Glipizide lipid nanoparticle solid preparation
A technology for glipizide lipid and solid preparation, which is applied in the field of medicine and achieves the effects of high encapsulation efficiency, narrow particle size distribution and improved quality
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[0045] Example 1 Preparation of Glipizide Lipid Nanoparticle Tablets
[0046] (1) Preparation of glipizide solid lipid nanoparticles
[0047] The prescription is as follows:
[0048] Glipizide 10 g
[0049] Glycerol trilaurate 140 g
[0050] Tween 80 80 g
[0051] Chitosan 28 g
[0052] The preparation method is as follows:
[0053] (A) Add 140 g of glycerol trilaurate to 500 mL of ethanol and acetone mixed solution with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, and then add 10 g of glipizide and stir Dissolve it to form an organic phase for use;
[0054] (B) Add 80 g of Tween (80) and 28 g of chitosan to 500 mL of purified water, heat it in a constant temperature water bath at 55 ℃, stir to dissolve it, and form the water phase for use;
[0055] (C) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 ℃, and stir for 30 minutes;
[0056] (D) Concentrate under reduced pressure...
Example Embodiment
[0072] Example 2 Preparation of Glipizide Lipid Nanoparticle Tablets
[0073] (1) Preparation of glipizide solid lipid nanoparticles
[0074] The prescription is as follows:
[0075] Glipizide 10 g
[0076] Glycerol trilaurate 120 g
[0077] Tween 80 68 g
[0078] Chitosan 32 g
[0079] The preparation method is as follows:
[0080] (A) Add 120 g of glycerol trilaurate to 500 mL of ethanol and acetone mixed solution with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, and then add 10 g of glipizide and stir Dissolve it to form an organic phase for use;
[0081] (B) Add 68 g of Tween (80) and 32 g of chitosan to 500 mL purified water, heat it in a constant temperature water bath at 55 ℃, stir to dissolve it, and form the water phase for use;
[0082] (C) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 ℃, and stir for 30 minutes;
[0083] (D) Concentrate under reduced pressure to...
Example Embodiment
[0099] Example 3 Preparation of Glipizide Lipid Nanoparticle Capsules
[0100] (1) Preparation of Glipizide Solid Lipid Nanoparticles
[0101] The prescription is as follows:
[0102] Glipizide 10 g
[0103] Glycerol trilaurate 160 g
[0104] Tween 80 90 g
[0105] Chitosan 20 g
[0106] The preparation method is as follows:
[0107] (A) Add 160 g of glycerol trilaurate to 500 mL of ethanol and acetone mixed solution with a volume ratio of 1:1, heat in a constant temperature water bath at 55°C, stir to dissolve, then add 10 g of glipizide and stir Dissolve it to form an organic phase for use;
[0108] (B) Add 90 g of Tween (80) and 20 g of chitosan to 500 mL of purified water, heat it in a constant temperature water bath at 55 ℃, stir to dissolve it, and form the water phase for use;
[0109] (C) Under the condition of stirring at 800 rpm, slowly add the organic phase to the water phase, keep the temperature at 55 ℃, and stir for 30 minutes;
[0110] (D) Concentrate under reduced pressure to...
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