Formula of 3D-printing artificial bone composite fiber protein scaffold and preparation method of same

A protein scaffold and composite fiber technology, applied in the field of medicine, can solve the problems of immune rejection, spread of diseases, bleeding in the bone harvesting area, etc., and achieve the effect of promoting bone regeneration, good bone conduction and osteoinduction, and inducing osteogenic differentiation.

Active Publication Date: 2018-05-15
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
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Problems solved by technology

Although autologous bone transplantation is the gold standard of treatment, it will cause bleeding and infection in the bone harvesting area during the transplantation process; there is a risk of

Method used

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  • Formula of 3D-printing artificial bone composite fiber protein scaffold and preparation method of same
  • Formula of 3D-printing artificial bone composite fiber protein scaffold and preparation method of same
  • Formula of 3D-printing artificial bone composite fiber protein scaffold and preparation method of same

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Embodiment Construction

[0023] In the following, numerous specific details are set forth in order to provide a thorough understanding of the concepts underlying the described embodiments. It will be apparent, however, to one skilled in the art that the described embodiments may be practiced without some or all of these specific details. In other instances, well known processing steps have not been described in detail.

[0024] The formula of 3D printing artificial bone listed in this example is made of the following raw materials: medical grade collagen powder, 0.05mol / L acetic acid solution, medical grade hydroxyapatite powder, and 1% genipin solution by mass fraction.

[0025] The formula and preparation method thereof of 3D printing artificial bone composite fibrin scaffold according to claim 1, is characterized in that: carry out according to the following steps:

[0026] (1), preparation of collagen colloid: 5g of medical grade collagen powder is dissolved in 0.05mol / L acetic acid solution of 2...

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Abstract

The invention discloses a formula of a 3D-printing artificial bone composite fiber protein scaffold and a preparation method of same, the scaffold includes five components: medical-grade collagen powder, a 0.05 mol/L acetic acid solution, medical-grade hydroxylapatite powder, a 1 mass% genipin solution, and platelet-rich fibrin. The preparation method includes the steps of: 1) dissolving the medical-grade collagen powder in the 0.05 mol/L acetic acid solution to obtain collagen colloid; 2) uniformly stirring the medical-grade hydroxylapatite powder and collagen colloid to prepare a hydroxylapatite/collagen printing raw material, and according to bone defect CT data of a patient, printing a hollow individual tissue-engineered bone by means of a 3D bio-printing machine; 3) during an operation process of transplanting the artificial bone scaffold, centrifuging blood of the patient to prepare the platelet-rich fibrin, and injecting the platelet-rich fibrin into the tubular cavity in the tissue-engineered bone to obtain the artificial bone which contains the hydroxylapatite, collagen and platelet-rich fibrin and has capability of improving osteanagenesis of human body. The artificial bone can slowly release the autologous growth factor in the platelet-rich fibrin of the patient, thus improving recovery of the osteanagenesis of human body.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a formula of 3D printing artificial bone composite fibrin scaffold and a preparation method thereof. Background technique [0002] The repair of large bone defects has always been a difficult problem for orthopedic surgeons. The current repair strategies include autologous bone, allogeneic bone, and artificial material transplantation. Although autologous bone transplantation is the gold standard of treatment, it will cause bleeding and infection in the bone harvesting area during the transplantation process; there is a risk of immune rejection and disease transmission in allogeneic bone transplantation; the rapid development of bone tissue engineering has greatly reduced the Repair provides a more feasible method. The internal structure of the stent prepared by the traditional method is often uncontrollable, and the 3D printing technology can tailor the shape of th...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/42A61L27/54B29C64/112B33Y10/00
CPCA61L27/225A61L27/425A61L27/54A61L2300/414A61L2430/02B33Y10/00C08L89/00
Inventor 毕龙宋岳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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