizing an extraction technology by using a response surface analysis method; finally, obtaining a preparation technology with simple process flow and high extraction rate. The preparation technology is suitable for industrial batch production. An effective low-toxicity drug for treating the hepatic injury has a broad prospect and is easily and clinically popularized and applied.
Description
technical field [0001] The invention relates to a traditional Chinese medicine polysaccharide for treating acute liver injury and a preparation method thereof. Background technique [0002] Liver injury is the result of various liver diseases, mainly caused by drugs, alcohol, biology, virus, environment and other factors, including physical liver injury, chemical liver injury, alcoholic liver injury, environmental liver injury and metabolic liver injury. Hepatic injury and other various liver injuries are serious and frequently-occurring common diseases in my country at present. Liver failure or its complications can lead to death and pose a major threat to human health. In view of this, it is very urgent and necessary to research and develop liver injury drugs with good therapeutic effects. [0003] With the rapid development of medical technology, there have been many studies and reports on drugs for the treatment of liver injury, mainly including Chinese herbal medicines...
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IPC IPC(8): A61K31/715A61P1/16
CPCA61K31/715A61K36/8969
Inventor 刘翠艳韩春杨罗泽华杨明川杨孜生
Owner ANHUI AGRICULTURAL UNIVERSITY