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Application of mangiferin and analogue thereof in preparing weight-reducing medicine or food

A technology of mangiferin and analogs, applied in the field of new drug use, can solve the problems of unreported effects, unclear mechanism of action, etc., and achieve the effects of low dosage, significant curative effect, and convenience for patients.

Inactive Publication Date: 2018-06-01
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although mangiferin has such a variety of biological activities, its role in biological weight loss has not been reported. The present invention finds that the compound loses weight through preliminary activity screening, but the mechanism of action is still unclear

Method used

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  • Application of mangiferin and analogue thereof in preparing weight-reducing medicine or food
  • Application of mangiferin and analogue thereof in preparing weight-reducing medicine or food
  • Application of mangiferin and analogue thereof in preparing weight-reducing medicine or food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of mango leaf extract preparation: 40 kilograms of mango leaves are harvested and dried, beaten into coarse powder, 60% ethanol aqueous solution, soaked for 6 hours, and the ratio of solid to liquid is 1:20, and then use macroporous resin for the previous stage The crude extract of mango flavonoids was initially separated and purified, followed by dynamic adsorption and elution; after dissolving the extract obtained in the previous step with pH=8 sodium bicarbonate solution, a certain amount of 75% acetic acid was added to precipitate to obtain 100 g of crude mango extract.

[0036] Purification of mangiferin: first, 80 g of the mangiferin extract (crude product) obtained above is heated and dissolved with methanol at 40° C., concentrated to 15% of the initial volume after complete dissolution, and crystallized by cooling at 4° C.; Glycoside repeated the above steps to crystallize again, and finally obtained 95% mangiferin 15g.

[0037] Mangiferin analog preparat...

Embodiment 2

[0047] Pharmacodynamics experiment of mangiferin for weight loss:

[0048] Experimental Materials:

[0049] Animals: 96 C57BL / 6J mice, male.

[0050] Test drug: mangiferin Positive control drug: Orlistat

[0051] Kits: mouse leptin kit (Lianke Biological Co., Ltd., Hangzhou, China); mouse fatty acid synthase and mouse fatty acid synthase kit (Shanghai Enzyme Biotechnology Co., Ltd., Shanghai, China); container Preparation Weigh 25g of CMC-Na, add 5000ml of distilled water and heat in an electric furnace to dissolve, then cool.

[0052] Grouping and administration are as follows:

[0053] Principles of gavage: Each mouse is gavaged with a solution volume not exceeding 0.6 mL, once a day.

[0054] Grouping and dosage are as follows

[0055] Prevention group:

[0056] (1) Normal group 1: normal diet, and at the same time, 0.5% CMC-Na solution was intragastrically administered once a day until the end of the experiment.

[0057] (2) High-dose mangiferin group (200 mg / kg / D):...

Embodiment 3

[0096] According to the method of Example 1, mangiferin, mangiferin extract, and mangiferin analogues were first prepared, and water for injection was added as usual, finely filtered, potted and sterilized to make an injection.

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Abstract

The invention relates to application of mangiferin and an analogue thereof or a mango leaf extract in preparing a weight-reducing medicine or food. The application is characterized in that the total content of the mangiferin and the analogue thereof in the mango leaf extract is 60 to 90 percent; the mangiferin analogue is a monomeric compound, or a mixture of any multiple compounds; a medicine composition contains the mangiferin and the analogue thereof or the mangiferin extract with the treatment effective dosage, and a medicinal carrier. An action mechanism is characterized by achieving a weigh-reducing effect through inhibiting expression of Leptin in a mice serum and further influencing mice appetite and reducing TC and LDL-C in the serum.

Description

Technical field: [0001] The invention belongs to the field of medicine and food. Specifically, the present invention relates to a new application of medicine, using the compound mangiferin or the plant extract rich in mangiferin or the modification of mangiferin for weight loss treatment or prevention. Background technique: [0002] With the development of modern society and the improvement of people's living standards, cardiovascular and cerebrovascular diseases are common diseases of the elderly, which not only have a high disability rate, but also threaten the lives of patients if they are not treated in time. According to statistics, the number of deaths due to cardiovascular and cerebrovascular diseases in the world is as high as 15 million every year, and the fatality rate ranks first among various diseases. Obesity is an important cause of diabetes and cardiovascular and cerebrovascular diseases. One of the hot spots of attention. [0003] As for the causes of obesi...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/7048A61K36/22A61P3/04A23L33/105
CPCA23L33/105A23V2002/00A61K31/352A61K31/7048A61K36/22A23V2200/332A23V2250/2116
Inventor 胡江苗杨柳周俊颜莎李金玉邝梦婷杨晓蓓
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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