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Preparation method of urease inhibitor

A technology of urease inhibitor and nitrobenzaldehyde, which is applied in fertilizer mixtures, fertilization devices, applications, etc., can solve the problems of large toxic and side effects, easy decomposition of active ingredients, easy dissolution and easy loss, etc., and achieves the effect of inhibiting urease activity

Inactive Publication Date: 2018-06-15
常州市雄图纺织有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention: the purpose of the present invention is to provide a preparation method of urease inhibitors for the current problems of urease inhibitors with large toxic and side effects, easy dissolution and loss, short effective inhibition time, and easy decomposition of active components

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  • Preparation method of urease inhibitor
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preparation example Construction

[0017] A preparation method of urease inhibitor, comprising the steps of:

[0018] (1) Mix nitrobenzaldehyde with malonic acid and absolute ethanol at a mass ratio of 1:1:30, stir and reflux at 80~85°C for 1~2 hours to obtain a nitrobenzaldehyde reaction solution, and pour it into nitrobenzaldehyde Pyridine was added to the base benzaldehyde reaction solution at a mass ratio of 20:3, stirred and refluxed for about 7-8 hours, cooled and filtered with suction to obtain the crude product of p-nitrocinnamic acid, which was washed with distilled water for 3-5 Once, dry to obtain the dried crude product, dissolve the dried crude product in water at a mass ratio of 1:10 to obtain a crude product solution, adjust the pH value of the crude product solution to 7.0±0.2 with NaOH solution, filter to get the filtrate A , add hydrochloric acid to the filtrate A to adjust the pH value to 3.0±0.2, filter, take the filtrate B, add ethanol solution to the filtrate B at a volume ratio of 1:5 for...

Embodiment 1

[0021] A preparation method of urease inhibitor, comprising the steps of:

[0022] (1) Mix nitrobenzaldehyde with malonic acid and absolute ethanol at a mass ratio of 1:1:30, stir and reflux for 1~2 hours at 80°C to obtain a nitrobenzaldehyde reaction liquid, which is injected into nitrobenzene Add pyridine to the formaldehyde reaction solution at a mass ratio of 20:3, stir and reflux for about 7 hours, cool and filter with suction to obtain the crude product of p-nitrocinnamic acid, wash the crude product of p-nitrocinnamic acid three times with distilled water, and dry to obtain Dry the crude product, dissolve the dried crude product in water at a mass ratio of 1:10 to obtain a crude product solution, adjust the pH value of the crude product solution to 7.0±0.2 with NaOH solution, filter the filtrate A, add Adjust the pH value to 3.0±0.2 with hydrochloric acid, filter, take filtrate B, add ethanol solution to filtrate B at a volume ratio of 1:5 for recrystallization, and obt...

Embodiment 2

[0025] A preparation method of urease inhibitor, comprising the steps of:

[0026] (1) Mix nitrobenzaldehyde with malonic acid and absolute ethanol at a mass ratio of 1:1:30, stir and reflux for 1 hour at 83°C to obtain a nitrobenzaldehyde reaction liquid, which is reacted with nitrobenzaldehyde Add pyridine to the liquid at a mass ratio of 20:3, stir and reflux for about 7 hours, cool and filter with suction to obtain the crude product of p-nitrocinnamic acid, wash the crude product of p-nitrocinnamic acid four times with distilled water, and dry to obtain Crude product, the dried crude product was dissolved in water at a mass ratio of 1:10 to obtain a crude product solution, and the pH value of the crude product solution was adjusted to 7.0±0.2 with NaOH solution, and the filtrate A was obtained by filtration, and hydrochloric acid was added to the filtrate A to dissolve Adjust the pH value to 3.0±0.2, filter, take the filtrate B, add ethanol solution to the filtrate B at a ...

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Abstract

The invention relates to the technical field of fertilizers and particularly relates to a preparation method of a urease inhibitor. The preparation method comprises that ketonic oxygen of urea and Ni1undergo a coordination reaction, simultaneously or subsequently, amino nitrogen of the urea and Ni2 undergo a coordination reaction, and the hydroxyl oxygen for bridging two Ni attacks carbonyl carbon of the urea. P-nitrobenzaldehyde as a raw material is synthesized into p-nitrocinnamic acid, and the p-nitrocinnamic acid as a ligand is synthesized into a novel p-nitrocinnamic acid transition metal complex through a solution crystallization method. Copper can inhibit the activation process of a urease apoprotein, irreversibly occupy the binding site of nickel to cause irreversible inhibition of urease activity and produce urease inhibitory activity to nitro-cinnamic acid because when the nitro-cinnamic acid and urease are bonded, the nitro-cinnamic acid may cover the urease active site thereby blocking the path of urea entering the active site so that urease activity is inhibited.

Description

technical field [0001] The invention relates to the technical field of fertilizers, in particular to a preparation method of a urease inhibitor. Background technique [0002] Dry direct seeding of rice is a new type of high-efficiency, labor-saving, water-saving and easy-to-mechanize cultivation technology. It is also one of the preferred technologies for stabilizing the area and increasing the yield during the transition period of the current rice production technology. As a new high-efficiency water-saving cultivation technology, dry direct seeding of rice plays an irreplaceable role in stabilizing the rice planting area, and has broad development prospects in our country. However, in large-scale production, the low seedling rate and irregular seedling emergence are the key restrictive factors for the large-scale promotion of dry direct seeding. The reason is that the high concentration of ammonia volatilization after applying a large amount of urea as base fertilizer is ...

Claims

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Application Information

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IPC IPC(8): C07F1/08C05G3/08C05G3/90
CPCC05G3/90C07F1/08
Inventor 刘蓉蓉李璐尹凯欣
Owner 常州市雄图纺织有限公司