A kind of polymer copolymer material with hemostatic effect and preparation method thereof

A technology of high molecular copolymer and hemostatic effect, which can be used in drug delivery, pharmaceutical formulations, bandages, etc. It can solve the problems of unstable hemostatic effect, difficulty in controlling the amount of powder, and washing away, so as to achieve good hemostatic effect, low cost, and human body safe effect

Active Publication Date: 2020-05-22
NANTONG HOLYCON MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also some new hemostatic materials that use water-absorbing resin or hydrogel to absorb a large amount of water in the blood in a short period of time to promote the activation of the coagulation mechanism and stop bleeding. However, the above-mentioned materials are generally powder materials in the preparation process.
In actual use, the amount of powder is difficult to control, and it is easy to wash away with the flow of blood, resulting in unstable hemostatic effect

Method used

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  • A kind of polymer copolymer material with hemostatic effect and preparation method thereof
  • A kind of polymer copolymer material with hemostatic effect and preparation method thereof
  • A kind of polymer copolymer material with hemostatic effect and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] (1) Taking carboxymethyl cellulose gauze as raw material, putting it into a NaOH solution with a mass fraction of 20% to carry out dipping and alkalization, the dipping time is 32min, and the alkalization temperature is 15°C to become alkalized cellulose;

[0038] (2) Centrifuge the alkalized cellulose, the mass ratio of the alkalized cellulose before and after pressing is 3.5:1, put it into the ethanol solution of chloroacetic acid with a concentration of 0.5mol / L, heat, the temperature is 65°C, and carry out ether Etherification reaction, etherification time 30min, obtain etherification product, etherification product is the carboxymethyl cellulose gauze of different degree of substitution, the carboxyl mass fraction of described carboxymethyl cellulose gauze is 10%;

[0039] (3) Centrifuge the etherification product, wash it with ethanol solution, then remove ethanol by centrifugation, dry it in a vacuum drying oven less than 50°C, and cut it;

[0040] (4) Arrange th...

Embodiment 2

[0043] (1) Use clean regenerated cellulose gauze as the raw material, place it in a temperature-controllable flat alkalization tank, spread it on the bottom of the alkalization tank, and put it into the NaOH solution with a mass fraction of 25% for dipping and alkalization , to become alkalized cellulose, wherein the mass volume ratio of regenerated cellulose gauze to NaOH solution is 1g:12ml, and the soaking time is 25min. During dipping, a roller is used to repeatedly squeeze the gauze to ensure sufficient dipping and alkali solution absorption, alkalized The temperature is controlled at 10°C;

[0044] (2) Take out the alkalized cellulose from the alkalization tank, place it in a low-speed centrifuge for centrifugal pressing, remove excess lye, the mass ratio of alkalized cellulose before and after centrifugal pressing is 3:1, and chloroacetic ethanol The solution is placed in an etherification reaction tank, wherein the mass ratio of chloroacetic acid to regenerated fiber is ...

Embodiment 3

[0049] (1) Use clean regenerated cellulose gauze as raw material, place it in a temperature-controllable flat alkalization tank, spread it on the bottom of the alkalization tank, and put it into the NaOH solution with a mass fraction of 20% for dipping and alkalization , to become alkalized cellulose, wherein the mass volume ratio of carboxymethyl cellulose gauze to NaOH solution is 1g:16ml, and the soaking time is 30min. During dipping, a roller is used to repeatedly squeeze the gauze to ensure sufficient soaking and the absorption of alkali solution. The melting temperature is controlled at 20°C;

[0050] (2) Take out the alkalized cellulose from the alkalization tank, place it in a low-speed centrifuge for centrifugal pressing, remove excess lye, the mass ratio of alkalized cellulose before and after centrifugal pressing is 4:1, and chloroacetic ethanol The solution is placed in an etherification reaction tank, wherein the mass ratio of chloroacetic acid to alkalized cellul...

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Abstract

The invention discloses a high-molecular copolymer material with hemostatic effect and a preparation method thereof. The high-molecular copolymer material has a network structure, and its molecular formula is shown in formula (I). The high-molecular copolymer material with hemostatic effect of the present invention is The molecular copolymer material is a strong fabric-like material, which can have a good hemostatic effect on moderate to severe traumatic bleeding. The hemostatic effect is stable, high-speed, fast, easy to use, and low in cost. It has no side effects and is safe for the human body. Moreover, the preparation method of the invention is simple and easy to produce.

Description

technical field [0001] The invention belongs to the technical field of new materials for medical devices, and in particular relates to a polymer copolymer material with hemostatic effect and a preparation method thereof. Background technique [0002] Hemorrhage refers to the massive and sudden bleeding caused by the rupture of larger arteries or veins in animals or humans caused by trauma. Hemostasis emergency treatment of hemorrhage caused by moderate and severe trauma has always been a difficult problem in the medical field. The main cause of traumatic death, especially in the field of pre-hospital first aid such as wars, natural disasters, traffic accidents, and emergencies, rapid hemostasis is an important link. Generally speaking, bleeding from small wounds can be suppressed by the coagulation function of the blood itself and some additional nursing measures, but for moderate to severe traumatic bleeding, especially massive bleeding caused by venous artery trauma, when ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/02C08B1/08C08B11/12C08B3/08A61L15/24
CPCA61L15/24A61L2400/04C08B1/08C08B3/08C08B11/12C08F251/02C08L51/02C08F220/06
Inventor 陈磊
Owner NANTONG HOLYCON MEDICAL DEVICES
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