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Method for preparing personalized degradable metal stent or internal fixation device based on 3D printing

A metal bracket and 3D printing technology, applied in brackets, additive processing and other directions, can solve the problems of aluminum toxicity and sensitization, zinc alloy inability, poor mechanical properties of pure zinc, etc., to improve processing efficiency, reduce production costs, The effect of avoiding machining defects

Inactive Publication Date: 2018-06-05
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the mechanical properties of pure zinc are poor. The tensile strength of as-cast pure zinc is only 20MPa, and the elongation at break is 0.2%. It needs alloying and processing methods to improve its mechanical properties.
[0009] At present, the existing grades of zinc alloys all contain aluminum, and aluminum is toxic and sensitizing in the human body, so the existing zinc alloys cannot be used as materials for degradable metal stents

Method used

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  • Method for preparing personalized degradable metal stent or internal fixation device based on 3D printing
  • Method for preparing personalized degradable metal stent or internal fixation device based on 3D printing
  • Method for preparing personalized degradable metal stent or internal fixation device based on 3D printing

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Embodiment 1: Zn-1Mg alloy "S" shape bracket

[0064] (1) Structural analysis and modeling of degradable metal stents

[0065] ①The casting material is zinc alloy (Zn-1Mg alloy), which is made by melting pure zinc (99.99+%) and pure magnesium (99.99+%). The melting point is around 420°C. Based on the designed support structure and the technical requirements for low-melting thin-wall parts casting, it is determined that the casting process used is lost-wax casting;

[0066] ②According to coronary angiography, measure the diameter of the lesion vessel by QCA (qualitative comparative analysis) technology, obtain the shape data of the lesion vessel, and design the personalized degradable stent. The diameter of the diseased blood vessel was measured to be 10mm, figure 1 The "S"-shaped scaffold structure suitable for the patient's lesion determined by three-dimensional reconstruction is given;

[0067] ③Establish the 3D model of the wax model of the intravascular stent in ...

Embodiment 2

[0080] Embodiment 2: Zn-1Li alloy rhombic grid support

[0081] (1) Structural analysis and modeling of degradable metal stents

[0082] ①The casting material is zinc alloy (Zn-1Li alloy), which is made of pure zinc (99.99+%) and pure lithium (99.99+%) through vacuum melting. The melting point is around 420°C. According to the designed support structure and the technical requirements for low-melting thin-wall casting, it is determined that the casting process used is lost-wax casting;

[0083] ②According to coronary angiography, QCA technology is used to obtain the morphological data of diseased blood vessels, and the design of personalized degradable stents is carried out. The diameter of the diseased blood vessel was measured to be 10mm, figure 2 A diamond-shaped grid stent structure with slightly larger openings at both ends determined by three-dimensional reconstruction is given;

[0084] ③ Establish a 3D model of the wax model of the intravascular stent in the compute...

Embodiment 3

[0097] Embodiment 3: Zn-4Cu alloy cone structure and special-shaped bifurcation structure support

[0098] (1) Structural analysis and modeling of degradable metal stents

[0099] ①The casting material is zinc alloy (Zn-4Cu alloy), which is made by melting pure zinc (99.99+%) and H62 brass (Cu-38wt%Zn). mm, according to the designed support structure and the technical requirements for low-melting thin-wall parts casting, it is determined that the casting process used is lost-wax casting;

[0100] ②According to coronary angiography, QCA technology is used to obtain the morphological data of diseased blood vessels, and the design of personalized degradable stents is carried out. The measured shape of the two diseased coronary vessels is not the traditional single cylindrical shape, one is a conical structure, the diameter of the large end is 3cm, the diameter of the small end is 2cm, and the length of the stent is 5cm; the other is abnormal Bifurcation structure, the shape of ...

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Abstract

The invention discloses a method for preparing a personalized degradable metal stent or an internal fixation device based on 3D printing. The method comprises the following steps: (1) obtaining data of corresponding size parameters of a lesion in a human body through a QCA technology, and obtaining a structure of a blood vessel stent, other metal stents or the internal fixation device by three-dimensional reconstruction; (2) establishing a 3D model of a wax mold prototype of the blood vessel stent, other metal stents or the internal fixation device, and decomposing the 3D model into a series of 2D sheet models; (3) using a 3D printing technology to make the wax mold prototype; (4) leading gypsum into the wax mold prototype for shaping; after the gypsum is hardened, baking the gypsum to completely vaporize and evaporate the wax mold prototype, and then casting alloy melt; and after the casting is completed, breaking a shell to obtain the metal stent or the internal fixation device. According to the method, personalized customization can be performed according to a patient's diseased blood vessel, and the obtained metal stent or the internal fixation device is degradable, high in precision and good in mechanical properties and corrosion performance.

Description

technical field [0001] The invention belongs to the technical field of implantable medical devices, in particular to a method for preparing personalized degradable metal stents or internal fixation devices based on 3D printing. Background technique [0002] Vascular stents are tubular devices used to support stenotic and occluded blood vessels in the human body, reduce elastic retraction and reshaping of blood vessels, and maintain smooth blood flow in the lumen. . Intravascular stent implantation has become the main method for the treatment of cardiovascular diseases caused by atherosclerosis, which can greatly reduce the mortality rate of myocardial infarction and the risk of severe or fatal cardiac events. Since Sigwait first successfully implemented coronary artery stent surgery in 1987, vascular stents have developed rapidly, from permanent bare metal stents (BMS), drug-eluting stents (DES) to biodegradable stents (Biodegradable stents) , BDS) research and development...

Claims

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Application Information

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IPC IPC(8): A61F2/915B33Y10/00B33Y50/00B33Y40/00B33Y70/00
CPCA61F2/915A61F2002/91533A61F2002/9155B33Y10/00B33Y40/00B33Y50/00B33Y70/00
Inventor 王小健盛银莹李卫
Owner JINAN UNIVERSITY
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