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A kind of Yangxue Anshen enteric-coated tablet and preparation method thereof

A technology for nourishing blood and calming the nerves, enteric-coated tablets, applied in the directions of blood diseases, pharmaceutical formulations, nervous system diseases, etc., can solve the problems of poor stability, low catalpol content, unstable chemical properties of catalpol, etc., and achieves high stability, high Controllable quality and retention of active ingredients

Active Publication Date: 2021-02-19
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical properties of catalpol are unstable, and the content in Rehmannia glutinosa is affected by various factors. The content of catalpol in the existing nourishing blood and tranquilizing preparations is relatively low, and the stability is poor

Method used

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  • A kind of Yangxue Anshen enteric-coated tablet and preparation method thereof
  • A kind of Yangxue Anshen enteric-coated tablet and preparation method thereof
  • A kind of Yangxue Anshen enteric-coated tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] prescription:

[0040]

[0041] (1) Crush one-third of Shouwu vine into fine powder, and pass through a 100-mesh sieve; talc powder, pass through a 120-mesh sieve.

[0042] (2) Ultrasonic extraction of the remaining Shouwu vine, rehmannia glutinosa and rehmannia root was carried out twice with ethanol aqueous solution, each time for 2 hours, adding 8 times the amount of 70% ethanol aqueous solution for the first time, and adding 6 times the amount of 60% ethanol for the second time. % ethanol aqueous solution, combine the extracts, control the vacuum to be 0.08Mpa, and concentrate the extracts to a clear paste with a relative density of 1.15 (50°C).

[0043] (3) Add water to decoct the remaining four flavors of the original medicinal materials twice, each time for 3 hours, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, combine the decoction, filter, and concentrate the filtrate into Thick paste, controlled v...

Embodiment 2

[0047] prescription:

[0048]

[0049] (1) Crush one-third of Shouwu vine into fine powder, and pass through a 100-mesh sieve; talc powder, pass through a 120-mesh sieve.

[0050](2) Ultrasonic extraction of the remaining Shouwu vine, rehmannia glutinosa and rehmannia root was carried out twice with ethanol aqueous solution, each time for 1.5 hours, adding 8 times the amount of 70% ethanol aqueous solution for the first time, and adding 6 times the amount of 60% ethanol for the second time. % ethanol aqueous solution, combine the extracts, control the vacuum to be 0.06Mpa, and concentrate the extracts to a clear paste with a relative density of 1.20 (50°C).

[0051] (3) Add water to decoct the remaining four flavors of the original medicinal materials twice, each time for 3 hours, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, combine the decoction, filter, and concentrate the filtrate into Thick paste, controlled ...

Embodiment 3

[0055] prescription:

[0056]

[0057]

[0058] (1) Crush one-third of Shouwu vine into fine powder, and pass through a 100-mesh sieve; talc powder, pass through a 120-mesh sieve.

[0059] (2) Ultrasonic extraction of the remaining Shouwu vine, Rehmannia glutinosa and Rehmannia glutinosa was carried out twice with an aqueous ethanol solution, each time for 1 hour, adding 7 times the amount of 70% ethanol aqueous solution for the first time, and adding 7 times the amount of 60% ethanol for the second time. % ethanol aqueous solution, combine the extracts, control the vacuum to be 0.04Mpa, and concentrate the extracts to a clear paste with a relative density of 1.20 (50°C).

[0060] (3) Add water to decoct the remaining four flavors of the original medicinal materials twice, each time for 3 hours, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time, combine the decoction, filter, and concentrate the filtrate into Thick ...

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Abstract

The invention discloses an enteric-coated tablet for nourishing blood and tranquilizing the nerves, which is characterized in that it comprises the following medicinal materials and auxiliary materials in parts by weight: 80-130 parts of agrimony, 50-80 parts of Eclipta, 50-80 parts of Gallispaulis, Rehmannia glutinosa 50-80 parts of yellow, 50-80 parts of rehmannia, 50-80 parts of acacia bark, 50-80 parts of Shouwu vine, 10-20 parts of magnesium stearate, 8-13 parts of acrylic resin No. II, diphthalic acid 1-5 parts of ethyl ester, 1-5 parts of Tween-80, 1-5 parts of talcum powder, 1-5 parts of lemon yellow, 1-5 parts of Sichuan wax. During the preparation process, the remaining shouwu vine, rehmannia glutinosa and rehmannia glutinosa were ultrasonically extracted with ethanol aqueous solution, and the remaining four medicinal materials were decocted with water. High, and its preparation method is simple, without any special equipment, suitable for industrial production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Yangxue Anshen enteric-coated tablet and a preparation method thereof. Background technique [0002] At present, due to increasingly fierce social competition, accelerated pace of life, population aging and changes in disease spectrum, the incidence of insomnia has risen sharply. Long-term use of sleeping pills is prone to drug dependence, and can also cause iatrogenic diseases, but traditional Chinese medicine can significantly improve sleep conditions by adjusting the balance of qi and blood in the human body, without causing drug dependence, and will not cause iatrogenic diseases , has certain advantages. [0003] The Chinese patent application with the publication number CN1456248A discloses a preparation method of Yangxue Anshen Capsules. In the preparation method, 1 / 3 of the Shouwu vine is crushed into fine powder, and the remaining Shouwu vine is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/32A61K36/804A61P25/20A61P7/00
CPCA61K9/2013A61K9/2846A61K36/28A61K36/48A61K36/486A61K36/704A61K36/73A61K36/804A61K2300/00
Inventor 刘景萍刘全国陈克领王家李党
Owner HAINAN HULUWA PHARMA GRP CO LTD