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A porous metal bone implant material and its preparation method and application

A technology of bone implant material and porous metal, which is applied in the field of porous metal bone implant material and its preparation, can solve the problems of difficulty in growing bone tissue, and the pores of porous materials should not be too small, so as to improve biological inertness and maintain natural raw materials. Has attributes and promotes good integration effects

Inactive Publication Date: 2020-09-15
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, in order to effectively reduce the stress barrier at the interface, the pores of the porous material should not be too small, which in turn makes it difficult for bone tissue to grow into the pores.

Method used

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  • A porous metal bone implant material and its preparation method and application
  • A porous metal bone implant material and its preparation method and application
  • A porous metal bone implant material and its preparation method and application

Examples

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preparation example Construction

[0038] The preparation method of the porous metal bone implant material disclosed by the present invention comprises the following steps:

[0039] Step 1: Prepare individualized and customized 3D printed metal implant materials. Collect the patient's CT image data, analyze and design the individualized implant material shape and internal pore structure for the patient in the 3D image software. Wherein, the rod width is 100-800 μm, the pore diameter is 100-1000 μm, and the image is filled and expanded with cube or regular dodecahedral structural units to obtain a three-dimensional image of the target implant. The three-dimensional image file is imported into a metal material 3D printer to prepare a porous metal implant whose shape and pore structure are consistent with the design graphics. Implant materials were ultrasonically cleaned in alcohol, acetone, and distilled water for 20 minutes each to remove surface dirt, and dried in an oven at 50-60°C or air-dried for later use....

Embodiment 1

[0045] Example 1 Preparation of a porous metal bone implant material for people with diabetes

[0046] 1. Prepare individualized and customized 3D printing metal implant materials.

[0047] (1) For diabetic patients, collect the CT image data of the patient's bone defect, import it into the three-dimensional image software CAD, and design the shape and internal pore structure of the individualized target implant material according to the specific conditions of the patient. Among them, the width of the rod is 200 μm, and the average pore diameter is 400 μm. The image is filled and expanded with cube structural units to obtain a three-dimensional image of the target implant.

[0048] (2) Import the three-dimensional image file into the electron beam melting (EBM) metal material 3D printer, and use Ti with a diameter of 30 μm 6 Al 4 V alloy powder, through 3D printing to prepare individualized porous metal implants, see figure 1 .

[0049] (3) The porous metal implant materia...

Embodiment 2

[0058] Example 2 Preparation of a porous metal bone implant material for people with diabetes

[0059] This embodiment is partly the same as the embodiment, the difference is:

[0060] 1. In the first step, the width of the porous metal rod designed in the CAD software is 400 μm, the average pore diameter is 800 μm, and the pores of the material are filled with regular dodecahedral structural units. Using chromium-cobalt-molybdenum alloy microspherical material powder with a diameter of 20 μm, electron beam fusion 3D prints a porous metal material matrix.

[0061] 2. In the second step, the ratio of the dry weight of silk fibroin to the total volume of pores inside the material is 0.1g: 1cm 3 The proportion of silk fibroin is weighed, dissolved to prepare a silk fibroin solution, and set aside.

[0062] 3. In the third step, weigh the agonist AdipoRon of the adiponectin receptor, wherein the mass ratio of AdipoRon to silk fibroin is 1:1×10 4 . Add AdipoRon to the silk fibr...

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Abstract

The invention discloses a porous metal bone implant material and its preparation method and application and belongs to the technical field of biomedical materials. The porous metal bone implant material comprises a porous metal material matrix and a silk fibroin material filling the pores of the porous metal material matrix. The porous metal material matrix is prepared from metal raw material powder through 3D printing. The silk fibroin material is loaded with a bioactive drug. The preparation method comprises 1) preparing a customized 3D printed porous metal material matrix according to demands, 2) preparing a silk fibroin solution and loading the silk fibroin with a bioactive drug, and 3) filling pores of the porous metal material matrix with the silk fibroin with the bioactive drug, and carrying out freeze-drying to obtain the porous metal bone implant material. The porous metal bone implant material is precisely controlled in structure, can be customized, can effectively improve osseointegration of a metal bone implant in diabetic patients and can reduce the loosening rate of the implant.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a porous metal bone implant material and its preparation method and application. Background technique [0002] Bone defects caused by trauma, disease, etc. cause great suffering to patients. In bone injury repair and functional reconstruction, bone implants made of medical metal materials, such as medical metal screws, artificial joints, oral implants, etc., play an irreplaceable role in bone defect repair and functional reconstruction. The good integration and long-term stability of bone implants with the host bone are critical to the clinical prognosis of patients. [0003] Diabetes is a worldwide public health problem, and my country has already become the largest country in the world with diabetes. In 2010, the number of people with diabetes in the world has reached 382 million, of which my country accounted for 113.6 million, with a prevalence rate...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/22A61L27/04A61L27/06A61L27/56A61L27/54A61L27/50B33Y70/00B33Y10/00B33Y80/00
CPCA61L27/045A61L27/06A61L27/227A61L27/50A61L27/54A61L27/56A61L2300/252A61L2430/02B33Y10/00B33Y70/00B33Y80/00C08L89/00
Inventor 雷伟胡晓帆冯亚非王林相庚陆奕兆
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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