Preparation method of bacterial cellulose-based antibacterial dressing

A technology of bacterial cellulose and deionized water, applied in medical science, bandages, etc., can solve problems such as toxic side effects, bioaccumulation, and unsatisfactory use effects, and achieve the effects of pain relief, good biocompatibility, and easy replacement

Inactive Publication Date: 2018-05-25
常州市协旺纺织品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to realize the antibacterial and antibacterial functionalization of bacterial cellulose dressings by generally adopting the method of loading nano-silver in the existing dressings, and long-term and large-scale use will cause bioaccumulation and toxic and side effects, and the use effect is not ideal. Problem, a preparation method of bacterial cellulose antibacterial dressing is provided

Method used

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  • Preparation method of bacterial cellulose-based antibacterial dressing

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example 1

[0022] Take 20g of glucose, 5g of yeast extract, 15g of agar, and 5g of peptone, add them to 800mL of deionized water, stir at 300r / min for 20min, and adjust the pH to 5.0 with citric acid, then place them in an autoclave at 121°C, Sterilize for 20 minutes to obtain the fermentation medium, inoculate Acetobacter xylinum into 100 mL of fermentation medium according to the inoculum amount of 5% (V / V), cultivate it in a constant temperature incubator at 30°C for 7 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 100mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 70°C for 1 hour and then replace the hydrogen Repeat the soaking operation in sodium oxide solution for 3 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. T...

example 2

[0024]Take 22g of glucose, 6g of yeast extract, 17g of agar, and 7g of peptone, add it to 900mL of deionized water, stir at 350r / min for 25min, and adjust the pH to 5.5 with citric acid, then place it in an autoclave at 123°C, Sterilize for 25 minutes to obtain the fermentation medium. Inoculate Acetobacter xylinum into 110 mL of fermentation medium according to the inoculum volume of 6% (V / V), culture it in a constant temperature incubator at 31°C for 8 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 150 mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 75°C, soak for 1 hour, and then replace the hydrogen Repeat the soaking operation in sodium oxide solution 4 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. Take...

example 3

[0026] Take 25g of glucose, 8g of yeast extract, 20g of agar, and 8g of peptone, add them to 1000mL of deionized water, stir at 400r / min for 30min, and adjust the pH to 6.0 with citric acid, then put it in an autoclave, at 125°C, Sterilize for 30 minutes to obtain the fermentation medium, inoculate Acetobacter xylinum into 120 mL of fermentation medium according to the inoculum amount of 8% (V / V), culture it in a constant temperature incubator at 32°C for 10 days, and take out the surface of the fermentation medium with tweezers The resulting gel-like product was obtained as a bacterial cellulose hydrogel membrane. Soak the bacterial cellulose hydrogel membrane in 200mL of 0.1% sodium hydroxide solution in a constant temperature water bath at 80°C for 2 hours and replace the hydrogen Repeat the soaking operation in sodium oxide solution 5 times, then soak and wash with deionized water until the washing liquid is neutral, and obtain purified bacterial cellulose gel. Take 0.02g o...

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Abstract

The invention relates to a preparation method of a bacterial cellulose-based antibacterial dressing, and belongs to the technical field of medicinal materials. Silver nitrate, zinc nitrate, a trisodium citrate solution and the like are mixed into a silver and zinc antibacterial agent; then, the silver and zinc antibacterial agent is adhered to the surface of bacterial cellulose through a dopaminepolymerization reaction; through the silver and zinc ion reducing and chelating effects of the bacterial cellulose and polydopamine, spherical or subspheroidal nanosilver and nanozinc are produced byan in-situ silver and zinc ion reducing method; the nanosilver and the nanozinc are face-centered cubic crystal forms and are uniformly distributed in a three-dimensional network structure of the bacterial cellulose to prepare the bacterial cellulose-based antibacterial dressing which has good water absorbability and biocompatibility, can play roles in absorbing an exudate at a wound, keeping thewound moist, cleaning the wound and accelerating wound healing, can be closely adhered to the uneven wound without conglutination and is easy to replace.

Description

technical field [0001] The invention relates to a preparation method of bacterial cellulose antibacterial dressing, which belongs to the technical field of medicinal materials. Background technique [0002] Skin is an important part of the human body, which can protect the internal environment of the body and maintain its stability. When the skin is damaged, the functional form of the limbs will be seriously affected. People are constantly looking for effective ways to treat skin wounds, and applying dressings is one of the most basic and important methods. Dressings can not only cover and bandage the wound, protect the wound, but also prevent the evaporation and loss of water and body fluids from the wound, prevent pollution, and promote wound healing. Finding dressing materials with superior performance is the basis for preparing wound dressings. Bacterial cellulose has good bioaffinity, biocompatibility, biodegradability, biocompatibility and no allergic reaction, as w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0019A61L26/0023A61L26/0066A61L26/008A61L26/009A61L2300/102A61L2300/104A61L2300/21C08L1/02C08L79/02
Inventor 皮蒙王文新史玉兰
Owner 常州市协旺纺织品有限公司
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